Detalles de la búsqueda
1.
Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study.
Bioorg Chem;
102: 104092, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32707280
2.
Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrrolo[2,3-b]pyridine derivatives as potential anti-tumor agents.
Bioorg Chem;
94: 103474, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31859010
3.
Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51.
Bioorg Med Chem;
26(12): 3242-3253, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29748145
4.
Discovery of 2-(4-Substituted-piperidin/piperazine-1-yl)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-quinazoline-2,4-diamines as PAK4 Inhibitors with Potent A549 Cell Proliferation, Migration, and Invasion Inhibition Activity.
Molecules;
23(2)2018 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29443911
5.
Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study.
Bioorg Med Chem;
25(13): 3500-3511, 2017 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28502459
6.
Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies.
Bioorg Med Chem;
25(2): 750-758, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27955926
7.
Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion.
Org Biomol Chem;
14(32): 7676-90, 2016 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27454186
8.
Discovery of novel N,N-3-phenyl-3-benzylaminopropionanilides as potent inhibitors of cholesteryl ester transfer protein in vivo.
Bioorg Med Chem;
24(8): 1811-8, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26993745
9.
Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor.
Bioorg Med Chem;
24(8): 1589-97, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27010500
10.
Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors.
Org Biomol Chem;
13(12): 3803-18, 2015 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25705811
11.
Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1).
Bioorg Med Chem;
23(6): 1356-65, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25684424
12.
An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.
Sci Transl Med;
16(738): eadi0979, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38478629
13.
Optically activated MEK1/2 inhibitors (Opti-MEKi) as potential antimelanoma agents.
Eur J Med Chem;
251: 115236, 2023 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36924668
14.
Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.
Eur J Med Chem;
238: 114451, 2022 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35617855
15.
Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors.
Eur J Med Chem;
188: 112024, 2020 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31923858
16.
Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor.
Eur J Med Chem;
186: 111878, 2020 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31757524
17.
Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents.
Eur J Med Chem;
183: 111716, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31550660
18.
The therapeutic potential of CETP inhibitors: a patent review.
Expert Opin Ther Pat;
28(4): 331-340, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29424255
19.
Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors.
Eur J Med Chem;
155: 197-209, 2018 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29886323
20.
Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.
J Med Chem;
61(1): 265-285, 2018 01 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29190083