1.
Org Biomol Chem
; 9(11): 4144-9, 2011 Jun 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-21494711
RESUMEN
In a program aimed at discovering novel protein kinase inhibitors, a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines has been developed exploiting the isocyanide-based multicomponent Blackburn reaction, followed by a nucleophilic aromatic substitution with ammonia or primary and secondary amines. The potential of the reported scaffold is strengthened by the inhibition of STAT5-dependent transcription displayed by four of the synthesized compounds.