RESUMEN
Loeys-Dietz is a multisystem congenital syndrome that comprises craniofacial and cutaneous abnormalities as well as structural cardiac defects. One of its key pathological features is an aggressive widespread vasculopathy that can manifest as aortic or cerebral aneurysms, which is prone to dissection and rupture. We report a case of a large aneurysm of the ductus arteriosus in a patient with Loeys-Dietz syndrome, successfully occluded by interventional catheterization.
Asunto(s)
Aneurisma/diagnóstico por imagen , Aneurisma/terapia , Aortografía/métodos , Cateterismo Cardíaco , Conducto Arterial/diagnóstico por imagen , Cardiopatías/diagnóstico por imagen , Cardiopatías/terapia , Síndrome de Loeys-Dietz/complicaciones , Tomografía Computarizada por Rayos X , Aneurisma/complicaciones , Cateterismo Cardíaco/instrumentación , Cardiopatías/complicaciones , Humanos , Lactante , Síndrome de Loeys-Dietz/diagnóstico , Síndrome de Loeys-Dietz/genética , Masculino , Valor Predictivo de las Pruebas , Resultado del TratamientoRESUMEN
It has been suggested previously that rebound hypercoagulability may be responsible for morbidity and mortality following clopidogrel cessation in adults with acute coronary syndrome. We report a case of acute occlusion of a modified Blalock-Taussig shunt in an infant after clopidogrel discontinuation.
Asunto(s)
Anticoagulantes/efectos adversos , Procedimiento de Blalock-Taussing , Oclusión de Injerto Vascular/inducido químicamente , Síndrome de Abstinencia a Sustancias/etiología , Ticlopidina/análogos & derivados , Anticoagulantes/administración & dosificación , Anticoagulantes/uso terapéutico , Aspirina/administración & dosificación , Aspirina/uso terapéutico , Clopidogrel , Resultado Fatal , Oclusión de Injerto Vascular/cirugía , Oclusión de Injerto Vascular/terapia , Paro Cardíaco/etiología , Defectos del Tabique Interventricular/cirugía , Humanos , Hipoxia-Isquemia Encefálica/etiología , Recién Nacido , Masculino , Atresia Pulmonar/cirugía , Reoperación , Estado Epiléptico/etiología , Ticlopidina/administración & dosificación , Ticlopidina/efectos adversos , Ticlopidina/uso terapéutico , Atresia Tricúspide/cirugíaRESUMEN
Records of 11 cats with transitional cell carcinoma of the urinary bladder, which had been treated with meloxicam, were reviewed for signalment, duration of clinical signs prior to diagnosis, results of diagnostic imaging, whether or not concurrent surgery was performed and survival. Immunohistochemical expression of cyclo-oxygenase-1 (COX-1) and cyclo-oxygenase-2 (COX-2) was assessed in the tumours of seven cats. Tumour location varied greatly. The cats had a mean age of 13 years. Three cats had a previous diagnosis of feline idiopathic cystitis of up to 2008 days duration. Ten of the cats showed clinical improvement (reduction of haematuria and/or dysuria), with a mean survival time (MST) of 311 days (range 10-1064); 1-year survival of 50%. All seven bladders assessed for COX staining were COX-1 positive and five were COX-2 positive. The MST for the COX-2-positive cats was 123 days, the MST for the COX-2-negative cases was 375 days.