Detalles de la búsqueda
1.
Design, Synthesis, Molecular docking, and biological evaluation of novel 2,3-diaryl-1,3-thiazolidine-4-one derivatives as potential anti-inflammatory and cytotoxic agents.
Bioorg Chem;
133: 106411, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36801792
2.
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Bioorg Chem;
120: 105616, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35078049
3.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Bioorg Chem;
112: 104960, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-34020242
4.
Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.
Bioorg Chem;
107: 104522, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33317838
5.
Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases.
Bioorg Chem;
106: 104510, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33279248
6.
Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Bioorg Chem;
116: 105363, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34555629
7.
Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents.
J Enzyme Inhib Med Chem;
36(1): 1313-1333, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34154478
8.
Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities.
J Enzyme Inhib Med Chem;
36(1): 15-33, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33103497
9.
Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR.
Molecules;
26(21)2021 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34770832
10.
In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases.
Molecules;
26(13)2021 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34209011
11.
Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism.
Molecules;
26(21)2021 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34771085
12.
Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies.
Molecules;
26(21)2021 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-34770990
13.
Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities.
Bioorg Chem;
94: 103371, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31708230
14.
Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity.
Bioorg Chem;
105: 104369, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33091670
15.
Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives.
Bioorg Chem;
100: 103933, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32446119
16.
Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation.
Bioorg Chem;
102: 104090, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32683176
17.
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors.
Bioorg Chem;
104: 104260, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32920363
18.
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.
Bioorg Chem;
99: 103782, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32229348
19.
Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors.
Molecules;
25(9)2020 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32397330
20.
Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action.
Bioorg Chem;
92: 103224, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31491568