RESUMEN
We assembled genome-wide data from 16 prehistoric Africans. We show that the anciently divergent lineage that comprises the primary ancestry of the southern African San had a wider distribution in the past, contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers â¼8,100-2,500 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers â¼1,400 years ago. We document how the spread of farmers from western Africa involved complete replacement of local hunter-gatherers in some regions, and we track the spread of herders by showing that the population of a â¼3,100-year-old pastoralist from Tanzania contributed ancestry to people from northeastern to southern Africa, including a â¼1,200-year-old southern African pastoralist. The deepest diversifications of African lineages were complex, involving either repeated gene flow among geographically disparate groups or a lineage more deeply diverging than that of the San contributing more to some western African populations than to others. We finally leverage ancient genomes to document episodes of natural selection in southern African populations. PAPERCLIP.
Asunto(s)
Población Negra/genética , Genoma Humano , África , Huesos/química , ADN Antiguo/análisis , Femenino , Fósiles , Genética Médica , Genética de Población , Estudio de Asociación del Genoma Completo , Humanos , Estilo de Vida , MasculinoRESUMEN
The number of possible small organic molecules of different structure is virtually limitless. One of the main goals of chemical biologists is to identify, from this "chemical space", entities that affect biological processes or systems in a specific manner. This can lead to a better understanding of the regulation and components of various biological machineries, as well as provide insights into efficacious therapeutic targets and drug candidates. However, the challenges confronting chemical biologists are multiple. How do we efficiently identify compounds that possess desirable activities without unwanted off-target effects? Once a candidate compound has been found, how do we determine its mode of action? In this Prospects piece, we call attention to recent studies using embryonic and larval zebrafish to illustrate the breadth and depth of questions in chemical biology that may be addressed using this model, and hope that they can serve as catalysts for future investigational ideas.