The effect of white grub (Maladera Verticalis) larvae feeding on rhizosphere microbial characterization of aerobic rice (Oryza sativa L.) in Puer City, Yunnan Province, China.

BACKGROUND: Rhizosphere microorganisms are vital in plants' growth and development and these beneficial microbes are recruited to the root-zone soil when experiencing various environmental stresses. However, the effect of white grub (Maladera verticalis) larvae feeding on the structure and function of rhizosphere microbial communities of aerobic rice (Oryza sativa L.) is unclear. RESULTS: In this study, we compared physicochemical properties, enzyme activities, and microbial communities using 18 samples under healthy and M. verticalis larvae-feeding aerobic rice rhizosphere soils at the Yunnan of China. 16 S rRNA and ITS amplicons were sequenced using Illumina high throughput sequencing. M. verticalis larvae feeding on aerobic rice can influence rhizosphere soil physicochemical properties and enzyme activities, which also change rhizosphere microbial communities. The healthy and M. verticalis larvae-feeding aerobic rice rhizosphere soil microorganisms had distinct genus signatures, such as possible_genus_04 and Knoellia genera in healthy aerobic rice rhizosphere soils and norank_f__SC - I-84 and norank_f__Roseiflexaceae genera in M. verticalis larvae-feeding aerobic rice rhizosphere soils. The pathway of the metabolism of terpenoids and polyketides and carbohydrate metabolism in rhizosphere bacteria were significantly decreased after M. verticalis larvae feeding. Fungal parasite-wood saprotroph and fungal parasites were significantly decreased after M. verticalis larvae feeding, and plant pathogen-wood saprotroph and animal pathogen-undefined saprotroph were increased after larvae feeding. Additionally, the relative abundance of Bradyrhizobium and Talaromyces genera gradually increased with the elevation of the larvae density. Bacterial and fungal communities significantly correlated with soil physicochemical properties and enzyme activities, respectively. CONCLUSIONS: Based on the results we provide new insight for understanding the adaptation of aerobic rice to M. verticalis larvae feeding via regulating the rhizosphere environment, which would allow us to facilitate translation to more effective measures.

Discovery and Potential Functional Characterization of Long Noncoding RNAs Associated with Familial Acne Inversa with NCSTN Mutation.

BACKGROUND: Long noncoding RNAs (lncRNAs) are associated with many dermatologic diseases. However, little is known about the regulatory function of lncRNAs in familial acne inversa (AI) patients with nicastrin (NCSTN) mutation. OBJECTIVES: The aim of this study was to explore the regulatory function of lncRNAs in familial AI patients with NCSTN mutation. METHODS: The expression profiles of lncRNAs and mRNAs in skin tissues from familial AI patients with NCSTN mutation and healthy individuals were analysed in this study via RNA sequencing (RNA-seq). RESULTS: In total, 359 lncRNAs and 1,863 mRNAs were differentially expressed between the two groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed that the dysregulated mRNAs targeted by lncRNAs were mainly associated with the immune regulation, Staphylococcus aureus infection and B cell receptor signalling pathways. The lncRNA-miRNA-mRNA coexpression network contained 265 network pairs comprising 55 dysregulated lncRNAs, 11 miRNAs, and 74 mRNAs. Conservation analysis of the differentially expressed lncRNAs between familial AI patients with NCSTN mutation and Ncstn keratinocyte-specific knockout (NcstnΔKC) mice identified 6 lncRNAs with sequence conservation; these lncRNAs may participate in apoptosis, proliferation, and skin barrier function. CONCLUSIONS: These findings provide a direction for exploring the regulatory mechanisms underlying the progression of familial AI patients with NCSTN mutation.

Mixed uncertainty analysis on pumping by peristaltic hearts using Dempster-Shafer theory.

In this paper, we introduce the numerical strategy for mixed uncertainty propagation based on probability and Dempster-Shafer theories, and apply it to the computational model of peristalsis in a heart-pumping system. Specifically, the stochastic uncertainty in the system is represented with random variables while epistemic uncertainty is represented using non-probabilistic uncertain variables with belief functions. The mixed uncertainty is propagated through the system, resulting in the uncertainty in the chosen quantities of interest (QoI, such as flow volume, cost of transport and work). With the introduced numerical method, the uncertainty in the statistics of QoIs will be represented using belief functions. With three representative probability distributions consistent with the belief structure, global sensitivity analysis has also been implemented to identify important uncertain factors and the results have been compared between different peristalsis models. To reduce the computational cost, physics constrained generalized polynomial chaos method is adopted to construct cheaper surrogates as approximations for the full simulation.

Longitudinal relationships among sociocultural pressure for body image, self-concept clarity, and emotional well-being in adolescents.

INTRODUCTION: This study examined the longitudinal relationships among sociocultural pressure for body image (SPBI), self-concept clarity (SCC), and emotional well-being (EWB) at both the between- and within-person levels. METHODS: The participants were 2001 Chinese adolescents (age range 11-24, 42.9% males). Recruitment of participants occurred for 1 year across three waves (i.e., 6 months apart across three cohorts). The baseline and follow-up questionnaire surveys were utilized to assess SPBI, SCC, EWB, and background variables. Longitudinal associations between the above main variables were tested using a cross-lagged panel model (CLPM) and multilevel regression analysis. RESULTS: The CLPM and multilevel-model analysis showed that SCC longitudinally mediated the relationships between SPBI and EWB. Besides, gender and age were considered moderators in the associations among SPBI, SCC, and EWB. CONCLUSIONS: SCC could be an underlying mechanism for the longitudinal relationship between SPBI and EWB among Chinese adolescents, which provides a potential intervention target for improving adolescents' well-being from a sociocultural framework.

4-Octyl itaconate promotes alveolar ridge preservation following tooth extraction.

The search for medications that can effectively reduce alveolar bone loss following tooth extraction is of great interest. This study aimed to observe the roles of 4-octyl itaconate (4-OI) in RANKL-induced osteoclastogenesis of bone marrow macrophages (BMMs) in vitro. Mandibular second molars were extracted to evaluate whether 4-OI could alleviate alveolar bone loss. 4-OI inhibited RANKL-induced osteoclastogenesis and promoted Nrf2 expression in bone marrow macrophages in vitro. Positive Nrf2 expressions were observed in inflammatory cells and osteoclasts in vivo. Treatment with 4-octyl itaconate increased Nrf2 expression, resulting in reduced inflammatory infiltration and osteoclastic activity after tooth extraction. Furthermore, increased expression of OCN and enhanced-alveolar bone healing of extraction socket were observed in the 4-OI group compared to the control group. Our results suggested that 4-OI could serve as a promising pharmacologic candidate for alveolar ridge preservation by alleviating alveolar bone loss following tooth extraction in rats.

Mediation of self-concept clarity and self-control between negative emotional states and emotional eating in Chinese adolescents.

Recent studies have consistently lent support for the significant relationship between negative emotional states (e.g., anxiety, stress, and depression) and emotional eating; however, only a handful of studies focused on examining the potential mediator in this association. The present study aimed to contribute to the literature surrounding the link between negative emotional states and emotional eating and to examine the mediating role of self-concept clarity and self-control in this association among a sample of Chinese adolescents (N = 1347, 62.44% girls). Results indicated that adolescents perceived higher levels of negative emotional states were linked to higher emotional eating. Additionally, the structural equation model suggested that symptoms of stress and depression could be associated with emotional eating through self-control. Moreover, the serial mediation effect of self-concept clarity and self-control could account for the association of negative emotional states (e.g., symptoms of anxiety, stress, and depression) and emotional eating. Overall, this study advances our understanding of the underlying mechanisms through which negative emotional states predict emotional eating in adolescence. If future studies reveal converging findings, this knowledge points to the need for programs preventing the development of emotional eating in adolescence through increasing the level of self-control and self-concept clarity.

Gastrointestinal disease is an important influencing factor of osteoporosis fracture:a retrospective study in chinese postmenopausal women.

BACKGROUD: The influencing factors of osteoporosis are complex, the incidence of osteoporosis is higher in middle-aged and elderly women, and osteoporotic fractures (OF) can seriously affect quality of life. Currently, the correlation analysis between gastrointestinal diseases and OF focuses more on diseases such as gastric cancer and inflammatory bowel disease (IBD). This study analyzed the risk factors for osteoporosis and osteoporotic fractures in 1567 postmenopausal women in Fuzhou, China. The purpose is to explore the potential influence of gastrointestinal diseases on the occurrence of OF. METHODS: According to inclusion and exclusion criteria, a total of 1567 subjects were included in the analysis of OP risk factors, including 647 in the OP group and 920 in the NOP group. A total of 616 subjects were included in the analysis of correlation between OF and gastrointestinal diseases, including 132 in OF group and 484 in NF group. Statistical analysis shows that age (OR = 1.062, 95% CI = 1.045-1.080), height (OR = 0.089, 95% CI = 0.009-0.857), weight (OR = 0.981,95% CI = 0.967-0.995) and nature of work (P = 0.010) are the main risk factors for osteoporosis in postmenopausal women in southeast China, and gastrointestinal diseases (OR = 1.583, 95% CI = 1.070-2.343) and height (OR = 0.003, 95% CI = 0.000-0.104) are the main risk factors of OF. CONCLUSIONS: The main factors affecting the occurrence of OP in postmenopausal women in southeast China are individual characteristic. Gastrointestinal diseases that do not directly affect BMD increase the risk of OF in osteoporotic patients.

Influence of Different Ratios of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus on Fermentation Characteristics of Yogurt.

Lactic acid bacteria (LAB) are industrially important bacteria that are widely used in the fermented food industry, especially in the manufacture of yogurt. The fermentation characteristics of LAB are an important factor affecting the physicochemical properties of yogurts. Here, different ratios of L. delbrueckii subsp. bulgaricus IMAU20312 and S. thermophilus IMAU80809 were compared with a commercial starter JD (control) for their effects on viable cell counts, pH values, titratable acidity (TA), viscosity and water holding capacity (WHC) of milk during fermentation. Sensory evaluation and flavour profiles were also determined at the end of fermentation. All samples had a viable cell count above 5.59 × 107 CFU/mL at the end of fermentation, and a significant increase in TA and decrease in pH were observed. Viscosity, WHC and the sensory evaluation results of one treatment ratio (A3) were closer to the commercial starter control than the others. A total of 63 volatile flavour compounds and 10 odour-active (OAVs) compounds were detected in all treatment ratios and the control according to the results from solid-phase micro-extraction-gas chromatography-mass spectrometry (SPME-GC-MS). Principal components analysis (PCA) also indicated that the flavour characteristics of the A3 treatment ratio were closer to the control. These results help us understand how the fermentation characteristics of yogurts are affected by the ratio of L. delbrueckii subsp. bulgaricus to S. thermophilus in starter cultures; this is useful for the development of value-added fermented dairy products.

Regulating Steric Hindrance in Redox-Active Porous Organic Frameworks Achieves Enhanced Sodium Storage Performance.

The development of novel redox-active polymers for sustainable sodium ion batteries (SIBs) has captured growing attention, but battery performance has been significantly limited by poor reversible specific capacities, where the majority of aromatic C6-benzene linkages are redox inactive. Here, a simple, yet efficient approach to improve sodium (Na) storage on these C6-benzene rings within a porous polymeric framework by rationally regulating their steric hindrance is reported. Decreasing intrinsic hindrance affords a significant improvement in redox reaction kinetics within the porous architecture, thereby facilitating the acceptance of Na ions on these functionalized benzene rings and boosting the SIB performance. As a result, the modulate porous framework exhibits an exceptional battery capacity of 376 mAh g-1 after 1000 cycles at 1.0 A g-1 , which is ≈1.5 times larger than that of the pristine framework. Furthermore, the performance can reach as high as 510 mAh g-1 at 0.1 A g-1 , comparable to that of the best-performing polymeric electrodes. The simple modulation approach not only enables Na storage modulation on functionalized C6-benzene rings, but also simultaneously provides a means to extend the understanding of the structure-property relationship and facilitate new possibilities for organic SIBs.

Distant metastasis without regional progression in non-muscle invasive bladder cancer: case report and pooled analysis of literature.

BACKGROUND: Non-muscle invasive bladder cancer (NMIBC) represents the majority of bladder neoplasms. It is unusual for NMIBC metastasizing distantly without regional progression, namely metastatic NMIBC (mNMIBC), which is still poorly understood and easily omitted based on current management policies. So far, description of mNMIBC is limited to a few case reports. METHODS: We reported a 70-year-old man with NMIBC who suffered from cervical metastasis without pelvic recurrence at 41 months after initial diagnosis. Then we performed a collective analysis of this case together with published mNMIBC cases searched from PubMed, Embase, and Web of Science, aiming to illustrate baseline clinicopathologic parameters, metastatic patterns, and treatment outcomes of these patients and analyze associated influencing factors. RESULTS: After scrupulous review, 45 cases previous reported and the one from our center were incorporated into the aggregated cohort of mNMIBC, including 34 males and 12 females. Primary tumors from 46.7% of patients were high-grade (HG) or grade 3 (G3) and 65.1% had T1 lesions. Aberrant biomarker expression was found in tumors of some cases. Most (40/46) metastases of mNMIBC occurred at a single site, mainly in lung, bone and lymph nodes. Apart from three cases of de novo mNMIBC, the mean metastasis-free survival (MFS) interval of metachronous mNMIBC was 42.5 months, which was obviously longer than conventional metastatic bladder cancer. Shortened MFS interval was associated with old age, T1 or HG/G3 primary tumors, and non-lung metastases. Systemic chemotherapy and metastasectomy or radiotherapy for oligometastatic lesion were main therapeutic approaches of mNMIBC, and immunotherapy was adopted for the case from our center. Lung and bone metastases correlated with relatively favorable and unfavorable survival outcomes, respectively. Compared with monotherapy, chemotherapy, or immunotherapy combined with local cytoreduction got more favorable outcomes. CONCLUSION: Although rare, mNMIBC occurs more in tumors with high-risk features. Usually, mNMIBC metastasizes later than conventional metastatic bladder cancer and manifests as solitary lesion. Outcomes of mNMIBC would be influenced by metastatic site and post-metastatic treatment. Systemic treatment combined with local cytoreduction may render survival benefit in selected patients.

The biological and chemical contents of atmospheric particulate matter and implication of its role in the transmission of bacterial pathogenesis.

Atmospheric particulate matter (APM) is an environmental hazard that endangers human health and causes a variety of diseases. In this work, the microbial community composition, chemical element composition and antimicrobial resistance gene (ARG) prevalence, along with their relationships with environmental parameters were analysed using APM samples collected in Jinan, China. Pathogenic Klebsiella and Aeromonas were found to be significantly correlated with PM2.5 and temperature, suggesting their proliferation on APM. PM2.5 and PM10 have similar microbial community compositions but different chemical element compositions, suggesting they have different origins, which have little impact on microbial community structures. This finding, together with analysis of the timing of microbial community structure changes, suggests that microbial community composition is impacted by anthropic activities. Further investigations showed that rare metals including lanthanides are significantly negatively correlated with pathogens in APM, suggesting their inhibitory role. ARGs were observed for every class of antibiotic except for carbapenems in APM, suggesting high ARG prevalence in APM, and APM functions in transmission of antimicrobial resistance. Results obtained in this study suggest that APM can act as a transmission vehicle for pathogenic bacteria and ARGs and lead to the implication of a new transmission route for bacterial pathogenesis by APM.

Gene expression profile and long noncoding RNA analysis in Candida albicans insoluble ß-glucan-stimulated CD14+ monocytes and THP-1 cells.

Emerging evidence suggests that long noncoding RNAs (lncRNAs) play important roles in disease development. However, the roles of lncRNAs in the pathogenesis of Candida albicans (C. albicans) remain unclear. Our study aimed to investigate and characterize the mRNA and lncRNA transcriptomes of CD14+ monocytes and THP-1 cells stimulated with insoluble ß-glucan by RNA-seq. We identified a total of 10788 differentially expressed (DE) mRNAs and 2021 DE lncRNAs in CD14+ monocytes, while 3349 DE mRNAs and 291 DE lncRNAs were observed in THP-1 cells. A total of 808 DE mRNAs and 51 DE lncRNAs overlapped between the two groups. We examined five collectively DE mRNAs and lncRNAs in both cells using quantitative real-time PCR, validating the reliability of the RNA-seq results. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that the 808 DE mRNAs were mostly enriched in the inflammatory response and NF-kappa B signaling pathway, respectively. Next, lncRNA-mRNA coexpression analysis was performed for the 51 DE lncRNAs and the 808 DE mRNAs in the two groups. We chose the common network pairs of the two groups to construct the coexpression network and revealed 97 network pairs comprising 8 dysregulated lncRNAs and 60 dysregulated mRNAs. We found that lncRNA lnc-CCL3L3-1:1 might be involved in the NF-kappa B signaling pathway in C. albicans infection. In conclusion, the aberrantly expressed lncRNAs might play a role in the pathogenesis of C. albicans infection and could be used as therapeutic targets in the future.

Flat-Band Localization in Creutz Superradiance Lattices.

Flat bands play an important role in diffraction-free photonics and attract fundamental interest in many-body physics. Here we report the engineering of flat-band localization of collective excited states of atoms in Creutz superradiance lattices with tunable synthetic gauge fields. Magnitudes and phases of the lattice hopping coefficients can be independently tuned to control the state components of the flat band and the Aharonov-Bohm phases. We can selectively excite the flat band and control the flat-band localization with the synthetic gauge field. Our study provides a room-temperature platform for flat bands of atoms and holds promising applications in exploring correlated topological materials.

Norisoboldine Attenuates Sepsis-Induced Acute Lung Injury by Modulating Macrophage Polarization via PKM2/HIF-1α/PGC-1α Pathway.

This study aimed to investigate the effect of norisopoldine (NOR) on acute lung injury in septic mice. Lipopolysaccharide (LPS) was used to establish sepsis induced acute lung injury (ALI) in mice. The dry and wet weight of mice lung was detected, and the pathological changes of lung were observed by hematoxylin and eosin (H&E) staining. Bronchoalveolar lavage fluid (BALF) was detected. Inflammatory factors in BALF were detected by enzyme-linked immunosorbent assay (ELISA). The polarization of macrophages in lung tissue was detected by flow cytometry. The markers of M1 and M2 macrophages were detected by RT-PCR. LPS induced RAW264.7 cells were treated with NOR. Inflammatory response, macrophage polarization, glycolysis, and M2 pyruvate kinase (PKM2)/hypoxia inducible factor-1α (HIF-1α)/peroxisome proliferator activated receptor-γ co-activator 1-α (PGC-1α) signaling pathway were detected. NOR could effectively alleviate sepsis induced ALI, and reduce the number of total cells, total protein concentration, neutrophils, macrophages in BALF. NOR decreased the level of inflammatory factors and promoted macrophages from M1 to M2 type in vivo and vitro. Moreover, NOR could activated PKM2, and inhibited PKM2 from cytoplasm to nuclear, attenuated HIF-1α expression, and increased PGC-1α and peroxisome proliferator-activated receptor (PPAR)-γ expression. In addition, NOR inhibited glycolysis and promoted oxidative phosphorylation in RAW264.7 cells. Furthermore, PKM2 inhibitors could reverse the effect of NOR on PKM2/HIF-1α/PGC-1α signaling pathway in RAW264.7 cells. NOR alleviated sepsis induced AIL in mice, inhibited the inflammatory response, promote M2 polarization of macrophages through regulating PKM2/HIF-1α/PGC-1α signaling pathway.

Analysis of the antennal transcriptome and odorant-binding protein expression profiles of the parasitoid wasp Encarsia formosa.

The parasitoid of whiteflies Encarsia formosa has been widely applied to reduce whitefly-mediated damage on vegetables and ornamental plants grown in greenhouses. Although its chemosensory behavior has been described, the mechanism by which E. formosa recognizes chemical volatiles at the molecular level remains unknown. In this study, we obtained 66,632 unigenes from antennae transcriptomic architecture of E. formosa, of which 19,473 (29.2%) were functionally annotated. All that matters is that we manually identified 39 odorant-binding proteins (OBPs) from above dataset, and further investigated the tissue and stage-specific expression profiles of all identified OBP genes by real-time quantitative PCR. Among these OBP genes, 32 were enriched in antennae, and 2 in body. In addition, 4 OBPs were highly expressed in pupae, and 32 in 6-hour-age adults after eclosion. In addition to identifying OBP genes from E. formosa, this study provides a molecular basis for further functional studies of OBPs and the interactions of hosts and parasitic wasps.

A clinical study to assess the gingivitis reduction efficacy of a novel stannous-containing fluoride dentifrice.

PURPOSE: To assess the gingivitis reduction efficacy of a novel stannous-containing fluoride dentifrice relative to a negative control. METHODS: 100 generally healthy adults with 10 or more gingival bleeding sites based on the Mazza Modification of the Papillary Bleeding Index (Mazza GI) were enrolled into a 2-week randomized, controlled, double-blind, single-center, two-treatment, parallel group clinical study. The subjects were randomly assigned to the stannous-containing dentifrice group (experimental group) or the sodium fluoride dentifrice group (negative control group). An oral examination and Mazza GI examination were conducted at Baseline, Day 3 and Week 2 post-baseline by a qualified dental examiner. RESULTS: 98 subjects completed the study. The experimental group provided a significant reduction in Mazza GI scores and number of bleeding sites relative to baseline at Day 3 and Week 2 (P< 0.0001). The negative control did not provide significant reductions versus baseline for either measure at either timepoint (P> 0.3). At Day 3, the experimental group provided a statistically significant reduction of Mazza GI scores and number of bleeding sites compared with the negative control group (P< 0.0001). At Week 2, the experimental group showed 24.11% lower Mazza GI scores and 54.81% fewer bleeding sites than the negative control group (P< 0.0001). CLINICAL SIGNIFICANCE: The results demonstrated that the novel stannous-containing fluoride dentifrice had a superior anti-gingivitis effect compared to the sodium fluoride negative control dentifrice, which was evident as quickly as 3 days after use and further improved after 2 weeks of usage.

Willow-Leaf-Like ZnSe@N-Doped Carbon Nanoarchitecture as a Stable and High-Performance Anode Material for Sodium-Ion and Potassium-Ion Batteries.

ZnSe is regarded as a promising anode material for energy storage due to its high theoretical capacity and environment friendliness. Nevertheless, it is still a significant challenge to obtain superior electrode materials with stable performance owing to the serious volume change and aggregation upon cycling. Herein, a willow-leaf-like nitrogen-doped carbon-coated ZnSe (ZnSe@NC) composite synthesized through facile solvothermal and subsequent selenization process is beneficial to expose more active sites and facilitate the fast electron/ion transmission. These merits significantly enhance the electrochemical performances of ZnSe@NC for sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs). The obtained ZnSe@NC exhibits outstanding rate performance (440.3 mAh g-1 at 0.1 A g-1 and 144.4 mAh g-1 at 10 A g-1 ) and ultralong cycle stability (242.2 mAh g-1 at 8.0 A g-1 even after 3200 cycles) for SIBs. It is noted that 106.5 mAh g-1 can be retained after 550 cycles and 71.4 mAh g-1 is still remained after 1500 cycles at 200 mA g-1 when applied as anode for PIBs, indicating good cycle stability of the electrode. The possible electrochemical mechanism and the ionic diffusion kinetics of the ZnSe@NC are investigated using ex situ X-ray diffraction, high-resolution transmission electron microscopy, and a series of electrochemical analyses.

Observation of the interplay between seeded and self-seeded nondegenerate four-wave mixing in cesium vapor.

Nondegenerate four-wave mixing (NFWM) is a practical and effective technique for generating or amplifying light fields at different wavelengths, and could be used to create color correlation and entanglement. Here we experimentally investigate the NFWM process in diamond atomic system via two-photon excitation with two pumps at 852 nm and 921 nm, demonstrating that a seeded NFWM with a third laser at 895 nm and two self-seeded NFWMs due to amplified spontaneous emission (ASE) occur simultaneously. We compare the two kinds of processes and show that the single- and two-photon detunings hold the key role in distinguishing them. As a result, the enhancement of seeded NFWM is obtained by selecting large one- and two-photon detunings, in which case the ASE induced self-seeded NFWM can be largely suppressed. In contrast, the ASE and its induced NFWM are effectively achieved with one- and two-photon resonant excitations allowing for population inversion for efficient ASE.

Experimental Observation of Momentum-Space Chiral Edge Currents in Room-Temperature Atoms.

Chiral edge currents play an important role in characterizing topological matter. In atoms, they have been observed at such a low temperature that the atomic motion can be measured. Here we report the first experimental observation of chiral edge currents in atoms at room temperature. Staggered magnetic fluxes are induced by the spatial phase difference between two standing-wave light fields, which couple atoms to form a momentum-space zigzag superradiance lattice. The chiral edge currents are measured by comparing the directional superradiant emissions of two timed Dicke states in the lattice. Our results pave the way for simulating topological physics in hot atoms.

[Clinical features and TTC21B genotype of a child with nephronophthisis type 12].

Nephronophthisis (NPHP) is a group of autosomal recessive tubulointerstitial cystic kidney disorders. This article reports a case of NPHP type 12 caused by TTC21B mutations. The girl had an insidious onset, with moderate proteinuria, renal dysfunction, stage 2 hypertension, situs inversus, and short phalanges when she visited the hospital for the first time at the age of 3 years and 6 months. The renal lesions progressed to end-stage renal disease (ESRD) before she was 4 years old. Urine protein electrophoresis showed glomerular proteinuria. There were significant increases in urinary ß2-microglobulin and α1-microglobulin. Gene detection revealed two compound heterozygous mutations, c.1552T>C (p.C518R) and c.752T>G (p.M251R), in the TTC21B gene, which came from her father and mother respectively. The c.752T>G mutation was a novel mutation. It is concluded that besides typical tubular changes of NPHP, marked glomerular damage is also observed in patients with TTC21B gene mutations.