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1.
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.
Bioorg Med Chem Lett;
73: 128891, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35842205
2.
Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc Natl Acad Sci U S A;
113(13): E1796-805, 2016 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26976583
3.
Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.
Br J Haematol;
177(2): 271-282, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28295194
4.
Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.
J Am Chem Soc;
137(7): 2695-703, 2015 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25625324
5.
Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.
J Biol Chem;
288(46): 33124-35, 2013 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24072709
6.
Docking covalent inhibitors: a parameter free approach to pose prediction and scoring.
J Chem Inf Model;
54(7): 1932-40, 2014 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24916536
7.
Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J Med Chem;
66(15): 10473-10496, 2023 08 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37427891
8.
Docking performance of the glide program as evaluated on the Astex and DUD datasets: a complete set of glide SP results and selected results for a new scoring function integrating WaterMap and glide.
J Comput Aided Mol Des;
26(6): 787-99, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22576241
9.
The Role of Marriage in Fighting HIV: A Quantitative Illustration for Malawi.
Am Econ Rev;
107(5): 158-62, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29553239
10.
Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution.
J Comput Aided Mol Des;
24(6-7): 591-604, 2010 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-20354892
11.
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
Cell Metab;
29(1): 174-182.e5, 2019 01 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30244972
12.
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.
J Med Chem;
51(5): 1459-63, 2008 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-18269227
13.
Spatial scale, abundance and the species-energy relationship in British birds.
J Anim Ecol;
77(2): 395-405, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18005031
14.
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209.
J Mol Biol;
357(4): 1184-201, 2006 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16483599
15.
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.
J Med Chem;
50(17): 4177-85, 2007 Aug 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17672447
16.
A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
J Med Chem;
50(10): 2408-14, 2007 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-17455929
17.
An experiment on the impact of a neonicotinoid pesticide on honeybees: the value of a formal analysis of the data.
Environ Sci Eur;
29(1): 4, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28163992
18.
A novel inhibitor of active protein kinase G attenuates chronic inflammatory and osteoarthritic pain.
Pain;
158(5): 822-832, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28059868
19.
Accelerating drug discovery through tight integration of expert molecular design and predictive scoring.
Curr Opin Struct Biol;
43: 38-44, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-27816785
20.
3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists.
Neuropharmacology;
51(1): 52-9, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16631211