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1.

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds, Louise E; Watson, Alan R; Baker, Marianne; Jones, Tania A; D'Amico, Gabriela; Robinson, Stephen D; Joffre, Carine; Garrido-Urbani, Sarah; Rodriguez-Manzaneque, Juan Carlos; Martino-Echarri, Estefanía; Aurrand-Lions, Michel; Sheer, Denise; Dagna-Bricarelli, Franca; Nizetic, Dean; McCabe, Christopher J; Turnell, Andrew S; Kermorgant, Stephanie; Imhof, Beat A; Adams, Ralf; Fisher, Elizabeth M C; Tybulewicz, Victor L J; Hart, Ian R; Hodivala-Dilke, Kairbaan M.

Nature; 465(7299): 813-7, 2010 Jun 10.

Artículo en Inglés | MEDLINE | ID: mdl-20535211

2.

Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases.

Naidoo, Kalnisha; Jones, Richard; Dmitrovic, Branko; Wijesuriya, Nilukshi; Kocher, Hemant; Hart, Ian R; Crnogorac-Jurcevic, Tatjana.

J Pathol; 226(5): 756-63, 2012 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-22081483

3.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang, Siu Man; Brown, Louise; Lin, Kuang; Liu, Li; Piper, Kim; O'Toole, Edel A; Grose, Richard; Hart, Ian R; Garrod, David R; Fortune, Farida; Wan, Hong.

J Pathol; 227(1): 81-93, 2012 May.

Artículo en Inglés | MEDLINE | ID: mdl-22294297

4.

ß3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.

Brunetta, Ivan; Casalotti, Stefano O; Hart, Ian R; Forge, Andrew; Reynolds, Louise E.

BMC Cell Biol; 13: 5, 2012 Mar 17.

Artículo en Inglés | MEDLINE | ID: mdl-22424110

5.

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-ß-catenin signaling to slow tumor progression.

Froeling, Fieke E M; Feig, Christine; Chelala, Claude; Dobson, Richard; Mein, Charles E; Tuveson, David A; Clevers, Hans; Hart, Ian R; Kocher, Hemant M.

Gastroenterology; 141(4): 1486-97, 1497.e1-14, 2011 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-21704588

6.

Clinical and functional significance of α9ß1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.

Allen, Michael D; Vaziri, Reza; Green, Michael; Chelala, Claude; Brentnall, Adam R; Dreger, Sally; Vallath, Sabarinath; Nitch-Smith, Harriet; Hayward, Jane; Carpenter, Robert; Holliday, Deborah L; Walker, Rosemary A; Hart, Ian R; Jones, J Louise.

J Pathol; 223(5): 646-58, 2011 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-21341269

7.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Moutasim, Karwan A; Jenei, Veronika; Sapienza, Karen; Marsh, Daniel; Weinreb, Paul H; Violette, Shelia M; Lewis, Mark P; Marshall, John F; Fortune, Farida; Tilakaratne, Waninayaka M; Hart, Ian R; Thomas, Gareth J.

J Pathol; 223(3): 366-77, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-21171082

8.

Stromal features are predictive of disease mortality in oral cancer patients.

Marsh, Daniel; Suchak, Krishna; Moutasim, Karwan A; Vallath, Sabarinath; Hopper, Colin; Jerjes, Waseem; Upile, Tahwinder; Kalavrezos, Nicholas; Violette, Shelia M; Weinreb, Paul H; Chester, Kerry A; Chana, Jagdeep S; Marshall, John F; Hart, Ian R; Hackshaw, Allan K; Piper, Kim; Thomas, Gareth J.

J Pathol; 223(4): 470-81, 2011 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-21294121

9.

alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.

Reynolds, Louise E; Conti, Francesco J; Silva, Rita; Robinson, Stephen D; Iyer, Vandana; Rudling, Rob; Cross, Barbara; Nye, Emma; Hart, Ian R; Dipersio, C Michael; Hodivala-Dilke, Kairbaan M.

J Clin Invest; 118(3): 965-74, 2008 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-18246199

10.

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

da Silva, Rita Graça; Tavora, Bernardo; Robinson, Stephen D; Reynolds, Louise E; Szekeres, Charles; Lamar, John; Batista, Sílvia; Kostourou, Vassiliki; Germain, Mitchel A; Reynolds, Andrew R; Jones, Dylan T; Watson, Alan R; Jones, Janet L; Harris, Adrian; Hart, Ian R; Iruela-Arispe, M Luisa; Dipersio, C Michael; Kreidberg, Jordan A; Hodivala-Dilke, Kairbaan M.

Am J Pathol; 177(3): 1534-48, 2010 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-20639457

11.

High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.

Saha, Antonio; Ellison, David; Thomas, Gareth J; Vallath, Sabarinath; Mather, Stephen J; Hart, Ian R; Marshall, John F.

J Pathol; 222(1): 52-63, 2010 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-20629113

12.

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

Coughlan, Lynda; Vallath, Sabari; Saha, Antonio; Flak, Magdalena; McNeish, Iain A; Vassaux, Georges; Marshall, John F; Hart, Ian R; Thomas, Gareth J.

J Virol; 83(13): 6416-28, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19369326

13.

Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells.

Froeling, Fieke E M; Mirza, Tariq A; Feakins, Roger M; Seedhar, Angela; Elia, George; Hart, Ian R; Kocher, Hemant M.

Am J Pathol; 175(2): 636-48, 2009 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-19608876

14.

Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation.

Lai-Cheong, Joey E; Parsons, Maddy; Tanaka, Akio; Ussar, Siegfried; South, Andrew P; Gomathy, Sethuraman; Mee, John B; Barbaroux, Jean-Baptiste; Techanukul, Tanasit; Almaani, Noor; Clements, Suzanne E; Hart, Ian R; McGrath, John A.

Am J Pathol; 175(4): 1431-41, 2009 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-19762710

15.

New evidence for tumour embolism as a mode of metastasis.

Hart, Ian R.

J Pathol; 219(3): 275-6, 2009 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-19768739

16.

Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness.

Dicara, Danielle; Burman, Alison; Clark, Stuart; Berryman, Stephen; Howard, Mark J; Hart, Ian R; Marshall, John F; Jackson, Terry.

J Virol; 82(3): 1537-46, 2008 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-18045932

17.

HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.

Ramsay, Alan G; Keppler, Melanie D; Jazayeri, Mona; Thomas, Gareth J; Parsons, Maddy; Violette, Shelia; Weinreb, Paul; Hart, Ian R; Marshall, John F.

Cancer Res; 67(11): 5275-84, 2007 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-17545607

18.

Ability to acquire drug resistance arises early during the tumorigenesis process.

Yagüe, Ernesto; Arance, Ana; Kubitza, Loïc; O'Hare, Michael; Jat, Parmjit; Ogilvie, Caroline M; Hart, Ian R; Higgins, Christopher F; Raguz, Selina.

Cancer Res; 67(3): 1130-7, 2007 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-17283147

19.

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

Nystrom, Maria L; McCulloch, Diana; Weinreb, Paul H; Violette, Shelia M; Speight, Paul M; Marshall, John F; Hart, Ian R; Thomas, Gareth J.

Cancer Res; 66(22): 10833-42, 2006 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-17108119

20.

Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis.

Parsons, Maddy; Keppler, Melanie D; Kline, Adam; Messent, Anthea; Humphries, Martin J; Gilchrist, Ruth; Hart, Ian R; Quittau-Prevostel, Corinne; Hughes, William E; Parker, Peter J; Ng, Tony.

Mol Cell Biol; 22(16): 5897-911, 2002 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-12138200

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