Detalles de la búsqueda
1.
Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam.
Drug Metab Dispos;
50(1): 65-75, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34620695
2.
Effect of mild or moderate hepatic impairment on the pharmacokinetics of risdiplam.
Br J Clin Pharmacol;
88(8): 3749-3759, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35301746
3.
Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers.
Pharm Res;
39(4): 653-667, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35338426
4.
A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.
Br J Clin Pharmacol;
85(1): 181-193, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30302786
5.
Absorption, distribution, metabolism and excretion (ADME) of the ALK inhibitor alectinib: results from an absolute bioavailability and mass balance study in healthy subjects.
Xenobiotica;
47(3): 217-229, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-27180975
6.
Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling.
Clin Transl Sci;
16(6): 1085-1096, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36978270
7.
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children.
Clin Pharmacokinet;
62(6): 891-904, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37148485
8.
Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.
Drug Metab Dispos;
40(8): 1556-65, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22584254
9.
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species.
J Pharmacol Toxicol Methods;
115: 107167, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35301126
10.
Dalcetrapib pharmacokinetics and metabolism in the cynomolgus monkey.
Xenobiotica;
41(5): 430-6, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21348578
11.
An improved LC-MS/MS method for the determination of taspoglutide in plasma and urine using orthogonal HILIC-RP column switching, ultra-performance LC separation and 'wrong-way-round' electrospray ionization.
Biomed Chromatogr;
25(11): 1215-21, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21308702
12.
Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children: Risdiplam in Pediatric Patients With Spinal Muscular Atrophy.
Clin Pharmacol Ther;
110(6): 1547-1557, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34347881
13.
Determination of taspoglutide in human and animal plasma using liquid chromatography-tandem mass spectrometry with orthogonal column-switching.
Anal Chem;
81(10): 3705-13, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19374429
14.
Inconsistent internal standard response in LC-MS/MS bioanalysis: an evaluation of case studies.
Bioanalysis;
11(18): 1657-1667, 2019 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31556309
15.
The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy.
Neuromuscul Disord;
29(1): 21-29, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30553700
16.
Sensitive determination of oseltamivir and oseltamivir carboxylate in plasma, urine, cerebrospinal fluid and brain by liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci;
876(1): 129-36, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19004673
17.
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs.
Pharmacol Res Perspect;
6(6): e00447, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30519476
18.
Ocular bioanalysis: challenges and advancements in recent years for these rare matrices.
Bioanalysis;
9(24): 1997-2014, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29205056
19.
LC-MS/MS determination of alectinib and its major human metabolite M4 in human urine: prevention of nonspecific binding.
Bioanalysis;
9(5): 459-468, 2017 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-28176528
20.
Bioanalysis of alectinib and metabolite M4 in human plasma, cross-validation and impact on PK assessment.
Bioanalysis;
8(14): 1465-79, 2016 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27329641