RESUMEN
The anti-implantation and mid-term abortifacient effects exhibited by administration of Inula viscosa leaf extracts, were studied in rats. The aqueous extract administered i.p. on day 1-6 of gestation, totally diminished fetal implantation and caused a significant (P<0.05) reduction in the number of corpora lutea and blood progesterone levels. Meanwhile, administration on day 13-15 of gestation exhibited mid-term abortion. Furthermore, petroleum ether and dichloromethane, but not methanol, extracts exhibited pronounced abortifacient effects. The results of this study are in agreement with the traditional reputation of this plant as abortifacient. Further, the plant possesses anti-implantational and luteolytic effects.
Asunto(s)
Abortivos/farmacología , Magnoliopsida/química , Extractos Vegetales/farmacología , Animales , Cuerpo Lúteo/efectos de los fármacos , Implantación del Embrión/efectos de los fármacos , Femenino , Inula , Masculino , Extractos Vegetales/química , Extractos Vegetales/toxicidad , Hojas de la Planta/química , Hojas de la Planta/toxicidad , Embarazo , Progesterona/sangre , RatasRESUMEN
Over a 10-year-period extending from January 1976 to September 1986, 800 peripheral vascular injuries were surgically treated at the American University of Beirut Medical Centre. Of these, 150 were operated on because of injury to the femoral vessels. Bullets were the commonest wounding agents (60% of cases). Thirty-seven patients had a femoral artery injury, 27 a femoral vein injury and 86 combined femoral artery and vein damage. Twenty-three per cent of the patients had an associated fracture of the femur. Patients with fractures had an 11% amputation rate compared with 1% for those without fractures. Our data reveals the importance of venous reconstruction in the presence of an arterial injury instead of its ligation (P less than 0.05), particularly when there is an associated fracture of the femur. Thirty-seven per cent of patients were in shock on admission (systolic BP 90 mmHg). The amputation rate in these patients was 6.8% in contrast to 1% in the haemodynamically stable group (P less than 0.05). The overall amputation rate was 3.3%. Complications occurred in 36.6% of patients and the mortality was 4.0%.
Asunto(s)
Arteria Femoral/lesiones , Vena Femoral/lesiones , Guerra , Adolescente , Adulto , Anciano , Amputación Quirúrgica , Niño , Preescolar , Femenino , Arteria Femoral/cirugía , Vena Femoral/cirugía , Humanos , Líbano , Ligadura , Masculino , Persona de Mediana Edad , Heridas por Arma de Fuego/cirugíaRESUMEN
Two cases of clear cell sarcoma of tendons and aponeuroses, one with prominent melanogenesis, are reported. One tumour arose in the left buttock of a young male and the other in the left fourth toe of a young female. Both had a rapid fatal course with local and distant metastases. Electron microscopy shows melanosomes in one case, suggesting a melanotic origin.