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1.

Complement genes contribute sex-biased vulnerability in diverse disorders.

Kamitaki, Nolan; Sekar, Aswin; Handsaker, Robert E; de Rivera, Heather; Tooley, Katherine; Morris, David L; Taylor, Kimberly E; Whelan, Christopher W; Tombleson, Philip; Loohuis, Loes M Olde; Boehnke, Michael; Kimberly, Robert P; Kaufman, Kenneth M; Harley, John B; Langefeld, Carl D; Seidman, Christine E; Pato, Michele T; Pato, Carlos N; Ophoff, Roel A; Graham, Robert R; Criswell, Lindsey A; Vyse, Timothy J; McCarroll, Steven A.

Nature; 582(7813): 577-581, 2020 06.

Artículo en Inglés | MEDLINE | ID: mdl-32499649

2.

Association between systemic lupus erythematosus and myasthenia gravis: A population-based National Study.

Igoe, Ann; Merjanah, Sali; Harley, Isaac T W; Clark, Dennis H; Sun, Celi; Kaufman, Kenneth M; Harley, John B; Kaelber, David C; Scofield, R Hal.

Clin Immunol; 260: 109810, 2024 03.

Artículo en Inglés | MEDLINE | ID: mdl-37949200

3.

Epstein-Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci.

Hong, Ted; Parameswaran, Sreeja; Donmez, Omer A; Miller, Daniel; Forney, Carmy; Lape, Michael; Saint Just Ribeiro, Mariana; Liang, Jun; Edsall, Lee E; Magnusen, Albert F; Miller, William; Chepelev, Iouri; Harley, John B; Zhao, Bo; Kottyan, Leah C; Weirauch, Matthew T.

Genome Res; 31(12): 2185-2198, 2021 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-34799401

4.

Novel EDGE encoding method enhances ability to identify genetic interactions.

Hall, Molly A; Wallace, John; Lucas, Anastasia M; Bradford, Yuki; Verma, Shefali S; Müller-Myhsok, Bertram; Passero, Kristin; Zhou, Jiayan; McGuigan, John; Jiang, Beibei; Pendergrass, Sarah A; Zhang, Yanfei; Peissig, Peggy; Brilliant, Murray; Sleiman, Patrick; Hakonarson, Hakon; Harley, John B; Kiryluk, Krzysztof; Van Steen, Kristel; Moore, Jason H; Ritchie, Marylyn D.

PLoS Genet; 17(6): e1009534, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-34086673

5.

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.

Thomas, Minta; Sakoda, Lori C; Hoffmeister, Michael; Rosenthal, Elisabeth A; Lee, Jeffrey K; van Duijnhoven, Franzel J B; Platz, Elizabeth A; Wu, Anna H; Dampier, Christopher H; de la Chapelle, Albert; Wolk, Alicja; Joshi, Amit D; Burnett-Hartman, Andrea; Gsur, Andrea; Lindblom, Annika; Castells, Antoni; Win, Aung Ko; Namjou, Bahram; Van Guelpen, Bethany; Tangen, Catherine M; He, Qianchuan; Li, Christopher I; Schafmayer, Clemens; Joshu, Corinne E; Ulrich, Cornelia M; Bishop, D Timothy; Buchanan, Daniel D; Schaid, Daniel; Drew, David A; Muller, David C; Duggan, David; Crosslin, David R; Albanes, Demetrius; Giovannucci, Edward L; Larson, Eric; Qu, Flora; Mentch, Frank; Giles, Graham G; Hakonarson, Hakon; Hampel, Heather; Stanaway, Ian B; Figueiredo, Jane C; Huyghe, Jeroen R; Minnier, Jessica; Chang-Claude, Jenny; Hampe, Jochen; Harley, John B; Visvanathan, Kala; Curtis, Keith R; Offit, Kenneth.

Am J Hum Genet; 107(3): 432-444, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32758450

6.

Reanalysis of eMERGE phase III sequence variants in 10,500 participants and infrastructure to support the automated return of knowledge updates.

Zouk, Hana; Yu, Wanfeng; Oza, Andrea; Hawley, Megan; Vijay Kumar, Prathik K; Koch, Christopher; Mahanta, Lisa M; Harley, John B; Jarvik, Gail P; Karlson, Elizabeth W; Leppig, Kathleen A; Myers, Melanie F; Prows, Cynthia A; Williams, Marc S; Weiss, Scott T; Lebo, Matthew S; Rehm, Heidi L.

Genet Med; 24(2): 454-462, 2022 02.

Artículo en Inglés | MEDLINE | ID: mdl-34906510

7.

Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians.

Molineros, Julio E; Looger, Loren L; Kim, Kwangwoo; Okada, Yukinori; Terao, Chikashi; Sun, Celi; Zhou, Xu-Jie; Raj, Prithvi; Kochi, Yuta; Suzuki, Akari; Akizuki, Shuji; Nakabo, Shuichiro; Bang, So-Young; Lee, Hye-Soon; Kang, Young Mo; Suh, Chang-Hee; Chung, Won Tae; Park, Yong-Beom; Choe, Jung-Yoon; Shim, Seung-Cheol; Lee, Shin-Seok; Zuo, Xiaoxia; Yamamoto, Kazuhiko; Li, Quan-Zhen; Shen, Nan; Porter, Lauren L; Harley, John B; Chua, Kek Heng; Zhang, Hong; Wakeland, Edward K; Tsao, Betty P; Bae, Sang-Cheol; Nath, Swapan K.

PLoS Genet; 15(4): e1008092, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-31022184

8.

Medical Records-Based Genetic Studies of the Complement System.

Khan, Atlas; Shang, Ning; Petukhova, Lynn; Zhang, Jun; Shen, Yufeng; Hebbring, Scott J; Moncrieffe, Halima; Kottyan, Leah C; Namjou-Khales, Bahram; Knevel, Rachel; Raychaudhuri, Soumya; Karlson, Elizabeth W; Harley, John B; Stanaway, Ian B; Crosslin, David; Denny, Joshua C; Elkind, Mitchell S V; Gharavi, Ali G; Hripcsak, George; Weng, Chunhua; Kiryluk, Krzysztof.

J Am Soc Nephrol; 32(8): 2031-2047, 2021 08.

Artículo en Inglés | MEDLINE | ID: mdl-33941608

9.

Validation of low-coverage whole-genome sequencing for mitochondrial DNA variants suggests mitochondrial DNA as a genetic cause of preterm birth.

Yang, Zeyu; Slone, Jesse; Wang, Xinjian; Zhan, Jack; Huang, Yongbo; Namjou, Bahram; Kaufman, Kenneth M; Pauciulo, Michael; Harley, John B; Muglia, Louis J; Chepelev, Iouri; Huang, Taosheng.

Hum Mutat; 42(12): 1602-1614, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-34467602

10.

Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.

Laufer, Vincent A; Tiwari, Hemant K; Reynolds, Richard J; Danila, Maria I; Wang, Jelai; Edberg, Jeffrey C; Kimberly, Robert P; Kottyan, Leah C; Harley, John B; Mikuls, Ted R; Gregersen, Peter K; Absher, Devin M; Langefeld, Carl D; Arnett, Donna K; Bridges, S Louis.

Hum Mol Genet; 28(5): 858-874, 2019 03 01.

Artículo en Inglés | MEDLINE | ID: mdl-30423114

11.

Evaluation of the MC4R gene across eMERGE network identifies many unreported obesity-associated variants.

Namjou, Bahram; Stanaway, Ian B; Lingren, Todd; Mentch, Frank D; Benoit, Barbara; Dikilitas, Ozan; Niu, Xinnan; Shang, Ning; Shoemaker, Ashley H; Carey, David J; Mirshahi, Tooraj; Singh, Rajbir; Nestor, Jordan G; Hakonarson, Hakon; Denny, Joshua C; Crosslin, David R; Jarvik, Gail P; Kullo, Iftikhar J; Williams, Marc S; Harley, John B.

Int J Obes (Lond); 45(1): 155-169, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-32952152

12.

Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysis.

Kawai, Vivian K; Shi, Mingjian; Liu, Ge; Feng, QiPing; Wei, WeiQi; Chung, Cecilia P; Walunas, Theresa L; Gordon, Adam S; Linneman, James G; Hebbring, Scott J; Harley, John B; Cox, Nancy J; Roden, Dan M; Stein, C Michael; Mosley, Jonathan D.

Lupus; 30(8): 1264-1272, 2021 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-33977795

13.

Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.

Hanscombe, Ken B; Morris, David L; Noble, Janelle A; Dilthey, Alexander T; Tombleson, Philip; Kaufman, Kenneth M; Comeau, Mary; Langefeld, Carl D; Alarcon-Riquelme, Marta E; Gaffney, Patrick M; Jacob, Chaim O; Sivils, Kathy L; Tsao, Betty P; Alarcon, Graciela S; Brown, Elizabeth E; Croker, Jennifer; Edberg, Jeff; Gilkeson, Gary; James, Judith A; Kamen, Diane L; Kelly, Jennifer A; McCune, Joseph; Merrill, Joan T; Petri, Michelle; Ramsey-Goldman, Rosalind; Reveille, John D; Salmon, Jane E; Scofield, Hal; Utset, Tammy; Wallace, Daniel J; Weisman, Michael H; Kimberly, Robert P; Harley, John B; Lewis, Cathryn M; Criswell, Lindsey A; Vyse, Timothy J.

Hum Mol Genet; 27(21): 3813-3824, 2018 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-30085094

14.

Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.

Jog, Neelakshi R; McClain, Micah T; Heinlen, Latisha D; Gross, Timothy; Towner, Rheal; Guthridge, Joel M; Axtell, Robert C; Pardo, Gabriel; Harley, John B; James, Judith A.

J Autoimmun; 106: 102332, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31515129

15.

Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen.

Ghodke-Puranik, Yogita; Imgruet, Molly; Dorschner, Jessica M; Shrestha, Prakriti; McCoy, Kaci; Kelly, Jennifer A; Marion, Miranda; Guthridge, Joel M; Langefeld, Carl D; Harley, John B; James, Judith A; Sivils, Kathy L; Niewold, Timothy B.

Cytokine; 132: 154631, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-30685201

16.

Complete Tracheal Ring Deformity. A Translational Genomics Approach to Pathogenesis.

Sinner, Debora I; Carey, Brenna; Zgherea, Daniela; Kaufman, K M; Leesman, Lauren; Wood, Robert E; Rutter, Michael J; de Alarcon, Alessandro; Elluru, Ravindhra G; Harley, John B; Whitsett, Jeffrey A; Trapnell, Bruce C.

Am J Respir Crit Care Med; 200(10): 1267-1281, 2019 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-31215789

17.

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Li, He; Reksten, Tove Ragna; Ice, John A; Kelly, Jennifer A; Adrianto, Indra; Rasmussen, Astrid; Wang, Shaofeng; He, Bo; Grundahl, Kiely M; Glenn, Stuart B; Miceli-Richard, Corinne; Bowman, Simon; Lester, Sue; Eriksson, Per; Eloranta, Maija-Leena; Brun, Johan G; Gøransson, Lasse G; Harboe, Erna; Guthridge, Joel M; Kaufman, Kenneth M; Kvarnström, Marika; Cunninghame Graham, Deborah S; Patel, Ketan; Adler, Adam J; Farris, A Darise; Brennan, Michael T; Chodosh, James; Gopalakrishnan, Rajaram; Weisman, Michael H; Venuturupalli, Swamy; Wallace, Daniel J; Hefner, Kimberly S; Houston, Glen D; Huang, Andrew J W; Hughes, Pamela J; Lewis, David M; Radfar, Lida; Vista, Evan S; Edgar, Contessa E; Rohrer, Michael D; Stone, Donald U; Vyse, Timothy J; Harley, John B; Gaffney, Patrick M; James, Judith A; Turner, Sean; Alevizos, Ilias; Anaya, Juan-Manuel; Rhodus, Nelson L; Segal, Barbara M.

PLoS Genet; 13(6): e1006820, 2017 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-28640813

18.

Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis.

Kottyan, Leah C; Maddox, Avery; Braxton, Julian R; Stucke, Emily M; Mukkada, Vince; Putnam, Philip E; Abonia, J Pablo; Chehade, Mirna; Wood, Robert A; Pesek, Robbie D; Vickery, Brian P; Furuta, Glenn T; Dawson, Peter; Sampson, Hugh A; Martin, Lisa J; Kelly, Jennifer A; Kimberly, Robert P; Sivils, Kathy; Gaffney, Patrick M; Kaufman, Kenneth; Harley, John B; Rothenberg, Marc E.

Genes Immun; 20(4): 281-292, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-29904099

19.

Response to Li and Hopper.

Thomas, Minta; Sakoda, Lori C; Hoffmeister, Michael; Rosenthal, Elisabeth A; Lee, Jeffrey K; van Duijnhoven, Franzel J B; Platz, Elizabeth A; Wu, Anna H; Dampier, Christopher H; de la Chapelle, Albert; Wolk, Alicja; Joshi, Amit D; Burnett-Hartman, Andrea; Gsur, Andrea; Lindblom, Annika; Castells, Antoni; Win, Aung Ko; Namjou, Bahram; Van Guelpen, Bethany; Tangen, Catherine M; He, Qianchuan; Li, Christopher I; Schafmayer, Clemens; Joshu, Corinne E; Ulrich, Cornelia M; Bishop, D Timothy; Buchanan, Daniel D; Schaid, Daniel; Drew, David A; Muller, David C; Duggan, David; Crosslin, David R; Albanes, Demetrius; Giovannucci, Edward L; Larson, Eric; Qu, Flora; Mentch, Frank; Giles, Graham G; Hakonarson, Hakon; Hampel, Heather; Stanaway, Ian B; Figueiredo, Jane C; Huyghe, Jeroen R; Minnier, Jessica; Chang-Claude, Jenny; Hampe, Jochen; Harley, John B; Visvanathan, Kala; Curtis, Keith R; Offit, Kenneth.

Am J Hum Genet; 108(3): 527-529, 2021 03 04.

Artículo en Inglés | MEDLINE | ID: mdl-33667396

20.

Therapy for Multisystem Inflammatory Syndrome in Children.

Harley, John B.

N Engl J Med; 385(13): e42, 2021 Sep 23.

Artículo en Inglés | MEDLINE | ID: mdl-34379918

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