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1.
Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups.
Bioorg Med Chem Lett;
22(4): 1779-83, 2012 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22257889
2.
Safety and Efficacy of AGN-190584 in Individuals With Presbyopia: The GEMINI 1 Phase 3 Randomized Clinical Trial.
JAMA Ophthalmol;
140(4): 363-371, 2022 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35238902
3.
Solubilization of Cyclosporine in Topical Ophthalmic Formulations: Preformulation Risk Assessment on a New Solid Form.
J Pharm Sci;
108(10): 3233-3239, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31228492
4.
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation.
J Neurosci;
27(13): 3366-74, 2007 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-17392452
5.
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem;
51(6): 1637-48, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18278858
6.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem;
51(6): 1681-94, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18321037
7.
A New Hydrate of Cyclosporine: Structural and Physicochemical Characterization.
J Pharm Sci;
107(12): 3070-3079, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30114405
8.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem;
49(16): 4981-91, 2006 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16884310
9.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem;
49(19): 5671-86, 2006 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16970394
10.
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1).
ACS Med Chem Lett;
2(2): 102-6, 2011 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900287
11.
Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.
ACS Med Chem Lett;
2(2): 107-12, 2011 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900288
12.
The co-crystal approach to improve the exposure of a water-insoluble compound: AMG 517 sorbic acid co-crystal characterization and pharmacokinetics.
J Pharm Sci;
97(9): 3942-56, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18214948
13.
Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans.
Pain;
136(1-2): 202-10, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18337008
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