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This study aims to assess the effect of the COVID-19 pandemic on the consumption of self-care products for pediculosis capitis management, in Portugal. A segmented regression analysis of interrupted time series (March 2020) was performed from January 2017 to August 2023 to analyze the short- and long-term impact of the COVID-19 pandemic on the consumption of pediculicides and related products. Monthly rates of absolute consumption were estimated by community pharmacies' dispensing records. Portuguese municipalities were organized into quintiles according to their purchasing power index and percentage of youth, to study the association of these social and demographic variables on the sale of these products. COVID-19 pandemic significantly reduced the sales of products indicated for pediculosis. Since the start of the pandemic, an absolute decrease of 21.0 thousand packages was observed in the monthly average consumption (p < 0.0001) compared to the pre-pandemic period. After this reduction, the average monthly trend increased in the pandemic period in comparison with the previous period, although not significant (267.0 packages per month, p = 0.1102). Regions with higher disposable income and more young people were associated with higher sales of these products. The outbreak of the COVID-19 pandemic has had a notable impact on the sales of self-care products for pediculosis capitis in Portugal, in the short term. The lockdowns and other isolation measures implemented to control the spread of the virus may have led to a decrease in the number of head lice cases, consequently resulting in a reduction in sales of products.
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COVID-19 , Análisis de Series de Tiempo Interrumpido , Infestaciones por Piojos , Autocuidado , Portugal/epidemiología , Humanos , COVID-19/epidemiología , COVID-19/prevención & control , Infestaciones por Piojos/epidemiología , SARS-CoV-2 , Animales , Dermatosis del Cuero Cabelludo/epidemiología , Insecticidas , Adolescente , PandemiasRESUMEN
Observational, cross-sectional prevalence studies are costly and time-consuming. The development of indirect methods estimating prevalence used to obtain faster, less-expensive, and more robust results would be an advantage for several healthcare applications. This study aimed to use the drug dispensing data from community pharmacies to estimate the prevalence of Type 2 Diabetes mellitus (T2DM) in the Portuguese population. A cross-sectional study was conducted using a database of dispensed medicines with an indication for Diabetes mellitus in 2018 and 2021, stratified by geographic region. The methodology was based on a sequential method of acquiring prevalence estimates obtained through exposure to medicines using the daily doses defined per thousand inhabitants per day and adjusted to the rate of adherence to therapy, prescription patterns, and concomitance of antidiabetic drugs. The estimated overall T2DM prevalence in 2018 was 13.9%, and it was 14.2% for 2021. The results show the increased consumption of antidiabetic drugs, with fixed-dose combination antidiabetics and new antidiabetics being particularly important in 2021. This work allowed for the development of a model to obtain the estimated prevalence of T2DM based on drug consumption, using a simple, fast, and robust method that is in line with the available evidence. However, with the recent expanding indications for new antidiabetics, the inclusion of further data in the model needs to be studied.
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INTRODUCTION: Worldwide, demographic ageing is a major social, economic and health challenge. Despite the increase in life expectancy, elderly often live with multiple chronic conditions, exposing them to multiple medications. Concerns have been raised about the growing issue of inappropriate long-term usage of proton-pump inhibitors (PPI), which have been associated with adverse outcomes and increased healthcare costs. Deprescribing is a recommended intervention to reduce or withdraw medicines that might be causing harm or might no longer be of benefit. This protocol details a trial to assess the effectiveness and cost-effectiveness of a collaborative deprescribing intervention of PPI among community-dwelling elderly, involving community pharmacists and general practitioners. METHODS AND ANALYSIS: A pragmatic, multicentre, two-arm, non-randomised controlled trial of a structured PPI collaborative deprescribing intervention in the primary care setting with a 6-month follow-up will be conducted. Patients must be 65 years old or older, live in the community and have been using PPI for more than 8 weeks. We hypothesize that the intervention will reduce the PPI usage in the intervention group compared to the control group. The primary outcome is the successful discontinuation or dose decrease of any PPI, defined as a statistically significant absolute 20% reduction in medication use between the intervention and control groups at 3- and 6-month follow-ups. An economic evaluation will be conducted alongside the trial. This study was approved by the Ethics Research Committee of Nova Medical School, NOVA University of Lisbon and by the Ethics Committee from the Local Health Unit Alto Minho, Portugal. DISCUSSION: This pragmatic trial will provide evidence on the effectiveness and cost-effectiveness of a patient-centred collaborative deprescribing intervention in the community setting in Portugal. It will also inform improvements for the development of future multi-faceted interventions that aim to optimise medication for the community-dwelling elderly. CLINICAL TRIAL REGISTRATION: ISRCTN 49637686.
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Deprescripciones , Inhibidores de la Bomba de Protones , Anciano , Humanos , Análisis Costo-Beneficio , Vida Independiente , Inhibidores de la Bomba de Protones/uso terapéutico , Protones , Ensayos Clínicos Pragmáticos como Asunto , Ensayos Clínicos Controlados no Aleatorios como AsuntoRESUMEN
Introduction: Although psychoactive medicines (PMed) are needed in several psychiatric conditions, their use and misuse bear risks. We aimed at estimating the prevalence of PMed use and misuse. Methods: Data on all PMed prescribed in 2017 and dispensed in community pharmacies of the Lisbon and Tagus Valley region of Portugal (ARSLVT) were extracted from ARSLVT medicines' dispensing database. For 21 PMed among prescription opioids, benzodiazepines and z-drugs (BZDR), antidepressants (AD) and anticonvulsants (AC), we estimated the number of users of each PMed, and assessed PMed misuse by a set of proxy indicators for studying this practice: chronic use (use of ≥180 DDD during the study period) of PMed intended for short-term treatments, concomitant use of several PMed, in particular if involving long-term (≥ 30 days) opioid analgesic (OA) use, and doctor shopping (patients consulting several physicians in order to have access to a quantity higher than intended by each prescriber). Data were analysed using descriptive statistics and hypothesis testing, and multivariate logistic regression was used to explore potential factors affecting long-term concomitant treatment of chronic OA with other PMed. Results: PMed use prevalence was 21.7%: 6.6% for OA, 12.7% for benzodiazepines (BZD), 5.3% for AD and 2.8% for AC. BZDR were mainly prescribed in primary care and OA in hospital outpatients. Chronic use of PMed was observed in 25%, especially with sertraline and buprenorphine for opioid use disorder (long-term treatment), and lorazepam (short-term treatment). About 56.6% of OA chronic users were long-term concurrent users with other PMed, mainly BZDR. Risk of abuse was low for BZDR, whilst four opioids had meaningful doctor shopping indicators - fentanyl, opioid use disorder buprenorphine, morphine and hydromorphone. Conclusions: BZD are the main PMed used in ARSLVT, often chronically, especially lorazepam. Prevalence of OA use is low, although with higher risk of misuse than BZDR. Concomitant use of several PMed is frequent.
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Objetivo: Este artículo describe el proceso realizado para asegurar que un cuestionario de calidad de vida específico para diabetes [el «Audit of Diabetes Dependent Quality of Life» (ADDQoL)] mantiene sus propiedades psicométricas después de una adaptación transcultural del inglés al portugués. Métodos: Usando farmacias comunitarias de Lisboa, se reclutó a 100 pacientes mediante un diseño transversal. Se pidió a los pacientes que respondieran el cuestionario una vez. Se sometió a los datos a un análisis factorial, y se realizaron análisis de consistencia interna y de poder discriminatorio. Resultados: En la muestra portuguesa, 17 ítems se incluyeron en un factor con pesos de más de 0,43. El ítem «preocupaciones sobre el futuro» peso poco en este factor, pero si se retiraba la consistencia interna sufría un muy ligero incremento (alfa de Cronbach=0,89 a 0,90). Se detectó un mayor impacto negativo en 16 de los 18 dominios de calidad de vida para los pacientes tratados con insulina, y también se encontró un mayor impacto negativo en 14 de los 18 dominios en pacientes con complicaciones diabéticas. El dominio «libertad para comer» mostró el mayor impacto negativo en todos los subgrupos de pacientes, tal y como describía la versión original, así que se conservaron las propiedades psicométricas. Además, los pacientes sin complicaciones diabéticas comunicaron peor calidad de vida (mayor impacto negativo) en el primer ítem, calidad de vida actual (Z=-2,25; p=0,024); mientras que los pacientes con insulina comunicaron un mayor impacto negativo de la diabetes en su calidad e vida (Z=-1,94; p=0,053). Conclusión: Generalmente, la versión portuguesa para Portugal del ADDQoL ha demostrado mantener sus propiedades psicométricas originales y podría recomendarse para su uso y posterior evaluación en posteriores estudios (AU)
Objective: This paper describes the processes involved to ensure a diabetes-specific quality of life questionnaire [the «Audit of Diabetes Dependent Quality of Life» (ADDQoL)] retained the psychometric properties following cross-cultural adaptation from English to Portuguese. Methods: One hundred patients were recruited through community pharmacies located in Lisbon through a cross sectional study design. Patients were asked to respond to the questionnaire on one occasion in time. Data were subjected to factor analysis, and internal consistency and discriminatory power analyses were undertaken. Results: In the Portuguese sample, 17 items loaded into one factor, with factor loadings above 0.43. The item «worries about the future» loaded weekly into this factor but if removed its internal consistency estimate increased very slightly (Cronbach's alpha=0.89 to 0.90). A greater negative impact of diabetes on 16 of the 18 quality of life domains was detected for insulin-treated patients, together with a greater negative impact on 14 of the 18 quality of life domains for patients with diabetic complications. The domain «freedom to eat» revealed the greatest negative impact in all patient subgroups, as described in its original version, so the psychometric properties were retained. Additionally, patients without diabetic complications reported a worse quality of life (greater negative impact) on the first overview item, present quality of life (Z=-2.25; p=0.024); whilst patients on insulin reported a greater negative impact of diabetes on their quality of life (Z=-1.94; p=0.053). Conclusion: Generally, the Portuguese version for Portugal of the ADDQoL has shown to maintain its original psychometric properties, and could be recommended for use and further evaluation in subsequent studies (AU)