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1.
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett;
23(12): 3531-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23668988
2.
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J Med Chem;
61(3): 989-1000, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29227683
3.
Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
J Med Chem;
60(23): 9490-9507, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29112410
4.
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Mol Cancer Ther;
16(5): 871-878, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28223423
5.
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
J Med Chem;
57(3): 770-92, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24405419
6.
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
J Med Chem;
56(12): 4921-37, 2013 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23617784
7.
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J Med Chem;
56(16): 6413-33, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23859118
8.
Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.
J Med Chem;
55(11): 5536-45, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22591441
9.
Potent and selective aminopyrimidine-based B-Raf inhibitors with favorable physicochemical and pharmacokinetic properties.
J Med Chem;
55(6): 2869-81, 2012 Mar 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-22335519
10.
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
Sci Transl Med;
4(164): 164ra161, 2012 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23241745
11.
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
J Med Chem;
55(22): 9416-33, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22985112
12.
Pyrazolopyridine Inhibitors of B-Raf(V600E). Part 1: The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors.
ACS Med Chem Lett;
2(5): 342-7, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900315
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