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1.

Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study.

Campochiaro, Peter A; Avery, Robert; Brown, David M; Heier, Jeffrey S; Ho, Allen C; Huddleston, Stephen M; Jaffe, Glenn J; Khanani, Arshad M; Pakola, Stephen; Pieramici, Dante J; Wykoff, Charles C; Van Everen, Sherri.

Lancet; 403(10436): 1563-1573, 2024 Apr 20.

Artículo en Inglés | MEDLINE | ID: mdl-38554726

2.

Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 trial.

Lanzetta, Paolo; Korobelnik, Jean-François; Heier, Jeffrey S; Leal, Sergio; Holz, Frank G; Clark, W Lloyd; Eichenbaum, David; Iida, Tomohiro; Xiaodong, Sun; Berliner, Alyson J; Schulze, Andrea; Schmelter, Thomas; Schmidt-Ott, Ursula; Zhang, Xin; Vitti, Robert; Chu, Karen W; Reed, Kimberly; Rao, Rohini; Bhore, Rafia; Cheng, Yenchieh; Sun, Wei; Hirshberg, Boaz; Yancopoulos, George D; Wong, Tien Y.

Lancet; 403(10432): 1141-1152, 2024 Mar 23.

Artículo en Inglés | MEDLINE | ID: mdl-38461841

3.

Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial.

Khanani, Arshad M; Patel, Sunil S; Staurenghi, Giovanni; Tadayoni, Ramin; Danzig, Carl J; Eichenbaum, David A; Hsu, Jason; Wykoff, Charles C; Heier, Jeffrey S; Lally, David R; Monés, Jordi; Nielsen, Jared S; Sheth, Veeral S; Kaiser, Peter K; Clark, Julie; Zhu, Liansheng; Patel, Hersh; Tang, Justin; Desai, Dhaval; Jaffe, Glenn J.

Lancet; 402(10411): 1449-1458, 2023 Oct 21.

Artículo en Inglés | MEDLINE | ID: mdl-37696275

4.

Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials.

Heier, Jeffrey S; Lad, Eleonora M; Holz, Frank G; Rosenfeld, Philip J; Guymer, Robyn H; Boyer, David; Grossi, Federico; Baumal, Caroline R; Korobelnik, Jean-Francois; Slakter, Jason S; Waheed, Nadia K; Metlapally, Ravi; Pearce, Ian; Steinle, Nathan; Francone, Anibal A; Hu, Allen; Lally, David R; Deschatelets, Pascal; Francois, Cedric; Bliss, Caleb; Staurenghi, Giovanni; Monés, Jordi; Singh, Rishi P; Ribeiro, Ramiro; Wykoff, Charles C.

Lancet; 402(10411): 1434-1448, 2023 10 21.

Artículo en Inglés | MEDLINE | ID: mdl-37865470

5.

Ocular Effects of MEK Inhibitor Therapy: Literature Review, Clinical Presentation, and Best Practices for Mitigation.

Jeng-Miller, Karen W; Miller, Miles A; Heier, Jeffrey S.

Oncologist; 29(5): e616-e621, 2024 May 03.

Artículo en Inglés | MEDLINE | ID: mdl-38527005

6.

TENAYA and LUCERNE: Two-Year Results from the Phase 3 Neovascular Age-Related Macular Degeneration Trials of Faricimab with Treat-and-Extend Dosing in Year 2.

Khanani, Arshad M; Kotecha, Aachal; Chang, Andrew; Chen, Shih-Jen; Chen, Youxin; Guymer, Robyn; Heier, Jeffrey S; Holz, Frank G; Iida, Tomohiro; Ives, Jane A; Lim, Jennifer I; Lin, Hugh; Michels, Stephan; Quezada Ruiz, Carlos; Schmidt-Erfurth, Ursula; Silverman, David; Singh, Rishi; Swaminathan, Balakumar; Willis, Jeffrey R; Tadayoni, Ramin.

Ophthalmology; 2024 Feb 19.

Artículo en Inglés | MEDLINE | ID: mdl-38382813

7.

Treatment of geographic atrophy: an update on data related to pegcetacoplan.

Patel, Sagar B; Heier, Jeffrey S; Chaudhary, Varun; Wykoff, Charles C.

Curr Opin Ophthalmol; 35(1): 64-72, 2024 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-37815317

8.

SUPRACHOROIDAL SPACE INJECTION TECHNIQUE: Expert Panel Guidance.

Wykoff, Charles C; Avery, Robert L; Barakat, Mark R; Boyer, David S; Brown, David M; Brucker, Alexander J; Cunningham, Emmett T; Heier, Jeffrey S; Holekamp, Nancy M; Kaiser, Peter K; Khanani, Arshad M; Kim, Judy E; Demirci, Hakan; Regillo, Carl D; Yiu, Glenn C; Ciulla, Thomas A.

Retina; 44(6): 939-949, 2024 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-38451179

9.

Efficacy, durability, and safety of intravitreal faricimab up to every 16 weeks for neovascular age-related macular degeneration (TENAYA and LUCERNE): two randomised, double-masked, phase 3, non-inferiority trials.

Heier, Jeffrey S; Khanani, Arshad M; Quezada Ruiz, Carlos; Basu, Karen; Ferrone, Philip J; Brittain, Christopher; Figueroa, Marta S; Lin, Hugh; Holz, Frank G; Patel, Vaibhavi; Lai, Timothy Y Y; Silverman, David; Regillo, Carl; Swaminathan, Balakumar; Viola, Francesco; Cheung, Chui Ming Gemmy; Wong, Tien Y.

Lancet; 399(10326): 729-740, 2022 02 19.

Artículo en Inglés | MEDLINE | ID: mdl-35085502

10.

RETINAL VASCULITIS OR VASCULAR OCCLUSION AFTER BROLUCIZUMAB FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Systematic Review of Real-World Evidence.

Wykoff, Charles C; Matsumoto, Hidetaka; Barakat, Mark R; Karcher, Helene; Lozama, Anthony; Mayhook, Andrew; Oshagbemi, Olorunfemi A; Zorina, Olessia; Hassan, Tarek S; Khanani, Arshad M; Heier, Jeffrey S.

Retina; 43(7): 1051-1063, 2023 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-36893438

11.

MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal Fluid.

Khanani, Arshad M; Brown, David M; Jaffe, Glenn J; Wykoff, Charles C; Adiguzel, Eser; Wong, Randall; Meng, Xiangyi; Heier, Jeffrey S.

Ophthalmology; 129(9): 974-985, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35537533

12.

INTRAVITREAL NESVACUMAB (ANTIANGIOPOIETIN 2) PLUS AFLIBERCEPT IN DIABETIC MACULAR EDEMA: Phase 2 RUBY Randomized Trial.

Brown, David M; Boyer, David S; Csaky, Karl; Vitti, Robert; Perlee, Lorah; Chu, Karen W; Asmus, Friedrich; Leal, Sergio; Zeitz, Oliver; Cheng, Yenchieh; Schmelter, Thomas; Heier, Jeffrey S.

Retina; 42(6): 1111-1120, 2022 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-35234673

13.

Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.

Monés, Jordi; Srivastava, Sunil K; Jaffe, Glenn J; Tadayoni, Ramin; Albini, Thomas A; Kaiser, Peter K; Holz, Frank G; Korobelnik, Jean-Francois; Kim, Ivana K; Pruente, Christian; Murray, Timothy G; Heier, Jeffrey S.

Ophthalmology; 128(7): 1050-1059, 2021 07.

Artículo en Inglés | MEDLINE | ID: mdl-33207259

14.

THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES: A Review.

Heier, Jeffrey S; Singh, Rishi P; Wykoff, Charles C; Csaky, Karl G; Lai, Timothy Y Y; Loewenstein, Anat; Schlottmann, Patricio G; Paris, Liliana P; Westenskow, Peter D; Quezada-Ruiz, Carlos.

Retina; 41(1): 1-19, 2021 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-33136975

15.

Intravitreal Combined Aflibercept + Anti-Platelet-Derived Growth Factor Receptor ß for Neovascular Age-Related Macular Degeneration: Results of the Phase 2 CAPELLA Trial.

Heier, Jeffrey S; Wykoff, Charles C; Waheed, Nadia K; Kitchens, John W; Patel, Sunil S; Vitti, Robert; Perlee, Lorah; Chu, Karen W; Leal, Sergio; Asmus, Friedrich; Son, Vladimir; Schmelter, Thomas; Brown, David M.

Ophthalmology; 127(2): 211-220, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31791663

16.

Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.

Liao, David S; Grossi, Federico V; El Mehdi, Delphine; Gerber, Monica R; Brown, David M; Heier, Jeffrey S; Wykoff, Charles C; Singerman, Lawrence J; Abraham, Prema; Grassmann, Felix; Nuernberg, Peter; Weber, Bernhard H F; Deschatelets, Pascal; Kim, Robert Y; Chung, Carol Y; Ribeiro, Ramiro M; Hamdani, Mohamed; Rosenfeld, Philip J; Boyer, David S; Slakter, Jason S; Francois, Cedric G.

Ophthalmology; 127(2): 186-195, 2020 02.

Artículo en Inglés | MEDLINE | ID: mdl-31474439

17.

Intravitreous injection of AAV2-sFLT01 in patients with advanced neovascular age-related macular degeneration: a phase 1, open-label trial.

Heier, Jeffrey S; Kherani, Saleema; Desai, Shilpa; Dugel, Pravin; Kaushal, Shalesh; Cheng, Seng H; Delacono, Cheryl; Purvis, Annie; Richards, Susan; Le-Halpere, Annaig; Connelly, John; Wadsworth, Samuel C; Varona, Rafael; Buggage, Ronald; Scaria, Abraham; Campochiaro, Peter A.

Lancet; 390(10089): 50-61, 2017 07 01.

Artículo en Inglés | MEDLINE | ID: mdl-28526489

18.

Emixustat Hydrochloride for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Clinical Trial.

Rosenfeld, Philip J; Dugel, Pravin U; Holz, Frank G; Heier, Jeffrey S; Pearlman, Joel A; Novack, Roger L; Csaky, Karl G; Koester, John M; Gregory, Jeffrey K; Kubota, Ryo.

Ophthalmology; 125(10): 1556-1567, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-29716784

19.

Reply.

Heier, Jeffrey S.

Ophthalmology; 128(9): e47-e48, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34053735

20.

Outcomes after Failed Pneumatic Retinopexy for Retinal Detachment.

Anaya, Joseph A; Shah, Chirag P; Heier, Jeffrey S; Morley, Michael G.

Ophthalmology; 123(5): 1137-42, 2016 May.

Artículo en Inglés | MEDLINE | ID: mdl-26952593

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