Detalles de la búsqueda
1.
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
Biochem J;
431(1): 51-61, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20642456
2.
Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Biochem J;
422(3): 463-71, 2009 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-19570037
3.
Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1.
J Med Chem;
63(22): 13878-13898, 2020 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33147410
4.
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Bioorg Med Chem Lett;
19(4): 1071-4, 2009 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19171483
5.
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Bioorg Med Chem;
16(1): 542-59, 2008 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18024134
6.
Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.
J Med Chem;
50(20): 4845-53, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17845018
7.
Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active.
Biochim Biophys Acta;
1750(1): 82-92, 2005 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15893506
8.
Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
J Med Chem;
49(10): 2939-52, 2006 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-16686536
9.
Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
J Med Chem;
49(18): 5424-33, 2006 Sep 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-16942016
10.
3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
J Med Chem;
48(1): 134-40, 2005 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-15634007
11.
Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1.
J Med Chem;
48(6): 1806-12, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771426
12.
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
J Med Chem;
48(23): 7243-52, 2005 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16279783
13.
Eulogy to Mathias P. Mertes, 1932-1989.
Med Res Rev;
29(1): 1-2, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19058131
14.
Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.
J Med Chem;
47(18): 4483-93, 2004 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-15317460
15.
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
J Med Chem;
47(1): 37-44, 2004 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14695818
16.
The NH---FC dipole orientation effect for pendant exocyclic CH(2)F.
Org Lett;
4(21): 3557-60, 2002 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12375886
17.
Exploring the active site of phenylethanolamine N-methyltransferase with 1,2,3,4-tetrahydrobenz[h]isoquinoline inhibitors.
Bioorg Med Chem;
15(3): 1298-310, 2007 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17126018
18.
Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
Bioorg Med Chem Lett;
15(23): 5319-23, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16169723
19.
Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors.
Bioorg Med Chem;
13(4): 1261-73, 2005 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15670935
20.
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.
Biochemistry;
44(51): 16875-85, 2005 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16363801