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OBJECTIVE: This study aimed to demonstrate the initial experience of using fast quantitative magnetic resonance imaging (MRI) to evaluate hydrocephalus. METHODS: A total of 109 brain MRI volumetry examinations (acquisition time, 7 minutes 30 seconds) were performed in 72 patients with hydrocephalus. From the measured ventricular system and brain volumes, ventricle-brain volume percentage was calculated to standardize hydrocephalus severity (processing time, <5 minutes). The obtained values were categorized into no, mild, and severe based on the fronto-occipital horn ratio (FOHR) and the ventricle-brain volume percentages reported in the literature. The measured volumes and percentages were compared between patients with mild hydrocephalus and those with severe hydrocephalus. The diagnostic performance of brain hydrocephalus MRI volumetry was evaluated using receiver operating characteristic curve analysis. RESULTS: Ventricular volumes and ventricle-brain volume percentages were significantly higher in in patients with severe hydrocephalus than in those with mild hydrocephalus (FOHR-based severity: 352.6 ± 165.6 cm 3 vs 149.1 ± 78.5 cm 3 , P < 0.001, and 26.8% [20.8%-33.1%] vs 12.1% ± 6.0%, P < 0.001; percentage-based severity: 359.5 ± 143.3 cm 3 vs 137.0 ± 62.9 cm 3 , P < 0.001, and 26.8% [21.8%-33.1%] vs 11.3% ± 4.2%, P < 0.001, respectively), whereas brain volumes were significantly lower in patients with severe hydrocephalus than in those with mild hydrocephalus (FOHR-based severity: 878.1 ± 363.5 cm 3 vs 1130.1 cm 3 [912.1-1244.2 cm 3 ], P = 0.006; percentage-based severity: 896.2 ± 324.6 cm 3 vs 1142.3 cm 3 [944.2-1246.6 cm 3 ], P = 0.005, respectively). The ventricle-brain volume percentage was a good diagnostic parameter for evaluating the degree of hydrocephalus (area under the curve, 0.855; 95% confidence interval, 0.719-0.990; P < 0.001). CONCLUSIONS: Brain MRI volumetry can be used to evaluate hydrocephalus severity and may provide guide interpretation because of its rapid acquisition and postprocessing times.
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Hidrocefalia , Humanos , Hidrocefalia/diagnóstico por imagen , Encéfalo/diagnóstico por imagen , Encéfalo/patología , Ventrículos Cerebrales/diagnóstico por imagen , Imagen por Resonancia Magnética/métodos , Estudios RetrospectivosRESUMEN
High-resolution, isotropic, 3-dimensional (D) data from pediatric cardiovascular computed tomography (CT) offer great potential for the accurate quantitative evaluation of pediatric cardiovascular and pulmonary vascular diseases. Recent pilot studies using pediatric 3-D cardiovascular CT have shown promising results in assessing cardiac function in conditions such as tetralogy of Fallot, cardiac defects with a hypoplastic ventricle, Ebstein anomaly, and in quantifying myocardial mass. In addition, the quantitative assessment of pulmonary vascularity is useful for evaluating differential right-to-left pulmonary vascular volume ratio, the effectiveness of pulmonary angioplasty, and predicting pulmonary hypertension. These initial experiences could broaden the role of pediatric cardiovascular CT in clinical practice. Furthermore, the current barriers to its widespread use, pertinent solutions to these problems, and new applications are discussed. In this review, the 3-D quantitative evaluations of cardiac function and pulmonary vascularity using high-resolution pediatric cardiovascular CT data are illustrated.
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Tetralogy of Fallot is the most prevalent cyanotic congenital heart disease, requiring lifelong multimodality non-invasive cardiac imaging, such as echocardiography, cardiothoracic computed tomography, and cardiac magnetic resonance imaging. As imaging techniques continuously evolve and are gradually integrated into clinical practice, there is a critical need to update multimodality imaging protocols. Over the last two decades, cardiothoracic computed tomography imaging techniques have advanced remarkably, significantly enhancing its role in evaluating patients with tetralogy of Fallot. In this review, we describe contemporary multimodality non-invasive cardiac imaging protocols for tetralogy of Fallot, emphasizing the expanding role of cardiothoracic computed tomography. Additionally, we present standardized reporting forms designed to facilitate the clinical adoption of these protocols.
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Imagen Multimodal , Tetralogía de Fallot , Tetralogía de Fallot/diagnóstico por imagen , Humanos , Imagen Multimodal/métodos , Tomografía Computarizada por Rayos X/métodos , Ecocardiografía/métodos , Imagen por Resonancia Magnética/métodos , Niño , Protocolos ClínicosRESUMEN
Detailed three-dimensional cardiac segmentations using cardiac computed tomography (CT) data is technically feasible in patients with Ebstein anomaly, but its complementary role has not been evaluated. This single-center, retrospective study was aimed to evaluate the complementary role of cardiac CT ventricular volumetry in evaluating the severity of Ebstein anomaly. Preoperative cardiac CT ventricular volumetry was performed in 21 children with Ebstein anomaly. CT-based ventricular functional measures were compared between Carpentier types, and between definitive surgical repair types. The Celermajer severity index measured with echocardiography was correlated with CT-based functional parameters. Total right ventricle (RV) and functional RV (fRV) volumes, fRV fraction, fRV/left ventricle (LV) volume ratio, and end-diastolic CT severity index demonstrated statistically significant differences between Carpentier type A/B and Carpentier type C/D (p < 0.05). The Celermajer severity index measured with echocardiography showed a high positive correlation with the end-diastolic CT severity index (R = 0.720, p < 0.002). There were no statistically significant differences in both echocardiography- and CT-based functional measures between patients with biventricular repair and patients with one-and-a-half or univentricular repair (p > 0.05). Compared with echocardiography, cardiac CT ventricular volumetry can provide the severity of Ebstein anomaly objectively and may be used in select patients when echocardiographic results are inconclusive or inconsistent.
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Anomalía de Ebstein , Niño , Humanos , Anomalía de Ebstein/diagnóstico por imagen , Anomalía de Ebstein/cirugía , Ventrículos Cardíacos/diagnóstico por imagen , Estudios Retrospectivos , Ecocardiografía/métodos , Imagen por Resonancia Cinemagnética/métodosRESUMEN
The role of preoperative cardiac computed tomography (CT) in neonates with pulmonary atresia and intact ventricular septum (PA-IVS) remains unclear. This study was aimed to elaborate the role of preoperative CT-derived anatomical and functional findings in planning treatment strategies in neonates with PA-IVS. The presence of ventriculocoronary arterial connections was evaluated by CT. CT-derived ventricular volumetric parameters were compared and correlated with echocardiographic tricuspid valve (TV) z-score in 12 neonates with PA-IVS. Cardiac CT and echocardiographic findings were compared between definite surgical types (median follow-up, 4 years). Ventriculocoronary arterial connections were identified with CT in 58.3% of cases (7/12) and associated with higher incidence of Fontan procedure (42.9%, 3/7) and high mortality (28.6%, 2/7). The CT-derived and echocardiographic TV z-scores exhibited a high correlation (R = 0.924, p < 0.001). The CT-derived right ventricle (RV) volume and RV-left ventricle volume ratio also displayed high correlations (R = 0.875 and 0.867, respectively; p < 0.001) with echocardiographic TV z-score. More positive echocardiographic TV z-score, high CT-derived RV end-diastolic volume and RV-left ventricle volume ratio, and low CT-derived left ventricular end-diastolic volume were observed in biventricular surgery group (N = 2), compared to Fontan operation (N = 3) and 1.5 ventricular surgery (N = 3) groups, and mortality cases (N = 3). Preoperative CT-derived coronary artery anatomy and ventricular volumetric parameters may supplement treatment planning in neonates with PA-IVS especially when multifactorial decision including echocardiographic TV z-score is in a gray zone.W.
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BACKGROUND: Varying degrees of partial volume error depending on the complexity of the endocardial borders are inevitable in threshold-based cardiac computed tomography (CT) ventricular volumetry. These errors can potentially be reduced by using a partial voxel interpolation (PVI) method, but this has not been tested for cardiac CT ventricular volumetry. OBJECTIVE: To evaluate the partial volume error-reducing effects of the PVI method in cardiac CT ventricular volumetry among patients with congenital heart disease (CHD). MATERIALS AND METHODS: The cardiac CT ventricular volumetry data were obtained from 55 patients (median age 12.0 years) with CHD. The ventricular and myocardial volumes, ejection fraction and ventricular mass-volume ratio were quantified and compared before and after the PVI method. The correlation between the myocardial volumes in the end-systolic and end-diastolic phases was tested. The effect of the PVI method on the classification of ventricular hypertrophy was evaluated. RESULTS: The indexed ventricular volumes after PVI were significantly smaller (7.4-11.5%) than those before PVI (P<0.001). In contrast, the indexed myocardial volumes were significantly larger (6.2-27.7%) after PVI (P<0.001). The ejection fractions and mass-volume ratios were significantly larger (1.6-2.2% and 19.7-42.5%, respectively) after PVI (P<0.001 and P<0.001, respectively). The indexed myocardial masses showed prominently high correlation between the end-systolic and end-diastolic phases (R, 0.961-0.990; P<0.001). The proportions of no and severe hypertrophy were significantly decreased (P<0.002) and increased (P<0.032), respectively, after the application of the PVI method. CONCLUSION: The PVI method can reduce partial volume error in cardiac CT ventricular volumetry among patients with CHD.
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Cardiopatías Congénitas , Humanos , Niño , Volumen Sistólico , Cardiopatías Congénitas/diagnóstico por imagen , Ventrículos Cardíacos/anomalías , Tomografía Computarizada por Rayos X/métodos , HipertrofiaRESUMEN
Anomalous pulmonary venous connections represent a heterogeneous group of congenital heart diseases in which a part or all pulmonary venous flow drains directly or indirectly into the right atrium. Clinically, anomalous pulmonary venous connections may be silent or have variable consequences, including neonatal cyanosis, volume overload and pulmonary arterial hypertension due to the left-to-right shunt. Anomalous pulmonary venous connections are frequently associated with other congenital cardiac defects and their accurate diagnosis is crucial for treatment planning. Therefore, multimodality diagnostic imaging, comprising a combination (but not all) of echocardiography, cardiac catheterization, cardiothoracic computed tomography and cardiac magnetic resonance imaging, helps identify potential blind spots relevant to each imaging modality before treatment and achieve optimal management and monitoring. For the same reasons, diagnostic imaging evaluation using a multimodality fashion should be used after treatment. Finally, those interpreting the images should be familiar with the various surgical approaches used to repair anomalous pulmonary venous connections and the common postoperative complications.
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Cardiopatías Congénitas , Venas Pulmonares , Síndrome de Cimitarra , Recién Nacido , Humanos , Síndrome de Cimitarra/cirugía , Cardiopatías Congénitas/diagnóstico por imagen , Corazón , Venas Pulmonares/diagnóstico por imagen , Venas Pulmonares/anomalías , Tomografía Computarizada por Rayos XRESUMEN
Absent pulmonary valve syndrome is a rare congenital heart disease characterized by partial or complete absence of pulmonary valve cusps which commonly presents with respiratory difficulty during infancy. Because central airway compression by dilated central pulmonary arteries is a key pathology of this syndrome responsible for clinical presentation, severity, and outcome, cardiothoracic computed tomography (CT) is currently regarded as the imaging modality of choice before and after treatment. In addition, tracheobronchomalacia frequently responsible for persistent respiratory problems can be accurately evaluated with conventional two-dimensional cine CT or four-dimensional CT. In this pictorial review, various diagnostic imaging methods used to evaluate absent pulmonary valve syndrome are comprehensively illustrated with an emphasis on a recently spotlighted role of cardiothoracic CT.
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Cardiopatías Congénitas , Válvula Pulmonar , Traqueobroncomalacia , Dilatación Patológica , Humanos , Válvula Pulmonar/anomalías , Válvula Pulmonar/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodosRESUMEN
Optimal enhancement of the Fontan pathway is crucial for the accurate CT evaluation. Current guidelines for contrast-enhanced CT protocols are rather inconsistent in scan delays and injection methods. This single-center, retrospective study was performed to compare objective measures of contrast enhancement between 1- and 3-min scan delays (41 and 36 patients, respectively) to determine a better contrast-enhanced CT protocols for evaluating the Fontan pathway. In both groups, a biphasic injection protocol, in which 50% diluted contrast agent (the amount of iodinated contrast agent: 2.0 mL/kg; the amount of saline: 2.0 mL/kg) was injected at the injection rate of 0.5â2.5 mL/s for 50 s followed by a saline flush at the same injection rate (0.5â2.5 mL/s), was used. The degree and heterogeneity of cardiovascular enhancement, image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were quantitatively evaluated. The mean densities of all cardiovascular structures were significantly higher in the 1-min delay protocol than in the 3-min delay protocols (p < 0.001). Heterogeneous enhancement (normalized standard deviation > 0.70) in the Fontan pathway was significantly more frequent in the 1-min delay protocol (p < 0.001). No significant differences were found in image noise (p > 0.141) and the frequency showing suboptimal noise (p = 1.000) between the two protocols. SNR and CNR were significantly lower in the 3-min delay protocol (p < 0.001). Compared with the 1-min delay protocol, the 3-min delay protocol achieved more homogeneous enhancement in the Fontan pathway on CT but showed lower contrast enhancement, SNR, and, CNR, indicating the need for further improvement.
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Sistema Cardiovascular , Medios de Contraste , Humanos , Dosis de Radiación , Estudios Retrospectivos , Relación Señal-Ruido , Tomografía Computarizada por Rayos X/métodosRESUMEN
BACKGROUND: To evaluate the long-term functional and structural pulmonary development in children with repaired congenital diaphragmatic hernia (CDH) and to identify the associated perinatal-neonatal risk factors. METHODS: Children with repaired CDH through corrective surgery who were born at gestational age ≥ 35 weeks were included in this analysis. Those who were followed for at least 5 years were subjected to spirometry and chest computed tomography for evaluation of their functional and structural growth. Main bronchus diameters and lung volumes (total, left/right) were measured. According to total lung volume (TLV) relative to body surface area, children were grouped into TLV ≥ 50 group and TLV < 50 group and the associations with perinatal-neonatal factors were analyzed. RESULTS: Of the 28 children (mean age, 6.2 ± 0.2 years) with left-sided CDH, 7 (25%) had abnormal pulmonary function, of whom 6 (87%) showed restrictive patterns. All pulmonary functions except FEF25-75% were worse than those in matched healthy control group. Worse pulmonary function was significantly associated with small head and abdominal circumferences at birth. The mean TLV was 1339.1 ± 363.9 mL and LLV/TLV was 47.9 ± 2.5 mL. Children with abnormal pulmonary function were more likely to have smaller lung volumes. In multivariate analysis, abdominal circumference at birth was significantly associated with abnormal lung volume. CONCLUSIONS: A quarter of children with repaired CDH showed abnormal pulmonary function. Small abdominal circumference at birth was associated with abnormal pulmonary function and lower TLV. .
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Hernias Diafragmáticas Congénitas , Niño , Femenino , Edad Gestacional , Hernias Diafragmáticas Congénitas/diagnóstico por imagen , Hernias Diafragmáticas Congénitas/cirugía , Humanos , Lactante , Recién Nacido , Pulmón/diagnóstico por imagen , Mediciones del Volumen Pulmonar , EmbarazoRESUMEN
BACKGROUND: A hyperinflammatory immune-mediated shock syndrome has been recognised in children exposed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). OBJECTIVE: To describe typical imaging findings in children with multisystem inflammatory syndrome associated with COVID-19. MATERIALS AND METHODS: During the first wave of the COVID-19 pandemic, imaging studies and clinical data from children treated for multisystem inflammatory syndrome were collected from multiple centres. Standardised case templates including demographic, biochemical and imaging information were completed by participating centres and reviewed by paediatric radiologists and paediatricians. RESULTS: We included 37 children (21 boys; median age 8.0 years). Polymerase chain reaction (PCR) testing was positive for SARS-CoV-2 in 15/37 (41%) children and immunoglobulins in 13/19 children (68%). Common clinical presentations were fever (100%), abdominal pain (68%), rash (54%), conjunctivitis (38%) and cough (32%). Thirty-three children (89%) showed laboratory or imaging findings of cardiac involvement. Thirty of the 37 children (81%) required admission to the intensive care unit, with good recovery in all cases. Chest radiographs demonstrated cardiomegaly in 54% and signs of pulmonary venous hypertension/congestion in 73%. The most common chest CT abnormalities were ground-glass and interstitial opacities (83%), airspace consolidation (58%), pleural effusion (58%) and bronchial wall thickening (42%). Echocardiography revealed impaired cardiac function in half of cases (51%) and coronary artery abnormalities in 14%. Cardiac MRI showed myocardial oedema in 58%, pericardial effusion in 42% and decreased left ventricular function in 25%. Twenty children required imaging for abdominal symptoms, the commonest abnormalities being free fluid (71%) and terminal ileum wall thickening (57%). Twelve children underwent brain imaging, showing abnormalities in two cases. CONCLUSION: Children with multisystem inflammatory syndrome showed pulmonary, cardiac, abdominal and brain imaging findings, reflecting the multisystem inflammatory disease. Awareness of the imaging features of this disease is important for early diagnosis and treatment.
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COVID-19/diagnóstico por imagen , Pulmón/diagnóstico por imagen , SARS-CoV-2/aislamiento & purificación , Tomografía Computarizada por Rayos X/métodos , COVID-19/diagnóstico , COVID-19/epidemiología , Prueba de Ácido Nucleico para COVID-19 , Niño , Preescolar , Ecocardiografía , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Pandemias , SARS-CoV-2/genética , Síndrome de Respuesta Inflamatoria SistémicaRESUMEN
BACKGROUND: Image sharpness is commonly degraded on cardiac CT images reconstructed using iterative reconstruction algorithms. OBJECTIVE: To compare the image quality of cardiac CT between raw-data-based and model-based iterative reconstruction algorithms developed by the same CT vendor in children and young adults with congenital heart disease. MATERIALS AND METHODS: In 29 patients with congenital heart disease, we reconstructed 39 cardiac CT datasets using raw-data-based and model-based iterative reconstruction algorithms. We performed quantitative analysis of image sharpness using distance25-75% and angle25-75% on a line density profile across an edge of the descending thoracic aorta in addition to CT attenuation, image noise, signal-to-noise ratio and contrast-to-noise ratio. We compared these quantitative image-quality measures between the two algorithms. RESULTS: CT attenuation did not show significant differences between the algorithms (P>0.05) except in the aorta. Image noise was small but significantly higher in the model-based algorithm than in the raw-data-based algorithm (4.8±2.3 Hounsfield units [HU] vs. 4.7±2.1 HU, P<0.014). Signal-to-noise ratio (110.2±50.9 vs. 108.4±50.4, P=0.050) and contrast-to-noise ratio (91.0±45.7 vs. 89.6±45.1, P=0.063) showed marginal significance between the two algorithms. The model-based algorithm showed a significantly smaller distance25-75% (1.4±0.4 mm vs. 1.6±0.3 mm, P<0.001) and a significantly higher angle25-75% (77.0±4.3° vs. 74.1±5.7°, P<0.001) than the raw-data-based algorithm. CONCLUSION: Compared with the raw-data-based algorithm, the model-based iterative reconstruction algorithm demonstrated better image sharpness and higher image noise on cardiac CT in patients with congenital heart disease.
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Algoritmos , Cardiopatías Congénitas/diagnóstico por imagen , Tomografía Computarizada Multidetector , Interpretación de Imagen Radiográfica Asistida por Computador/métodos , Adolescente , Adulto , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos , Relación Señal-RuidoRESUMEN
BACKGROUND: Pulmonary infection with SARS-CoV-2 virus (severe acute respiratory syndrome coronavirus 2; COVID-19) has rapidly spread worldwide to become a global pandemic. OBJECTIVE: To collect paediatric COVID-19 cases worldwide and to summarize both clinical and imaging findings in children who tested positive on polymerase chain reaction testing for SARS-CoV-2. MATERIALS AND METHODS: Data were collected by completion of a standardised case report form submitted to the office of the European Society of Paediatric Radiology from March 12 to April 8, 2020. Chest imaging findings in children younger than 18 years old who tested positive on polymerase chain reaction testing for SARS-CoV-2 were included. Representative imaging studies were evaluated by multiple senior paediatric radiologists from this group with expertise in paediatric chest imaging. RESULTS: Ninety-one children were included (49 males; median age: 6.1 years, interquartile range: 1.0 to 13.0 years, range: 9 days-17 years). Most had mild symptoms, mostly fever and cough, and one-third had coexisting medical conditions. Eleven percent of children presented with severe symptoms and required intensive unit care. Chest radiographs were available in 89% of patients and 10% of them were normal. Abnormal chest radiographs showed mainly perihilar bronchial wall thickening (58%) and/or airspace consolidation (35%). Computed tomography (CT) scans were available in 26% of cases, with the most common abnormality being ground glass opacities (88%) and/or airspace consolidation (58%). Tree in bud opacities were seen in 6 of 24 CTs (25%). Lung ultrasound and chest magnetic resonance imaging were rarely utilized. CONCLUSION: It seems unnecessary to perform chest imaging in children to diagnose COVID-19. Chest radiography can be used in symptomatic children to assess airway infection or pneumonia. CT should be reserved for when there is clinical concern to assess for possible complications, especially in children with coexisting medical conditions.
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Betacoronavirus , Infecciones por Coronavirus/diagnóstico por imagen , Neumonía Viral/diagnóstico por imagen , Radiografía Torácica/métodos , Tomografía Computarizada por Rayos X/métodos , Adolescente , COVID-19 , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Pulmón/diagnóstico por imagen , Masculino , Pandemias , Reproducibilidad de los Resultados , Estudios Retrospectivos , SARS-CoV-2RESUMEN
BACKGROUND: Semiautomatic three-dimensional (3-D) threshold-based cardiac computed tomography (CT) quantification has not been attempted for left ventricular mass. OBJECTIVE: To evaluate the technical feasibility of semiautomatic 3-D threshold-based cardiac CT quantification of left ventricular mass in patients with various degrees of left ventricular hypertrophy. MATERIALS AND METHODS: In 99 patients, cardiac CT was utilized to quantify ventricular volume and mass by using a semiautomatic 3-D threshold-based method. Left ventricular mass values were compared between the end-systole and the end-diastole. Volumetric parameters were compared among three left ventricular hypertrophy groups (definite, borderline, none). The reproducibility was assessed. The t-test, one-way analysis of variance and Pearson correlation were used. RESULTS: There were no technical failures. The left ventricular mass between the two sessions exhibited a small mean difference of 2.3±1.1% (mean±standard deviation). The indexed mass values were significantly higher at the end-systole than at the end-diastole (71.4±42.9 g/m2 vs. 65.9±43.3 g/m2, P<0.001), with significant correlation (R=0.99, P<0.001). The definite group (83.5±41.3 g/m2) showed statistically significantly higher indexed mass values than the borderline and none groups (64.7±26.9 and 55.6±23.9 g/m2, respectively; P<0.03), while demonstrating no statistically significant difference between the latter two groups (P>0.05). Left ventricular volume-mass and mass-volume ratios could be calculated in all three groups. CONCLUSION: CT quantification of left ventricular mass using semiautomatic 3-D threshold-based segmentation is feasible with high reproducibility and the mass values and its ratios with ventricular volumes may be used in patients with various degrees of left ventricular hypertrophy.
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Hipertrofia Ventricular Izquierda/diagnóstico por imagen , Imagenología Tridimensional/métodos , Interpretación de Imagen Radiográfica Asistida por Computador/métodos , Tomografía Computarizada por Rayos X/métodos , Adolescente , Técnicas de Imagen Sincronizada Cardíacas , Niño , Preescolar , Estudios de Factibilidad , Femenino , Humanos , Lactante , Masculino , Reproducibilidad de los Resultados , Estudios RetrospectivosRESUMEN
BACKGROUND: Considering inherent limitations of transthoracic echocardiography, the diagnostic accuracy of cardiac CT in identifying coronary artery anatomy before arterial switch operation needs to be investigated with recently improved coronary artery visibility using electrocardiogram (ECG)-synchronized dual-source CT. OBJECTIVE: To compare diagnostic accuracy between cardiac CT using a dual-source scanner and transthoracic echocardiography in identifying coronary artery anatomy before arterial switch operation in newborns and young infants. MATERIALS AND METHODS: The study included 101 infants (median age 4 days, range 0 days to 10 months; M:F=78:23) who underwent ECG-synchronized cardiac dual-source CT and transthoracic echocardiography before arterial switch operation between July 2011 and December 2016. We evaluated and classified coronary artery anatomy on cardiac CT and transthoracic echocardiography. With the surgical findings as the reference standard, we compared the diagnostic accuracy for identifying coronary artery anatomy between cardiac CT and transthoracic echocardiography. RESULTS: The most common coronary artery pattern was the usual pattern (left coronary artery from sinus 1 and right coronary artery from sinus 2; 64.4%, 65/101), followed by a single coronary artery from sinus 2 and a conal branch from sinus 1 (7.9%, 8/101), the inverted pattern (5.9%, 6/101), the right coronary artery and left anterior descending artery from sinus 1 and the left circumflex artery from sinus 2 (5.9%, 6/101), and others. In 96 infants with surgically proven coronary artery anatomy, the diagnostic accuracy of cardiac CT was significantly higher than that of transthoracic echocardiography (91.7%, 88/96 vs. 54.2%, 52/96; P<0.0001). CONCLUSION: Diagnostic accuracy of cardiac CT is significantly higher than that of echocardiography in identifying coronary artery anatomy before arterial switch operation in newborns and young infants.
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Angiografía por Tomografía Computarizada/métodos , Anomalías de los Vasos Coronarios/diagnóstico por imagen , Ecocardiografía/métodos , Transposición de los Grandes Vasos/diagnóstico por imagen , Operación de Switch Arterial , Electrocardiografía , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Transposición de los Grandes Vasos/cirugíaRESUMEN
BACKGROUND: Combined prospectively electrocardiography (ECG)- and respiratory-triggered sequential cardiac computed tomography (CT) has not been evaluated in free-breathing children. OBJECTIVE: To evaluate the success rate and image quality of combined prospectively ECG- and respiratory-triggered sequential cardiac CT in free-breathing children. MATERIALS AND METHODS: Image quality of combined prospectively ECG- and respiratory-triggered sequential cardiac CT in 870 children (≤5 years of age) was evaluated in terms of severe motion (maximal distance ≥2 mm) and band artifacts (maximal attenuation difference ≥100 Hounsfield units). The success rate of the scan mode was calculated. The causes of failed cases were assessed. Patient-related, radiation and image quality parameters were compared between success and failure groups. RESULTS: Severe motion artifacts were observed in 10.6% (92/870) of patients due to cardiac phase error in 17 (18.5%), patient motion in 12 (13.0%), and unknown causes in 63 (68.5%). Severe band artifacts were seen in 13.2% (115/870) of patients. Combined prospectively ECG- and respiratory-triggered sequential cardiac CT was successfully performed in 78.5% (683/870) of patients, while it failed in 21.5% (187/870). All the evaluated patient-related, radiation and image quality parameters were significantly different (P≤0.001) between success and failure groups except effective dose (P>0.05). CONCLUSION: Additional prospective respiratory triggering can reduce motion artifacts in prospectively ECG-triggered sequential cardiac CT in free-breathing children.
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Técnicas de Imagen Sincronizada Cardíacas , Cardiopatías Congénitas/diagnóstico por imagen , Técnicas de Imagen Sincronizada Respiratorias , Tomografía Computarizada por Rayos X/métodos , Artefactos , Preescolar , Electrocardiografía , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Movimiento , Estudios RetrospectivosRESUMEN
BACKGROUND: The effect of cardiac phase on CT pulmonary vascular volumetry is unknown. OBJECTIVE: To evaluate the effect of cardiac phase on CT pulmonary vascular volume ratio in children and young adults with congenital heart disease. MATERIALS AND METHODS: Thirty-one children and young adults (median age 14 years) with congenital heart disease underwent electrocardiography-synchronized cardiothoracic CT at the end-systolic and end-diastolic phases as well as lung perfusion scintigraphy (n=20) or cardiac MRI (n=11). The author calculated right and left pulmonary vascular volumes by using threshold-based CT volumetry. Right pulmonary vascular volume percentages measured by CT obtained at the end-systolic and end-diastolic phases were compared with corresponding values measured by the reference method (lung perfusion scintigraphy or phase-contrast MRI) by using paired t-test and Bland-Altman analysis. RESULTS: The right pulmonary vascular volume percentages measured by CT were significantly greater at the end-systolic phase than at the end-diastolic phase (64.0±14.1% vs. 61.9±10.7%; P<0.01). The end-systolic CT right pulmonary vascular volume percentages were not significantly different from the corresponding values measured by the reference method (64.0±14.1% vs. 65.3±13.6%; P>0.05), while the end-diastolic vascular volume percentages were significantly smaller than the corresponding values measured by the reference method (61.9±10.7% vs. 65.3±13.6%; P=0.01). Bland-Altman analysis showed a mean difference of 1.4±7.2% for the end-systolic CT, which was significantly smaller than that for the end-diastolic CT (3.4±7.0%; P<0.01). CONCLUSION: The CT pulmonary vascular volume ratio is significantly influenced by the cardiac phase of cardiothoracic CT. The end-systolic phase offers more accurate CT pulmonary vascular volumes than the end-diastolic phase.
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Volumen Sanguíneo , Tomografía Computarizada de Haz Cónico/métodos , Cardiopatías Congénitas/diagnóstico por imagen , Circulación Pulmonar , Adolescente , Técnicas de Imagen Sincronizada Cardíacas , Niño , Preescolar , Femenino , Humanos , Lactante , Imagen por Resonancia Magnética , Masculino , Imagen de Perfusión , Estudios Retrospectivos , Adulto JovenRESUMEN
BACKGROUND: Accurate evaluation of anatomy and ventricular function after the Norwood procedure in hypoplastic left heart syndrome is important for treatment planning and prognostication, but echocardiography and cardiac MRI have limitations. OBJECTIVE: To assess serial changes in anatomy and ventricular function on dual-source cardiac CT after the Norwood procedure for hypoplastic left heart syndrome. MATERIALS AND METHODS: In 14 consecutive patients with hypoplastic left heart syndrome, end-systolic and end-diastolic phase cardiac dual-source CT was performed before and early (average: 1 month) after the Norwood procedure, and repeated late (median: 4.5 months) after the Norwood procedure in six patients. Ventricular functional parameters and indexed morphological measurements including pulmonary artery size, right ventricular free wall thickness, and ascending aorta size on cardiac CT were compared between different time points. Moreover, morphological features including ventricular septal defect, endocardial fibroelastosis and coronary ventricular communication were evaluated on cardiac CT. RESULTS: Right ventricular function and volumes remained unchanged (indexed end-systolic and end-diastolic volumes: 38.9±14.0 vs. 41.1±21.5 ml/m2, P=0.7 and 99.5±30.5 vs. 105.1±33.0 ml/m2, P=0.6; ejection fraction: 60.1±7.3 vs. 63.8±7.0%, P=0.1, and indexed stroke volume: 60.7±18.0 vs. 64.0±15.6 ml/m2, P=0.5) early after the Norwood procedure, but function was decreased (ejection fraction: 64.2±2.6 vs. 58.1±7.1%, P=0.01) and volume was increased (indexed end-systolic and end-diastolic volumes: 39.2±14.9 vs. 68.9±20.6 ml/m2, P<0.003 and 107.8±36.5 vs. 162.9±36.2 ml/m2, P<0.006, and indexed stroke volume: 68.6±21.7 vs. 94.0±21.3 ml/m2, P=0.02) later. Branch pulmonary artery size showed a gradual decrease without asymmetry after the Norwood procedure. Right and left pulmonary artery stenoses were identified in 21.4% (3/14) of the patients. Indexed right ventricular free wall thickness showed a significant increase early after the Norwood procedure (25.5±3.5 vs. 34.8±5.1 mm/m2, P=0.01) and then a significant decrease late after the Norwood procedure (34.8±5.1 vs. 27.2±4.2 mm/m2, P<0.0001). The hypoplastic ascending aorta smaller than 2 mm in diameter was identified in 21.4% (3/14) of the patients. Ventricular septal defect (n=3), endocardial fibroelastosis (n=2) and coronary ventricular communication (n=1) were detected on cardiac CT. CONCLUSION: Cardiac CT can be used to assess serial changes in anatomy and ventricular function after the Norwood procedure in patients with hypoplastic left heart syndrome.
Asunto(s)
Síndrome del Corazón Izquierdo Hipoplásico/diagnóstico por imagen , Síndrome del Corazón Izquierdo Hipoplásico/cirugía , Procedimientos de Norwood , Tomografía Computarizada por Rayos X/métodos , Técnicas de Imagen Sincronizada Cardíacas , Medios de Contraste , Femenino , Humanos , Síndrome del Corazón Izquierdo Hipoplásico/fisiopatología , Recién Nacido , Yopamidol/análogos & derivados , Masculino , Dosis de Radiación , Estudios Retrospectivos , Volumen Sistólico , Función VentricularRESUMEN
BACKGROUND: Clinical utility of myocardial delayed enhancement CT has not been reported in children and young adults. OBJECTIVE: To describe initial experience of myocardial delayed enhancement CT regarding image quality, radiation dose and identification of myocardial lesions in children and young adults. MATERIALS AND METHODS: Between August 2013 and November 2016, 29 consecutive children and young adults (median age 16 months) with suspected coronary artery or myocardial abnormality underwent arterial- and delayed-phase cardiac CT at our institution. We measured CT densities in normal myocardium, left ventricular cavity, and arterial and delayed hypo-enhancing and delayed hyperenhancing myocardial lesions. We then compared the extent of delayed hyperenhancing lesions with delayed-enhancement MRI or thallium single-photon emission CT. RESULTS: Normal myocardium and left ventricular cavity showed significantly higher CT numbers on arterial-phase CT than on delayed-phase CT (t-test, P<0.0001). Contrast-to-noise ratios of the arterial and delayed hypo-enhancing and delayed hyperenhancing lesions on CT were 26.7, 17.6 and 18.7, respectively. Delayed-phase CT findings were equivalent to those of delayed-enhancement MRI in all cases (7/7) and to those of thallium single-photon emission CT in 70% (7/10). CONCLUSION: Myocardial delayed-enhancement CT can be added to evaluate myocardial lesions in select children and young adults with suspected coronary artery or myocardial abnormality.
Asunto(s)
Cardiomiopatías/diagnóstico por imagen , Anomalías de los Vasos Coronarios/diagnóstico por imagen , Tomografía Computarizada por Rayos X/métodos , Adolescente , Adulto , Artefactos , Técnicas de Imagen Sincronizada Cardíacas , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Tomografía Computarizada por Tomografía de Emisión de Positrones , Dosis de Radiación , Estudios RetrospectivosRESUMEN
BACKGROUND: Lung perfusion scintigraphy is regarded as the gold standard for evaluating differential lung perfusion ratio in congenital heart disease. OBJECTIVE: To compare cardiac CT with lung perfusion scintigraphy for estimated pulmonary vascular volume ratio in patients with congenital heart disease. MATERIALS AND METHODS: We included 52 children and young adults (median age 4 years, range 2 months to 28 years; 31 males) with congenital heart disease who underwent cardiac CT and lung perfusion scintigraphy without an interim surgical or transcatheter intervention and within 1 year. We calculated the right and left pulmonary vascular volumes using threshold-based CT volumetry. Then we compared right pulmonary vascular volume percentages at cardiac CT with right lung perfusion percentages at lung perfusion scintigraphy by using paired t-test and Bland-Altman analysis. RESULTS: The right pulmonary vascular volume percentages at cardiac CT (66.3 ± 14.0%) were significantly smaller than the right lung perfusion percentages at lung perfusion scintigraphy (69.1 ± 15.0%; P=0.001). Bland-Altman analysis showed a mean difference of -2.8 ± 5.8% and 95% limits of agreement (-14.1%, 8.5%) between these two variables. CONCLUSION: Cardiac CT, in a single examination, can offer pulmonary vascular volume ratio in addition to pulmonary artery anatomy essential for evaluating peripheral pulmonary artery stenosis in patients with congenital heart disease. However there is a wide range of agreement between cardiac CT and lung perfusion scintigraphy.