Detalles de la búsqueda
1.
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.
Bioorg Med Chem;
26(12): 3133-3144, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29705377
2.
Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.
Bioorg Med Chem;
26(5): 1035-1049, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29398442
3.
6-Phenoxy-2-phenylbenzoxazoles, novel inhibitors of receptor for advanced glycation end products (RAGE).
Bioorg Med Chem;
23(15): 4919-4935, 2015 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26051601
4.
Two ß-strands of RAGE participate in the recognition and transport of amyloid-ß peptide across the blood brain barrier.
Biochem Biophys Res Commun;
439(2): 252-7, 2013 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-23973487
5.
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain.
Pharmaceuticals (Basel);
16(7)2023 Jul 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513874
6.
Discovery of potent indazole-based human glutaminyl cyclase (QC) inhibitors as Anti-Alzheimer's disease agents.
Eur J Med Chem;
244: 114837, 2022 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36265279
7.
Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design.
Eur J Med Chem;
226: 113819, 2021 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34536669
8.
Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.
J Med Chem;
64(1): 370-384, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33385210
9.
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer's disease by inhibiting necroptosis.
Sci Adv;
7(3)2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33523877
10.
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
J Med Chem;
63(1): 418-424, 2020 01 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31702924
11.
Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer's Agents by Structure-Based Design.
J Med Chem;
62(17): 8011-8027, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31411468
12.
Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a ß-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.
J Med Chem;
61(1): 396-402, 2018 01 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29161514
13.
Effects of methamphetamine on single unit activity in rat medial prefrontal cortex in vivo.
Neural Plast;
2007: 29821, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18288241
14.
Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design.
J Med Chem;
60(6): 2573-2590, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234463
15.
Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system.
PLoS One;
12(6): e0177933, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28586343
16.
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
J Med Chem;
49(6): 2028-36, 2006 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-16539391
17.
Transgenic potato expressing Abeta reduce Abeta burden in Alzheimer's disease mouse model.
FEBS Lett;
579(30): 6737-44, 2005 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-16310782
18.
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
J Med Chem;
46(14): 3116-26, 2003 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-12825950
19.
Mesenchymal stem cells enhance autophagy and increase ß-amyloid clearance in Alzheimer disease models.
Autophagy;
10(1): 32-44, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24149893
20.
Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE).
Eur J Med Chem;
79: 128-42, 2014 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-24727489