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1.

Top 10 Challenges in Cancer Immunotherapy.

Hegde, Priti S; Chen, Daniel S.

Immunity; 52(1): 17-35, 2020 01 14.

Artículo en Inglés | MEDLINE | ID: mdl-31940268

2.

TGFß attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Mariathasan, Sanjeev; Turley, Shannon J; Nickles, Dorothee; Castiglioni, Alessandra; Yuen, Kobe; Wang, Yulei; Kadel, Edward E; Koeppen, Hartmut; Astarita, Jillian L; Cubas, Rafael; Jhunjhunwala, Suchit; Banchereau, Romain; Yang, Yagai; Guan, Yinghui; Chalouni, Cecile; Ziai, James; Senbabaoglu, Yasin; Santoro, Stephen; Sheinson, Daniel; Hung, Jeffrey; Giltnane, Jennifer M; Pierce, Andrew A; Mesh, Kathryn; Lianoglou, Steve; Riegler, Johannes; Carano, Richard A D; Eriksson, Pontus; Höglund, Mattias; Somarriba, Loan; Halligan, Daniel L; van der Heijden, Michiel S; Loriot, Yohann; Rosenberg, Jonathan E; Fong, Lawrence; Mellman, Ira; Chen, Daniel S; Green, Marjorie; Derleth, Christina; Fine, Gregg D; Hegde, Priti S; Bourgon, Richard; Powles, Thomas.

Nature; 554(7693): 544-548, 2018 02 22.

Artículo en Inglés | MEDLINE | ID: mdl-29443960

3.

Association of CD274 (PD-L1) Copy Number Changes with Immune Checkpoint Inhibitor Clinical Benefit in Non-Squamous Non-Small Cell Lung Cancer.

Murugesan, Karthikeyan; Jin, Dexter X; Comment, Leah A; Fabrizio, David; Hegde, Priti S; Elvin, Julia A; Alexander, Brian; Levy, Mia A; Frampton, Garrett M; Montesion, Meagan; Roychowdhury, Sameek; Kurzrock, Razelle; Ross, Jeffrey S; Albacker, Lee A; Huang, Richard S P.

Oncologist; 27(9): 732-739, 2022 09 02.

Artículo en Inglés | MEDLINE | ID: mdl-35598202

4.

A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases.

Huang, Richard S P; Haberberger, James; Severson, Eric; Duncan, Daniel L; Hemmerich, Amanda; Edgerly, Claire; Ferguson, Naomi Lynn; Williams, Erik; Elvin, Julia; Vergilio, Jo-Anne; Killian, Jonathan Keith; Lin, Douglas I; Tse, Julie; Hiemenz, Matthew; Owens, Clarence; Danziger, Natalie; Hegde, Priti S; Venstrom, Jeffrey; Alexander, Brian; Ross, Jeffrey S; Ramkissoon, Shakti H.

Mod Pathol; 34(2): 252-263, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-32884129

5.

Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1).

Kowanetz, Marcin; Zou, Wei; Gettinger, Scott N; Koeppen, Hartmut; Kockx, Mark; Schmid, Peter; Kadel, Edward E; Wistuba, Ignacio; Chaft, Jamie; Rizvi, Naiyer A; Spigel, David R; Spira, Alexander; Hirsch, Fred R; Cohen, Victor; Smith, Dustin; Boyd, Zach; Miley, Natasha; Flynn, Susan; Leveque, Vincent; Shames, David S; Ballinger, Marcus; Mocci, Simonetta; Shankar, Geetha; Funke, Roel; Hampton, Garret; Sandler, Alan; Amler, Lukas; Mellman, Ira; Chen, Daniel S; Hegde, Priti S.

Proc Natl Acad Sci U S A; 115(43): E10119-E10126, 2018 10 23.

Artículo en Inglés | MEDLINE | ID: mdl-30297397

6.

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer.

Powles, Thomas; Eder, Joseph Paul; Fine, Gregg D; Braiteh, Fadi S; Loriot, Yohann; Cruz, Cristina; Bellmunt, Joaquim; Burris, Howard A; Petrylak, Daniel P; Teng, Siew-leng; Shen, Xiaodong; Boyd, Zachary; Hegde, Priti S; Chen, Daniel S; Vogelzang, Nicholas J.

Nature; 515(7528): 558-62, 2014 Nov 27.

Artículo en Inglés | MEDLINE | ID: mdl-25428503

7.

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients.

Herbst, Roy S; Soria, Jean-Charles; Kowanetz, Marcin; Fine, Gregg D; Hamid, Omid; Gordon, Michael S; Sosman, Jeffery A; McDermott, David F; Powderly, John D; Gettinger, Scott N; Kohrt, Holbrook E K; Horn, Leora; Lawrence, Donald P; Rost, Sandra; Leabman, Maya; Xiao, Yuanyuan; Mokatrin, Ahmad; Koeppen, Hartmut; Hegde, Priti S; Mellman, Ira; Chen, Daniel S; Hodi, F Stephen.

Nature; 515(7528): 563-7, 2014 Nov 27.

Artículo en Inglés | MEDLINE | ID: mdl-25428504

8.

Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics.

Hegde, Priti S; Wallin, Jeffrey J; Mancao, Christoph.

Semin Cancer Biol; 52(Pt 2): 117-124, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-29229461

9.

Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial.

Powles, Thomas; Durán, Ignacio; van der Heijden, Michiel S; Loriot, Yohann; Vogelzang, Nicholas J; De Giorgi, Ugo; Oudard, Stéphane; Retz, Margitta M; Castellano, Daniel; Bamias, Aristotelis; Fléchon, Aude; Gravis, Gwenaëlle; Hussain, Syed; Takano, Toshimi; Leng, Ning; Kadel, Edward E; Banchereau, Romain; Hegde, Priti S; Mariathasan, Sanjeev; Cui, Na; Shen, Xiaodong; Derleth, Christina L; Green, Marjorie C; Ravaud, Alain.

Lancet; 391(10122): 748-757, 2018 02 24.

Artículo en Inglés | MEDLINE | ID: mdl-29268948

10.

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.

Balar, Arjun V; Galsky, Matthew D; Rosenberg, Jonathan E; Powles, Thomas; Petrylak, Daniel P; Bellmunt, Joaquim; Loriot, Yohann; Necchi, Andrea; Hoffman-Censits, Jean; Perez-Gracia, Jose Luis; Dawson, Nancy A; van der Heijden, Michiel S; Dreicer, Robert; Srinivas, Sandy; Retz, Margitta M; Joseph, Richard W; Drakaki, Alexandra; Vaishampayan, Ulka N; Sridhar, Srikala S; Quinn, David I; Durán, Ignacio; Shaffer, David R; Eigl, Bernhard J; Grivas, Petros D; Yu, Evan Y; Li, Shi; Kadel, Edward E; Boyd, Zachary; Bourgon, Richard; Hegde, Priti S; Mariathasan, Sanjeev; Thåström, AnnChristine; Abidoye, Oyewale O; Fine, Gregg D; Bajorin, Dean F.

Lancet; 389(10064): 67-76, 2017 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-27939400

11.

Analytical validation of a novel comprehensive genomic profiling informed circulating tumor DNA monitoring assay for solid tumors.

Zollinger, Daniel R; Rivers, Elizabeth; Fine, Alexander; Huang, Yanmei; Son, Joseph; Kalyan, Akshita; Gray, Wren; Baharian, Golshid; Hammond, Carly; Ram, Rosalyn; Ringman, Lindsay; Hafez, Dina; Savel, Daniel; Patel, Vipul; Dantone, Marc; Guo, Cui; Childress, Merrida; Xu, Chang; Johng, Dorhyun; Wallden, Brett; Pokharel, Prapti; Camara, William; Hegde, Priti S; Hughes, Jason; Carter, Corey; Davarpanah, Nicole; Degaonkar, Viraj; Gupta, Pratyush; Mariathasan, Sanjeev; Powles, Thomas; Ferree, Sean; Dennis, Lucas; Young, Amanda.

PLoS One; 19(5): e0302129, 2024.

Artículo en Inglés | MEDLINE | ID: mdl-38753705

12.

Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation.

Sivakumar, Smruthy; Moore, Jay A; Montesion, Meagan; Sharaf, Radwa; Lin, Douglas I; Colón, Caterina I; Fleishmann, Zoe; Ebot, Ericka M; Newberg, Justin Y; Mills, Jennifer M; Hegde, Priti S; Pan, Quintin; Dowlati, Afshin; Frampton, Garrett M; Sage, Julien; Lovly, Christine M.

Cancer Discov; 13(7): 1572-1591, 2023 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-37062002

13.

Predicting EGFR mutational status from pathology images using a real-world dataset.

Pao, James J; Biggs, Mikayla; Duncan, Daniel; Lin, Douglas I; Davis, Richard; Huang, Richard S P; Ferguson, Donna; Janovitz, Tyler; Hiemenz, Matthew C; Eddy, Nathanial R; Lehnert, Erik; Cabili, Moran N; Frampton, Garrett M; Hegde, Priti S; Albacker, Lee A.

Sci Rep; 13(1): 4404, 2023 03 16.

Artículo en Inglés | MEDLINE | ID: mdl-36927889

14.

Molecular residual disease detection in resected, muscle-invasive urothelial cancer with a tissue-based comprehensive genomic profiling-informed personalized monitoring assay.

Powles, Thomas; Young, Amanda; Nimeiri, Halla; Madison, Russell W; Fine, Alexander; Zollinger, Daniel R; Huang, Yanmei; Xu, Chang; Gjoerup, Ole V; Aushev, Vasily N; Wu, Hsin-Ta; Aleshin, Alexey; Carter, Corey; Davarpanah, Nicole; Degaonkar, Viraj; Gupta, Pratyush; Mariathasan, Sanjeev; Schleifman, Erica; Assaf, Zoe June; Oxnard, Geoffrey; Hegde, Priti S.

Front Oncol; 13: 1221718, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-37601688

15.

Pan-Cancer Analysis of Copy-Number Features Identifies Recurrent Signatures and a Homologous Recombination Deficiency Biomarker to Predict Poly (ADP-Ribose) Polymerase Inhibitor Response.

Moore, Jay A; Chen, Kuei-Ting; Madison, Russell; Newberg, Justin Y; Fleischmann, Zoe; Wang, Shuoguo; Sharaf, Radwa; Murugesan, Karthikeyan; Fendler, Bernard J; Hughes, Jason; Schrock, Alexa B; Hegde, Priti S; Oxnard, Geoffrey R; Fabrizio, David; Frampton, Garrett M; Antonarakis, Emmanuel S; Sokol, Ethan S; Jin, Dexter X.

JCO Precis Oncol; 7: e2300093, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37769224

16.

CD8⁺ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.

Huseni, Mahrukh A; Wang, Lifen; Klementowicz, Joanna E; Yuen, Kobe; Breart, Beatrice; Orr, Christine; Liu, Li-Fen; Li, Yijin; Gupta, Vinita; Li, Congfen; Rishipathak, Deepali; Peng, Jing; SenbabaoÇ§lu, Yasin; Modrusan, Zora; Keerthivasan, Shilpa; Madireddi, Shravan; Chen, Ying-Jiun; Fraser, Eleanor J; Leng, Ning; Hamidi, Habib; Koeppen, Hartmut; Ziai, James; Hashimoto, Kenji; Fassò, Marcella; Williams, Patrick; McDermott, David F; Rosenberg, Jonathan E; Powles, Thomas; Emens, Leisha A; Hegde, Priti S; Mellman, Ira; Turley, Shannon J; Wilson, Mark S; Mariathasan, Sanjeev; Molinero, Luciana; Merchant, Mark; West, Nathaniel R.

Cell Rep Med; 4(1): 100878, 2023 01 17.

Artículo en Inglés | MEDLINE | ID: mdl-36599350

17.

Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Sivakumar, Smruthy; Jin, Dexter X; Tukachinsky, Hanna; Murugesan, Karthikeyan; McGregor, Kimberly; Danziger, Natalie; Pavlick, Dean; Gjoerup, Ole; Ross, Jeffrey S; Harmon, Robert; Chung, Jon; Decker, Brennan; Dennis, Lucas; Frampton, Garrett M; Molinero, Luciana; Oesterreich, Steffi; Venstrom, Jeffrey M; Oxnard, Geoffrey R; Hegde, Priti S; Sokol, Ethan S.

Nat Commun; 13(1): 7495, 2022 12 05.

Artículo en Inglés | MEDLINE | ID: mdl-36470901

18.

Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors.

Lee, Jessica K; Sivakumar, Smruthy; Schrock, Alexa B; Madison, Russell; Fabrizio, David; Gjoerup, Ole; Ross, Jeffrey S; Frampton, Garrett M; Napalkov, Pavel; Montesion, Meagan; Schutzman, Jennifer L; Ye, Xin; Hegde, Priti S; Nagasaka, Misako; Oxnard, Geoffrey R; Sokol, Ethan S; Ou, Sai-Hong Ignatius; Shi, Zhen.

NPJ Precis Oncol; 6(1): 91, 2022 Dec 09.

Artículo en Inglés | MEDLINE | ID: mdl-36494601

19.

C-reactive protein reduction post treatment is associated with improved survival in atezolizumab (anti-PD-L1) treated non-small cell lung cancer patients.

Patil, Namrata S; Zou, Wei; Mocci, Simonetta; Sandler, Alan; Ballinger, Marcus; Flynn, Susan; Kowanetz, Marcin; Hegde, Priti S.

PLoS One; 16(2): e0246486, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-33534859

20.

Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response.

Montesion, Meagan; Murugesan, Karthikeyan; Jin, Dexter X; Sharaf, Radwa; Sanchez, Nora; Guria, Ameet; Minker, Max; Li, Gerald; Fisher, Virginia; Sokol, Ethan S; Pavlick, Dean C; Moore, Jay A; Braly, Alan; Singal, Gaurav; Fabrizio, David; Comment, Leah A; Rizvi, Naiyer A; Alexander, Brian M; Frampton, Garrett M; Hegde, Priti S; Albacker, Lee A.

Cancer Discov; 11(2): 282-292, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33127846

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