RESUMEN
PURPOSE: This trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group compares the use of high-dose therapy (HDT) as part of primary treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus etoposide followed by involved-field (IF) radiotherapy in a randomized, multicenter, phase III study. PATIENTS AND METHODS: Three hundred twelve patients with "aggressive" non-Hodgkin's lymphoma aged Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico
, L-Lactato Deshidrogenasa/sangre
, Linfoma no Hodgkin/enzimología
, Linfoma no Hodgkin/terapia
, Trasplante de Células Madre
, Protocolos de Quimioterapia Combinada Antineoplásica/administración & dosificación
, Carmustina/administración & dosificación
, Quimioterapia Adyuvante
, Ciclofosfamida/administración & dosificación
, Citarabina/administración & dosificación
, Doxorrubicina/administración & dosificación
, Esquema de Medicación
, Etopósido/administración & dosificación
, Femenino
, Alemania
, Humanos
, Linfoma no Hodgkin/tratamiento farmacológico
, Linfoma no Hodgkin/radioterapia
, Masculino
, Melfalán/administración & dosificación
, Persona de Mediana Edad
, Prednisolona/administración & dosificación
, Pronóstico
, Estudios Prospectivos
, Radioterapia Adyuvante
, Riesgo
, Análisis de Supervivencia
, Trasplante Autólogo
, Resultado del Tratamiento
, Vincristina/administración & dosificación
RESUMEN
Our in vitro data indicate that peripheral blood monocytes or monocyte-derived immature dendritic cells under appropriate culture conditions transdifferentiate into endothelial-like cells (ELC), which are characterized by the expression of endothelial markers and the formation of tube-like structures. Dependent on the culture conditions a mixed macrophage/endothelial or an endothelial phenotype could be induced. A similar pattern of development could be seen in CD14+ monocyte-derived ELC and ELC grown from CD34+ precursor cells or from dendritic cells generated from CD34+ cells. These in vitro data suggest that monocytes are precursors of different subgroups of endothelial cells and that the formation of endothelial cells from CD34+ progenitor cells follows a similar pathway possibly via the monocyte and/or the immature dendritic cell.