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1.

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.

Xiao, Yibei; Luo, Min; Hayes, Robert P; Kim, Jonathan; Ng, Sherwin; Ding, Fang; Liao, Maofu; Ke, Ailong.

Cell; 170(1): 48-60.e11, 2017 Jun 29.

Artículo en Inglés | MEDLINE | ID: mdl-28666122

2.

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

Hayes, Robert P; Xiao, Yibei; Ding, Fran; van Erp, Paul B G; Rajashankar, Kanagalaghatta; Bailey, Scott; Wiedenheft, Blake; Ke, Ailong.

Nature; 530(7591): 499-503, 2016 Feb 25.

Artículo en Inglés | MEDLINE | ID: mdl-26863189

3.

Catalytic mechanism of 5-chlorohydroxyhydroquinone dehydrochlorinase from the YCII superfamily of largely unknown function.

Hayes, Robert P; Lewis, Kevin M; Xun, Luying; Kang, ChulHee.

J Biol Chem; 288(40): 28447-56, 2013 Oct 04.

Artículo en Inglés | MEDLINE | ID: mdl-23955343

4.

Structural characterization of 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA) from Sphingobium chlorophenolicum, a new type of aromatic ring-cleavage enzyme.

Hayes, Robert P; Green, Abigail R; Nissen, Mark S; Lewis, Kevin M; Xun, Luying; Kang, Chulhee.

Mol Microbiol; 88(3): 523-36, 2013 May.

Artículo en Inglés | MEDLINE | ID: mdl-23489289

5.

Elucidation of the structure and reaction mechanism of sorghum hydroxycinnamoyltransferase and its structural relationship to other coenzyme a-dependent transferases and synthases.

Walker, Alexander M; Hayes, Robert P; Youn, Buhyun; Vermerris, Wilfred; Sattler, Scott E; Kang, ChulHee.

Plant Physiol; 162(2): 640-51, 2013 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-23624856

6.

Structures of the inducer-binding domain of pentachlorophenol-degrading gene regulator PcpR from Sphingobium chlorophenolicum.

Hayes, Robert P; Moural, Timothy W; Lewis, Kevin M; Onofrei, David; Xun, Luying; Kang, ChulHee.

Int J Mol Sci; 15(11): 20736-52, 2014 Nov 12.

Artículo en Inglés | MEDLINE | ID: mdl-25397598

7.

Structural understanding of the glutathione-dependent reduction mechanism of glutathionyl-hydroquinone reductases.

Green, Abigail R; Hayes, Robert P; Xun, Luying; Kang, ChulHee.

J Biol Chem; 287(43): 35838-48, 2012 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-22955277

8.

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia.

Layton, Mark E; Kern, Jeffrey C; Hartingh, Timothy J; Shipe, William D; Raheem, Izzat; Kandebo, Monika; Hayes, Robert P; Huszar, Sarah; Eddins, Donnie; Ma, Bennett; Fuerst, Joy; Wollenberg, Gordon K; Li, Jing; Fritzen, Jeff; McGaughey, Georgia B; Uslaner, Jason M; Smith, Sean M; Coleman, Paul J; Cox, Christopher D.

J Med Chem; 66(2): 1157-1171, 2023 01 26.

Artículo en Inglés | MEDLINE | ID: mdl-36624931

9.

Structural and catalytic differences between two FADH(2)-dependent monooxygenases: 2,4,5-TCP 4-monooxygenase (TftD) from Burkholderia cepacia AC1100 and 2,4,6-TCP 4-monooxygenase (TcpA) from Cupriavidus necator JMP134.

Hayes, Robert P; Webb, Brian N; Subramanian, Arun Kumar; Nissen, Mark; Popchock, Andrew; Xun, Luying; Kang, ChulHee.

Int J Mol Sci; 13(8): 9769-9784, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22949829

10.

Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.

Hayes, Robert P; Heo, Mee Ra; Mason, Mark; Reid, John; Burlein, Christine; Armacost, Kira A; Tellers, David M; Raheem, Izzat; Shaw, Anthony W; Murray, Edward; McKenna, Philip M; Abeywickrema, Pravien; Sharma, Sujata; Soisson, Stephen M; Klein, Daniel.

Nat Commun; 12(1): 3040, 2021 05 24.

Artículo en Inglés | MEDLINE | ID: mdl-34031403

11.

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Quiroz, Ryan V; Reutershan, Michael H; Schneider, Sebastian E; Sloman, David; Lacey, Brian M; Swalm, Brooke M; Yeung, Charles S; Gibeau, Craig; Spellman, Daniel S; Rankic, Danica A; Chen, Dapeng; Witter, David; Linn, Doug; Munsell, Erik; Feng, Guo; Xu, Haiyan; Hughes, Jonathan M E; Lim, Jongwon; Saurí, Josep; Geddes, Kristin; Wan, Murray; Mansueto, My Sam; Follmer, Nicole E; Fier, Patrick S; Siliphaivanh, Phieng; Daublain, Pierre; Palte, Rachel L; Hayes, Robert P; Lee, Sandra; Kawamura, Shuhei; Silverman, Steven; Sanyal, Sulagna; Henderson, Timothy J; Ye, Yingchun; Gao, Yuanwei; Nicholson, Benjamin; Machacek, Michelle R.

J Med Chem; 64(7): 3911-3939, 2021 04 08.

Artículo en Inglés | MEDLINE | ID: mdl-33755451

12.

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).

Palte, Rachel L; Schneider, Sebastian E; Altman, Michael D; Hayes, Robert P; Kawamura, Shuhei; Lacey, Brian M; Mansueto, My Sam; Reutershan, Michael; Siliphaivanh, Phieng; Sondey, Christopher; Xu, Haiyan; Xu, Zangwei; Ye, Yingchun; Machacek, Michelle R.

ACS Med Chem Lett; 11(9): 1688-1693, 2020 Sep 10.

Artículo en Inglés | MEDLINE | ID: mdl-32944135

13.

Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.

Sanchez, Emiliano J; Hayes, Robert P; Barr, John T; Lewis, Kevin M; Webb, Brian N; Subramanian, Arun K; Nissen, Mark S; Jones, Jeffrey P; Shelden, Eric A; Sorg, Barbara A; Fill, Michael; Schenk, James O; Kang, Chulhee.

Drug Alcohol Depend; 133(2): 344-51, 2013 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-23876860

14.

One more piece down to solve the III-A CRISPR puzzle.

Hayes, Robert P; Ke, Ailong.

J Mol Biol; 427(2): 228-30, 2015 Jan 30.

Artículo en Inglés | MEDLINE | ID: mdl-25451600

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