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1.

Exosomes.

Pegtel, D Michiel; Gould, Stephen J.

Annu Rev Biochem; 88: 487-514, 2019 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-31220978

2.

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

Ebert, Peter J R; Cheung, Jeanne; Yang, Yagai; McNamara, Erin; Hong, Rebecca; Moskalenko, Marina; Gould, Stephen E; Maecker, Heather; Irving, Bryan A; Kim, Jeong M; Belvin, Marcia; Mellman, Ira.

Immunity; 44(3): 609-621, 2016 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-26944201

3.

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.

Biehs, Brian; Dijkgraaf, Gerrit J P; Piskol, Robert; Alicke, Bruno; Boumahdi, Soufiane; Peale, Franklin; Gould, Stephen E; de Sauvage, Frederic J.

Nature; 562(7727): 429-433, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30297801

4.

Degron tagging of BleoR and other antibiotic-resistance genes selects for higher expression of linked transgenes and improved exosome engineering.

Tsai, Shang Jui; Ai, Yiwei; Guo, Chenxu; Gould, Stephen J.

J Biol Chem; 298(5): 101846, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35314197

5.

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes.

Fordjour, Francis K; Guo, Chenxu; Ai, Yiwei; Daaboul, George G; Gould, Stephen J.

J Biol Chem; 298(10): 102394, 2022 10.

Artículo en Inglés | MEDLINE | ID: mdl-35988652

6.

Choice of selectable marker affects recombinant protein expression in cells and exosomes.

Guo, Chenxu; Fordjour, Francis K; Tsai, Shang Jui; Morrell, James C; Gould, Stephen J.

J Biol Chem; 297(1): 100838, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-34051235

7.

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.

Tsai, Shang Jui; Atai, Nadia A; Cacciottolo, Mafalda; Nice, Justin; Salehi, Arjang; Guo, Chenxu; Sedgwick, Alanna; Kanagavelu, Saravana; Gould, Stephen J.

J Biol Chem; 297(5): 101266, 2021 11.

Artículo en Inglés | MEDLINE | ID: mdl-34600888

8.

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility.

Vitorino, Philip; Yeung, Stacey; Crow, Ailey; Bakke, Jesse; Smyczek, Tanya; West, Kristina; McNamara, Erin; Eastham-Anderson, Jeffrey; Gould, Stephen; Harris, Seth F; Ndubaku, Chudi; Ye, Weilan.

Nature; 519(7544): 425-30, 2015 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-25799996

9.

Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses.

Cubas, Rafael; Moskalenko, Marina; Cheung, Jeanne; Yang, Michelle; McNamara, Erin; Xiong, Huizhong; Hoves, Sabine; Ries, Carola H; Kim, Jeong; Gould, Stephen.

J Immunol; 201(8): 2273-2286, 2018 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-30209192

10.

PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.

Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Smith, Tunde; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Yauch, Robert L.

Proc Natl Acad Sci U S A; 114(46): 12249-12254, 2017 11 14.

Artículo en Inglés | MEDLINE | ID: mdl-29087303

11.

Patient Perception of Orthopedic Surgeon Reimbursement.

Boudreau, Sellers C; Dombrowsky, Alexander R; Arguello, Alexandra M; Gould, Stephen; Brabston, Eugene W; Ponce, Brent A; Momaya, Amit M.

South Med J; 113(4): 191-197, 2020 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-32239232

12.

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.

Bronner, Sarah M; Merrick, Karl A; Murray, Jeremy; Salphati, Laurent; Moffat, John G; Pang, Jodie; Sneeringer, Christopher J; Dompe, Nicholas; Cyr, Patrick; Purkey, Hans; Boenig, Gladys de Leon; Li, Jun; Kolesnikov, Aleksandr; Larouche-Gauthier, Robin; Lai, Kwong Wah; Shen, Xiaoli; Aubert-Nicol, Samuel; Chen, Yi-Chen; Cheong, Jonathan; Crawford, James J; Hafner, Marc; Haghshenas, Pouyan; Jakalian, Araz; Leclerc, Jean-Philippe; Lim, Ngiap-Kie; O'Brien, Tom; Plise, Emile G; Shalan, Hadil; Sturino, Claudio; Wai, John; Xiao, Yang; Yin, Jianping; Zhao, Liang; Gould, Stephen; Olivero, Alan; Heffron, Timothy P.

Bioorg Med Chem Lett; 29(16): 2294-2301, 2019 08 15.

Artículo en Inglés | MEDLINE | ID: mdl-31307887

13.

Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model.

Li, Ling; Piontek, Klaus; Ishida, Masaharu; Fausther, Michel; Dranoff, Jonathan A; Fu, Rongdang; Mezey, Esteban; Gould, Stephen J; Fordjour, Francis K; Meltzer, Stephen J; Sirica, Alphonse E; Selaru, Florin M.

Hepatology; 65(2): 501-514, 2017 02.

Artículo en Inglés | MEDLINE | ID: mdl-27474881

14.

Cell biology: Organelle formation from scratch.

Hettema, Ewald H; Gould, Stephen J.

Nature; 542(7640): 174-175, 2017 02 09.

Artículo en Inglés | MEDLINE | ID: mdl-28146478

15.

Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.

Li, Jinze; Morinello, Eric; Larsen, Thomas; Frost, Denzil; Caro, Ivor; Gould, Stephen; Wong, Lisa; Hendricks, Angela; Dybdal, Noel; Dambach, Donna; Schutten, Melissa.

Regul Toxicol Pharmacol; 92: 382-389, 2018 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-29278695

16.

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.

Salphati, Laurent; Alicke, Bruno; Heffron, Timothy P; Shahidi-Latham, Sheerin; Nishimura, Merry; Cao, Tim; Carano, Richard A; Cheong, Jonathan; Greve, Joan; Koeppen, Hartmut; Lau, Shari; Lee, Leslie B; Nannini-Pepe, Michelle; Pang, Jodie; Plise, Emile G; Quiason, Cristine; Rangell, Linda; Zhang, Xiaolin; Gould, Stephen E; Phillips, Heidi S; Olivero, Alan G.

Drug Metab Dispos; 44(12): 1881-1889, 2016 12.

Artículo en Inglés | MEDLINE | ID: mdl-27638506

17.

Translational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice.

Wong, Harvey; Gould, Stephen E.

Drug Discov Today Technol; 21-22: 51-56, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-27978988

18.

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Wang, Lan; Stanley, Mark; Boggs, Jason W; Crawford, Terry D; Bravo, Brandon J; Giannetti, Anthony M; Harris, Seth F; Magnuson, Steven R; Nonomiya, Jim; Schmidt, Stephen; Wu, Ping; Ye, Weilan; Gould, Stephen E; Murray, Lesley J; Ndubaku, Chudi O; Chen, Huifen.

Bioorg Med Chem Lett; 24(18): 4546-4552, 2014 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-25139565

19.

Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2.

Blake, James F; Gaudino, John J; De Meese, Jason; Mohr, Peter; Chicarelli, Mark; Tian, Hongqi; Garrey, Rustam; Thomas, Allen; Siedem, Christopher S; Welch, Michael B; Kolakowski, Gabrielle; Kaus, Robert; Burkard, Michael; Martinson, Matthew; Chen, Huifen; Dean, Brian; Dudley, Danette A; Gould, Stephen E; Pacheco, Patricia; Shahidi-Latham, Sheerin; Wang, Weiru; West, Kristina; Yin, Jianping; Moffat, John; Schwarz, Jacob B.

Bioorg Med Chem Lett; 24(12): 2635-9, 2014 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-24813737

20.

A paracrine requirement for hedgehog signalling in cancer.

Yauch, Robert L; Gould, Stephen E; Scales, Suzie J; Tang, Tracy; Tian, Hua; Ahn, Christina P; Marshall, Derek; Fu, Ling; Januario, Thomas; Kallop, Dara; Nannini-Pepe, Michelle; Kotkow, Karen; Marsters, James C; Rubin, Lee L; de Sauvage, Frederic J.

Nature; 455(7211): 406-10, 2008 Sep 18.

Artículo en Inglés | MEDLINE | ID: mdl-18754008

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