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1.
An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin.
Org Biomol Chem;
11(28): 4680-5, 2013 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23752953
2.
Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.
J Pharmacol Exp Ther;
324(2): 507-16, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18025247
3.
N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.
J Med Chem;
50(5): 1078-82, 2007 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-17298049
4.
Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.
J Med Chem;
49(13): 3770-3, 2006 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16789734
5.
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Protein Sci;
14(12): 3039-47, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16322581
6.
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
J Med Chem;
48(12): 3980-90, 2005 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15943472
7.
5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel inhibitors of adenosine kinase.
J Med Chem;
46(24): 5249-57, 2003 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-14613327
8.
The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.
Bioorg Med Chem Lett;
17(6): 1803-7, 2007 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17234407
9.
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
Bioorg Med Chem Lett;
17(7): 1961-5, 2007 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17267221
10.
From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae.
Chem Biol Drug Des;
69(6): 395-404, 2007 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-17581233
11.
Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Bioorg Med Chem Lett;
16(23): 6078-81, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973360
12.
Structure-based optimization of MurF inhibitors.
Chem Biol Drug Des;
67(1): 58-65, 2006 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-16492149
13.
Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.
Bioorg Med Chem Lett;
15(10): 2653-8, 2005 May 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-15863336
14.
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives.
Bioorg Med Chem Lett;
15(11): 2716-9, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911248
15.
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.
Bioorg Med Chem Lett;
15(11): 2803-7, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911258
16.
Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.
Biochemistry;
42(3): 718-27, 2003 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-12534284
17.
Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.
Bioorg Med Chem Lett;
14(12): 3299-302, 2004 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15149694
18.
Structure-activity relationships of novel potent MurF inhibitors.
Bioorg Med Chem Lett;
14(1): 267-70, 2004 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-14684340
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