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1.
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Bioorg Med Chem Lett;
27(4): 1109-1114, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28111141
2.
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Bioorg Med Chem Lett;
27(11): 2559-2566, 2017 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28431879
3.
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
J Pharmacol Exp Ther;
359(1): 194-206, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27432892
4.
Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Bioorg Med Chem Lett;
26(9): 2339-43, 2016 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27017115
5.
Discovery of a potent and selective ROMK inhibitor with improved pharmacokinetic properties based on an octahydropyrazino[2,1-c][1,4]oxazine scaffold.
Bioorg Med Chem Lett;
26(23): 5695-5702, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27839686
6.
Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one.
Bioorg Med Chem Lett;
23(21): 5829-32, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24075732
7.
Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
J Med Chem;
64(11): 7691-7701, 2021 06 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34038119
8.
Early echocardiographic predictors of outcomes in the mouse transverse aortic constriction heart failure model.
J Pharmacol Toxicol Methods;
84: 93-101, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27956205
9.
Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model.
SAGE Open Med;
5: 2050312117700057, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28491305
10.
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
ACS Med Chem Lett;
7(7): 697-701, 2016 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27437080
11.
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
ACS Med Chem Lett;
6(7): 747-52, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191360
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