Carcinoma ex pleomorphic adenoma of the submandibular gland with distant metastases.

A case of metastatic carcinoma ex pleomorphic adenoma (PA) of the submandibular gland is reported. While reports of local recurrence of this cancer are numerous, few cases of distant metastases have been reported. We report a case of a 52-year-old male patient with a history of PA diagnosed ten years previous. The patient presented reporting that the mass had increased size and pain during the previous six months. Needle biopsy results of this mass were compatible with a poorly differentiated carcinoma of the salivary ducts. Radical surgery with wide right neck dissection was performed with curative intent. Three years post-surgery liver and bony metastases were detected. In conclusion, the potential for malignant transformation of PA demands close follow-up of younger patients.

Submucosal glands and goblet cells in maxillary sinus surgery: an experimental study in rabbits.

HYPOTHESIS: After sinus surgery poor ciliary activity and disorders in mucus production can lead to an increase in postoperative complications. PURPOSE OF THIS STUDY: To evaluate the changes in the ultrastructure of submucosal glands (SG) and goblet cells (GC) after partial or wide surgical removal of maxillary sinus mucosa (MSM). METHODS: Twenty New Zealand White rabbits were divided in two groups of 10 animals. In group A, the mucosa of the right maxillary sinus (MS) was removed. In contrast, in group B only a strip the mucosa around the ostium was removed. After three months the sinus were opened and the mucosa studied by light-, and scanning- and transmision electron microscopy. RESULTS: After three months in group A all right MS were infected with purulent secretions, and the density of SG with a mean value of 10.4 per mm, standard deviation (SD) 3.36 and GC 81.81 per mm (SD: 3.82). However, in group B the SG were 52.3 per mm (SD: 4.5) and GC 4.45 per mm (SD: 1.23). These results were statistically significant (p < 0.001). Histopathological findings showed in group A, after three months, SG with a fewer number of microvilli in the glandular lumen.

A correlation between age and Actinomyces in the adenotonsillar tissue of children.

The purpose of this study was to investigate the presence of actinomyces in adenotonsillar disease, recurrent infections, or tonsillar hypertrophy in children. The study included 64 patients, ranging in age from 2 to 16 years, who had elective adenotonsillar surgery to treat either adenotonsillar hypertrophy (36 children) or recurrent adenotonsillitis (28 children). Adenotonsillar Actinomyces was present in 30 children (48%). No statistical significance was found between Actinomyces and recurrent adenotonsillitis or adenotonsillar hypertrophy. However, there was a statistically significant relationship identified between the presence of actinomycosis and age, with a greater occurrence of actinomycosis in children between 5 and 16 years old.

Merkel cell carcinoma in the nasal cavity: a case report.

Merkel cell carcinoma is an aggressive dermal neoplasm of neuroendocrine origin with a predilection for the head-and-neck region in elderly patients. We present a case of Merkel cell carcinoma of the nasal fossa. Local wide excision was performed.

Different glycoconjugates in the submucosal glands of the supraglottis and subglottis. Lectin histochemistry study in the hamster.

A lectin histochemistry study was performed in the supraglottic and subglottic regions of 10 hamsters. The submucosal glands were observed by light microscopy. The supraglottic submucosal glands presented numerous mucous tubules but on the other hand, the subglottic submucosal glands had serous tubules which finished at the distal portion in serous acini. The results suggest that the distribution of fucosylated-mucin and serum-type glycoproteins between the supra- and subglottic submucosal glands suggest a different viscosity and function of the mucus.

Submucosal glands after maxillary sinus surgery. An experimental study in rabbits.

Thirty New Zealand White rabbits underwent unilateral partial or complete removal of maxillary sinus mucosa in order to evaluate submucosal maxillary sinus glands. After three months, specimens were taken for examination from all operated on and control sinuses. Bacteriological cultures, light and electron microscopy were performed. Histopathological findings showed a decrease in the number of serous glands and significant inflammation was present in the sinus in which there was complete surgical removal. Electron microscopy revealed changes in the secretory cells of the serous glands in the regenerated post-surgical mucosa.

Sudden deafness and cerebellar tumour.

We report the case of a female patient who presented with sudden deafness as the first symptom of a cerebellar tumour which was not localized strictly in the cerebellopontine angle and did not show direct compression on the extrabulbar portion of the VIIIth cranial nerve. The clinical picture contained a number of signs and symptoms typical of cerebellar involvement. Surgical intervention restored the hearing and caused the symptoms to disappear. We also review the association between tumours and sudden deafness in the literature.

[Nasal mucociliary transport in normal subjects]. / Transporte mucociliar nasal en sujetos normales.

Clinical study referred to the nasal mucociliary transport of 132 healthy people, by means of the charcoal powder method. Intranasal clearance direction of the marker, the degree of the test's reproductiveness and the influence on the clearance of certain variables are considered. With this procedure the study of the nasociliary transportation time become simple, cheap, reliable, reproducible and objective. There are great individual variations of the nasal transport-time, but it is relatively constant in each examinee. The number of slow markers is scarce. The age, the sex, tobacco and the feminine cycle have no influential effect in the nasal mucociliary transport-time.

[Differences between epiglottis and cricoid cartilages. Histochemical study with lectins in hamsters]. / Diferencias entre el cartílago de epiglotis y el de cricoides. Estudio histoquímico con lectinas en el hámster.

An histochemistry study with lectins was performed in the epiglottis and cricoid cartilages of 4 Syrian golden hamsters (Mesocricetus auratus). The results show that there are differences in glycoconjugates between both cartilages. In the epiglottic matrix there was no reactivity to HPA, PNA and DBA lectins. However the cricoid cartilage showed no reactivity to SBA. Neither of cartilage matrixes were reactive to LTA or Con-A.

[Pleomorphic adenoma as a parapharyngeal tumor. The role of the CT in differential diagnosis]. / El adenoma pleomorfo como tumor parafaríngeo. Papel de la TAC en el diagnóstico diferencial.

We described 2 cases of pleomorphic adenoma as parapharyngeal masses, one of the deep lobule of the parotid gland and the other one in palatine accessory salivary glands. After computed tomography (CAT) we made the anatomopathological diagnosis of pleomorphic adenoma with fine needle aspiration. We discuss about the role of CAT in diagnosis of pleomorphic adenoma occupying the parapharyngeal space.

[Pharyngeal lipoma]. / Pharyngeal lipoma.

We present a 40-year-old male patient with a lump in the parapharyngeal space protruding in the oro- and hypopharynx and obstructing the airway. Diagnosis lipoma. The pathology is reviewed and the surgical approach is commented upon.

[Adenoidectomy and nasal mucociliary transport]. / Adenoidectomía y transporte mucociliar nasal.

The paper deals with the research done by the AA. on the nasal mucociliary transport-time in a group of 30 children between 3 and 13-year-old. They employ the charcoal dust test. The powder is laid inside of the nose the day prior to the removal of the adenoids and investigated in the nasopharynx two weeks later. The conclusion drawn out is that among these children the mucociliary nasal transport time is retarded when compared with other children, turning over to the normality two weeks later.

[The influence of pregnancy on mucociliary nasal transport]. / Influencia de la gestación en el transporte mucociliar nasal.

In 30 pregnant healthy women and other 70 healthy but non pregnant the AA. study the mucociliary nasal transport-time, using the charcoal method. The conclusion drawn out is that during the pregnancy the transport-time is meaningly reduced and the pregnants shows characteristic nasal signs and symptoms.

[Pharyngostoma following total laryngectomy]. / Faringostoma tras laringectomía total.

Prospective study following 32 total laryngectomees with the aim of compare the efficacy of the pharyngo-esophageal closure alternatively stiching with vicryl and catgut. The use of vicryl resulted in 31 percent pharyngocutaneous fistulae versus 61 percent with catgut.

[Lymphoepithelial cysts of the parotid gland. Its association with immunodeficiency virus infection]. / Quistes linfoepiteliales de glándula parótida: su relación con la infección por virus de la inmunodeficiencia humana.

Lymphoepithelial cysts of the parotid gland are frequently associated with HIV disease. We describe a case of a patient positive for HIV antibodies, stade A2, and extracapsular, bilateral and symmetric lymphoepithelial cysts of the parotid. The diagnosis was achieved by biopsy following a cervicotomy. A prior needle-biopsy procedure was disappointing. Literature review and discussion about the source and envolvement of those cysts linked to HIV-infection.

[Histochemical study with lectins submucous glands of the hamster's tongue]. / Estudio histoquímico mediante lectinas de las glándulas submucosas linguales. Estudio en el hámster.

A histochemical study, with lectins, in oropharyngeal cavity of 5 Syrian golden Hamsters (Mesocricetus auratus) was performed in order to know the tongue submucous glands characteristics. Results showed a strong reactivity to HPA lectin for secretions of submucous glands of the Hamster's tongue and a slight reactivity to N-WGA and to WGA lectins.

[The rat's vomeronasal organ. Histochemical study with lectins]. / El órgano vomeronasal de la rata. Estudio histoquímico mediante lectinas.

A histochemistry study by means of lectins of vomeronasal organ or Jacobson's organ was performed in 5 Wistar rats. Vomeronasal organ is localized at the antero-inferior level of the septum and present two kinds of epithelium, an olfactory one and other respiratory, on the medial and on the lateral part, respectively. Olfactory epithelium shows a great reactivity to WGA lectin, moderate to PNA and weck to Con-A and SBA. In the respiratory epithelium the reactivity is moderate to DBA, PNa, SBA and WGA lectins for goblet cells, instead the periciliary sheat of mucus is reactive to all lectins but DBA and LTA.

[Olfactory epithelium of the rat. Lectin-mediated histochemical studies]. / El epitelio olfatorio de la rata. Estudio histoquímico mediante lectinas.

A histochemical study with lectins of the olfactory epithelium of 5 Wistar rats was performed. This neuro-epithelium cover the postero-superior part of the nasal cavity and the medial part of the vomeronasal organon. There are numerous Bowman's glands in the olfactory epithelium, besides the sensory cells. These glandulae dye as well with PAS.AB, the same as the mucosal layer over the epithelium, which show its composition on sialo-sulfomucines. The mucous layer over the olfactory epithelium shows a great reactivity to WGA, moderate to PNA and Con-A and weak to SBA. On the other hand Bowman's glands show an intense reactivity to PNA and moderate to WGA, VEA-I and to Con-A.

[Histochemical differences between submucous glands and Goblet cells of the supraglottis. A study on hamsters]. / Diferencias histoquímicas entre las glándulas submucosas y las células caliciformes de la supraglotis. Estudio en el hámster.

In order to know the differences between the submucosal glands and the goblet cells of the supraglottic mucosa, a lectin histochemistry study was performed in 4 larynx of hamster (Mesocricetus auratus). The results show a strong reactivity to HPA and N-WGA lectins in the submucosal glands. Also reactivity to N-PNA and UEA-1 was present in the submucous glands but not in the goblet cells.

[Eosinophilic ulcers of the tongue as an adverse reaction to carbamazepine]. / Ulcera eosinofílica de la lengua como reacción adversa a la carbamazepina.

We describe a typical case of eosinophilic ulcer of the oral mucosa (EUOM) after an adverse reaction to carbamazepine, in a manic-depressive patient. This case may be suggestive of other etiologic factors for the EUOM, different to traumas.