Detalles de la búsqueda
1.
Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells.
Nucleic Acids Res;
52(4): 1736-1752, 2024 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38109306
2.
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.
Clin Cancer Res;
29(8): 1631-1642, 2023 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36689546
3.
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J Med Chem;
65(20): 13879-13891, 2022 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36200480
4.
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
J Med Chem;
65(24): 16589-16621, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36455032
5.
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Nat Commun;
12(1): 3636, 2021 06 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34140467
6.
5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett;
19(6): 1658-61, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19231183
7.
Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents.
J Med Chem;
51(4): 963-75, 2008 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18247546
8.
Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".
J Med Chem;
2023 Feb 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36815444
9.
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.
ACS Med Chem Lett;
8(9): 936-940, 2017 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-28947940
10.
The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
J Med Chem;
59(3): 985-1002, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26741947
11.
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.
J Med Chem;
59(19): 9080-9093, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27564586
12.
Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat.
J Mol Biol;
334(1): 25-36, 2003 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-14596797
13.
Antitumor polycyclic acridines. 17. Synthesis and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity.
J Med Chem;
48(23): 7198-207, 2005 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-16279778
14.
Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.
J Med Chem;
48(8): 2993-3004, 2005 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15828838
15.
Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.
J Med Chem;
45(3): 590-7, 2002 Jan 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-11806711
16.
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
J Med Chem;
57(23): 10176-91, 2014 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-25383627
17.
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a ß-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.
J Med Chem;
56(11): 4597-610, 2013 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-23662903
18.
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
J Med Chem;
55(10): 4594-604, 2012 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-22506516
19.
Recognition and Stabilization of Quadruplex DNA by a Potent New Telomerase Inhibitor: NMR Studies of the 2:1 Complex of a Pentacyclic Methylacridinium Cation with d(TTAGGGT)(4) We thank the EPSRC of the UK and AstraZeneca for financial support to E.G. M.F.G.S. and R.A.H. are supported by the Cancer Research Campaign of the UK.
Angew Chem Int Ed Engl;
40(24): 4749-4751, 2001 Dec 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-12404405
20.
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Bioorg Med Chem Lett;
17(2): 363-9, 2007 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17107790