Relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease among people in Inner Mongolia of China.

OBJECTIVE: To explore the relationship of inflammation and endothelial dysfunction with risks to cardiovascular disease (CVD). METHODS: Blood pressure, body weight, body height, waist circumference and lifestyle risk factors were measured and studied among 2589 participants in Inner Mongolia of China, and biomarkers of inflammation and endothelial dysfunction including high-sensitivity C-reactive protein (hsCRP), soluble inter-cellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), and angiotensin II were investigated. RESULTS: Subjects with metabolic risk factors for CVD had higher levels of hsCRP, sE-selectin and sICAM-1 than those without such risk factors (all P<0.05). Levels of all biomarkers positively and significantly increased with aggregation of the metabolic risk factors among the subjects (all P for trend <0.001). Data from the multivariate analysis showed that participants with high levels of hsCRP [odds ratio (OR): 1.96, 95% confidence interval (CI): 1.52-2.53], sE-selectin (OR: 1.35, 95% CI: 1.05-1.72), and angiotensin II (OR: 1.81, 95% CI: 1.40-2.33) were more likely to develop hypertension; participants with high levels of hsCRP (OR: 2.33, 95% CI: 1.85-2.94), sE-selectin (OR: 1.24, 95% CI: 1.00-1.54), and sICAM-1 (OR: 1.70, 95% CI: 1.30-2.22) were more likely to develop dyslipidemia, and those with high levels of hsCRP (OR: 2.95, 95% CI: 2.27-3.83) and sICAM-1(OR: 2.80, 95% CI: 2.06-3.80) were more likely to develop hyperglycemia. CONCLUSION: Biomarkers of inflammation and endothelial dysfunction were separately associated with relevant metabolic risk factors for CVD. And appropriate measures should be taken to control inflammation and improve endothelial function among individuals with different metabolic risk factors for CVD.

[The application of circular stapler in extraperitoneal colostomy].

OBJECTIVE: To evaluate the clinical and application value of circular stapler in extraperitoneal colostomy. METHODS: Retrospective analysis was made to 22 cases that experienced extraperitoneal colostomy with circular stapler from Match 2008 to March 2009 in the department of colon and anal surgery of the first hospital of Jilin University. RESULTS: The length of surgery was (15 +/- 5) min when circular stapler- assisted extraperitoneal colostomy was used, and all of the colostomies were successfully completed during the first procedure. No complications occurred after surgery, such as stoma bleeding, necrosis, infection, retraction, stenosis, intestinal obstruction and hernia beside the stoma etc. Colostomy size of the uniform, beautiful shape formation. Although there were three cases requiring hemostasis due to anastomotic bleeding that occurred during the operation. About 3 months later, staples of the stoma fell off by themselves. All patients were followed up for 6 to 24 months after operation, form and function of colostomy are well. CONCLUSION: The popularization of the application of circular stapler in extraperitoneal colostomy is important and worthwhile for its obvious advantages such as simple operation, good stoma appearance and reduced complications.