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1.

Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity.

Straub, Leon G; Efthymiou, Vissarion; Grandl, Gerald; Balaz, Miroslav; Challa, Tenagne Delessa; Truscello, Luca; Horvath, Carla; Moser, Caroline; Rachamin, Yael; Arnold, Myrtha; Sun, Wenfei; Modica, Salvatore; Wolfrum, Christian.

Diabetologia; 62(11): 2094-2105, 2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31309261

2.

Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet.

Grandl, Gerald; Straub, Leon; Rudigier, Carla; Arnold, Myrtha; Wueest, Stephan; Konrad, Daniel; Wolfrum, Christian.

J Physiol; 596(19): 4597-4609, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30089335

3.

Hairless promotes PPARÎ³ expression and is required for white adipogenesis.

Kumpf, Susann; Mihlan, Michael; Goginashvili, Alexander; Grandl, Gerald; Gehart, Helmuth; Godel, Aurélie; Schmidt, Juliane; Müller, Julius; Bezzi, Marco; Ittner, Arne; Guccione, Ernesto; Wolfrum, Christian; Ricci, Romeo.

EMBO Rep; 13(11): 1012-20, 2012 Nov 06.

Artículo en Inglés | MEDLINE | ID: mdl-22964757

4.

Global, neuronal or ß cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.

Grandl, Gerald; Collden, Gustav; Feng, Jin; Bhattacharya, Sreya; Klingelhuber, Felix; Schomann, Leopold; Bilekova, Sara; Xu, Weiwei; Far, Fataneh Fathi; Tost, Monica; Gruber, Tim; Bastidas-Ponce, Aimée; Zhang, Qian; Novikoff, Aaron; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Garcia-Caceres, Cristina; Feuchtinger, Annette; Tschöp, Matthias H; Krahmer, Natalie; Lickert, Heiko; Müller, Timo D.

Nat Metab; 6(3): 448-457, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38418586

5.

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.

Akindehin, Seun; Liskiewicz, Arkadiusz; Liskiewicz, Daniela; Bernecker, Miriam; Garcia-Caceres, Cristina; Drucker, Daniel J; Finan, Brian; Grandl, Gerald; Gutgesell, Robert; Hofmann, Susanna M; Khalil, Ahmed; Liu, Xue; Cota, Perla; Bakhti, Mostafa; Czarnecki, Oliver; Bastidas-Ponce, Aimée; Lickert, Heiko; Kang, Lingru; Maity, Gandhari; Novikoff, Aaron; Parlee, Sebastian; Pathak, Ekta; Schriever, Sonja C; Sterr, Michael; Ussar, Siegfried; Zhang, Qian; DiMarchi, Richard; Tschöp, Matthias H; Pfluger, Paul T; Douros, Jonathan D; Müller, Timo D.

Mol Metab; 83: 101915, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38492844

6.

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Ständer, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L; He, Yantao; Knerr, Patrick J; Yang, Bin; Hogendorf, Wouter F J; Zhang, Shiqi; Hofmann, Susanna M; Finan, Brian; DiMarchi, Richard D; Tschöp, Matthias H; Douros, Jonathan D; Müller, Timo D.

Nat Metab; 5(12): 2075-2085, 2023 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-37946085

7.

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.

Quarta, Carmelo; Stemmer, Kerstin; Novikoff, Aaron; Yang, Bin; Klingelhuber, Felix; Harger, Alex; Bakhti, Mostafa; Bastidas-Ponce, Aimee; Baugé, Eric; Campbell, Jonathan E; Capozzi, Megan; Clemmensen, Christoffer; Collden, Gustav; Cota, Perla; Douros, Jon; Drucker, Daniel J; DuBois, Barent; Feuchtinger, Annette; Garcia-Caceres, Cristina; Grandl, Gerald; Hennuyer, Nathalie; Herzig, Stephan; Hofmann, Susanna M; Knerr, Patrick J; Kulaj, Konxhe; Lalloyer, Fanny; Lickert, Heiko; Liskiewicz, Arek; Liskiewicz, Daniela; Maity, Gandhari; Perez-Tilve, Diego; Prakash, Sneha; Sanchez-Garrido, Miguel A; Zhang, Qian; Staels, Bart; Krahmer, Natalie; DiMarchi, Richard D; Tschöp, Matthias H; Finan, Brian; Müller, Timo D.

Nat Metab; 4(8): 1071-1083, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35995995

8.

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.

Novikoff, Aaron; O'Brien, Shannon L; Bernecker, Miriam; Grandl, Gerald; Kleinert, Maximilian; Knerr, Patrick J; Stemmer, Kerstin; Klingenspor, Martin; Zeigerer, Anja; DiMarchi, Richard; Tschöp, Matthias H; Finan, Brian; Calebiro, Davide; Müller, Timo D.

Mol Metab; 49: 101181, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33556643

9.

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Zhang, Qian; Delessa, Challa Tenagne; Augustin, Robert; Bakhti, Mostafa; Colldén, Gustav; Drucker, Daniel J; Feuchtinger, Annette; Caceres, Cristina Garcia; Grandl, Gerald; Harger, Alexandra; Herzig, Stephan; Hofmann, Susanna; Holleman, Cassie Lynn; Jastroch, Martin; Keipert, Susanne; Kleinert, Maximilian; Knerr, Patrick J; Kulaj, Konxhe; Legutko, Beata; Lickert, Heiko; Liu, Xue; Luippold, Gerd; Lutter, Dominik; Malogajski, Emilija; Medina, Marta Tarquis; Mowery, Stephanie A; Blutke, Andreas; Perez-Tilve, Diego; Salinno, Ciro; Sehrer, Laura; DiMarchi, Richard D; Tschöp, Matthias H; Stemmer, Kerstin; Finan, Brian; Wolfrum, Christian; Müller, Timo D.

Cell Metab; 33(4): 833-844.e5, 2021 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-33571454

10.

Gut Peptide Agonism in the Treatment of Obesity and Diabetes.

Grandl, Gerald; Novikoff, Aaron; DiMarchi, Richard; Tschöp, Matthias H; Müller, Timo D.

Compr Physiol; 10(1): 99-124, 2019 12 18.

Artículo en Inglés | MEDLINE | ID: mdl-31853954

11.

Hemostasis, endothelial stress, inflammation, and the metabolic syndrome.

Grandl, Gerald; Wolfrum, Christian.

Semin Immunopathol; 40(2): 215-224, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29209827

12.

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun, Wenfei; Dong, Hua; Becker, Anton S; Dapito, Dianne H; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A; von Meyenn, Ferdinand; Wolfrum, Christian.

Nat Med; 24(11): 1776, 2018 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-30087435

13.

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun, Wenfei; Dong, Hua; Becker, Anton S; Dapito, Dianne H; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A; von Meyenn, Ferdinand; Wolfrum, Christian.

Nat Med; 24(11): 1777, 2018 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-30087436

14.

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Sun, Wenfei; Dong, Hua; Becker, Anton S; Dapito, Dianne H; Modica, Salvatore; Grandl, Gerald; Opitz, Lennart; Efthymiou, Vissarion; Straub, Leon G; Sarker, Gitalee; Balaz, Miroslav; Balazova, Lucia; Perdikari, Aliki; Kiehlmann, Elke; Bacanovic, Sara; Zellweger, Caroline; Peleg-Raibstein, Daria; Pelczar, Pawel; Reik, Wolf; Burger, Irene A; von Meyenn, Ferdinand; Wolfrum, Christian.

Nat Med; 24(9): 1372-1383, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-29988127

15.

Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Clemmensen, Christoffer; Jall, Sigrid; Kleinert, Maximilian; Quarta, Carmelo; Gruber, Tim; Reber, Josefine; Sachs, Stephan; Fischer, Katrin; Feuchtinger, Annette; Karlas, Angelos; Simonds, Stephanie E; Grandl, Gerald; Loher, Daniela; Sanchez-Quant, Eva; Keipert, Susanne; Jastroch, Martin; Hofmann, Susanna M; Nascimento, Emmani B M; Schrauwen, Patrick; Ntziachristos, Vasilis; Cowley, Michael A; Finan, Brian; Müller, Timo D; Tschöp, Matthias H.

Nat Commun; 9(1): 4975, 2018 11 20.

Artículo en Inglés | MEDLINE | ID: mdl-30459311

16.

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Clemmensen, Christoffer; Jall, Sigrid; Kleinert, Maximilian; Quarta, Carmelo; Gruber, Tim; Reber, Josefine; Sachs, Stephan; Fischer, Katrin; Feuchtinger, Annette; Karlas, Angelos; Simonds, Stephanie E; Grandl, Gerald; Loher, Daniela; Sanchez-Quant, Eva; Keipert, Susanne; Jastroch, Martin; Hofmann, Susanna M; Nascimento, Emmani B M; Schrauwen, Patrick; Ntziachristos, Vasilis; Cowley, Michael A; Finan, Brian; Müller, Timo D; Tschöp, Matthias H.

Nat Commun; 9(1): 4304, 2018 10 23.

Artículo en Inglés | MEDLINE | ID: mdl-30353008

17.

Adipocytes at the Core of Bone Function.

Grandl, Gerald; Wolfrum, Christian.

Cell Stem Cell; 20(6): 739-740, 2017 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-28575686

18.

Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Ravichandran, Meenakshi; Grandl, Gerald; Ristow, Michael.

Cell Metab; 26(4): 585-587, 2017 Oct 03.

Artículo en Inglés | MEDLINE | ID: mdl-28978421

19.

Depot specific differences in the adipogenic potential of precursors are mediated by collagenous extracellular matrix and Flotillin 2 dependent signaling.

Grandl, Gerald; Müller, Sebastian; Moest, Hansjörg; Moser, Caroline; Wollscheid, Bernd; Wolfrum, Christian.

Mol Metab; 5(10): 937-947, 2016 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-27689006

20.

A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism.

Barstow, Buz; Agapakis, Christina M; Boyle, Patrick M; Grandl, Gerald; Silver, Pamela A; Wintermute, Edwin H.

J Biol Eng; 5: 7, 2011 May 26.

Artículo en Inglés | MEDLINE | ID: mdl-21615937

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Antioxidants protect against diabetes by improving glucose homeostasis in mouse models of inducible insulin resistance and obesity.

Short-term feeding of a ketogenic diet induces more severe hepatic insulin resistance than an obesogenic high-fat diet.

Hairless promotes PPARÎ³ expression and is required for white adipogenesis.

Global, neuronal or ß cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity.

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice.

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.

GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice.

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists.

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Gut Peptide Agonism in the Treatment of Obesity and Diabetes.

Hemostasis, endothelial stress, inflammation, and the metabolic syndrome.

Author Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Publisher Correction: Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.

Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Adipocytes at the Core of Bone Function.

Dietary Carbohydrates Impair Healthspan and Promote Mortality.

Depot specific differences in the adipogenic potential of precursors are mediated by collagenous extracellular matrix and Flotillin 2 dependent signaling.

A synthetic system links FeFe-hydrogenases to essential E. coli sulfur metabolism.