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1.

SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.

Chugh, Rashmi; Ballman, Karla V; Helman, Lee J; Patel, Shreyaskumar; Whelan, Jeremy S; Widemann, Brigitte; Lu, Yao; Hawkins, Douglas S; Mascarenhas, Leo; Glod, John W; Ji, Jiuping; Zhang, Yiping; Reinke, Denise; Strauss, Sandra J.

Cancer; 127(8): 1301-1310, 2021 04 15.

Artículo en Inglés | MEDLINE | ID: mdl-33289920

2.

LRRC15 antibody-drug conjugates show promise as osteosarcoma therapeutics in preclinical studies.

Slemmons, Katherine K; Mukherjee, Sanjit; Meltzer, Paul; Purcell, James W; Helman, Lee J.

Pediatr Blood Cancer; 68(2): e28771, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33063919

3.

New Horizons in the Treatment of Osteosarcoma.

Meltzer, Paul S; Helman, Lee J.

N Engl J Med; 385(22): 2066-2076, 2021 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-34818481

4.

Insights into pediatric rhabdomyosarcoma research: Challenges and goals.

Yohe, Marielle E; Heske, Christine M; Stewart, Elizabeth; Adamson, Peter C; Ahmed, Nabil; Antonescu, Cristina R; Chen, Eleanor; Collins, Natalie; Ehrlich, Alan; Galindo, Rene L; Gryder, Berkley E; Hahn, Heidi; Hammond, Sharon; Hatley, Mark E; Hawkins, Douglas S; Hayes, Madeline N; Hayes-Jordan, Andrea; Helman, Lee J; Hettmer, Simone; Ignatius, Myron S; Keller, Charles; Khan, Javed; Kirsch, David G; Linardic, Corinne M; Lupo, Philip J; Rota, Rossella; Shern, Jack F; Shipley, Janet; Sindiri, Sivasish; Tapscott, Stephen J; Vakoc, Christopher R; Wexler, Leonard H; Langenau, David M.

Pediatr Blood Cancer; 66(10): e27869, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31222885

5.

Risk-Based Therapy for Localized Osteosarcoma.

Venkatramani, Rajkumar; Murray, Jeffrey; Helman, Lee; Meyer, William; Hicks, M John; Krance, Robert; Lau, Ching; Jo, Eunji; Chintagumpala, Murali.

Pediatr Blood Cancer; 63(3): 412-7, 2016 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-26501936

6.

Compressing drug development timelines in oncology using phase '0' trials.

Kummar, Shivaani; Kinders, Robert; Rubinstein, Larry; Parchment, Ralph E; Murgo, Anthony J; Collins, Jerry; Pickeral, Oxana; Low, Jennifer; Steinberg, Seth M; Gutierrez, Martin; Yang, Sherry; Helman, Lee; Wiltrout, Robert; Tomaszewski, Joseph E; Doroshow, James H.

Nat Rev Cancer; 7(2): 131-9, 2007 02.

Artículo en Inglés | MEDLINE | ID: mdl-17251919

7.

A phase 2 trial of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor (IGF-1R), in patients with recurrent or refractory rhabdomyosarcoma, osteosarcoma, synovial sarcoma, and other soft tissue sarcomas: results of a Sarcoma Alliance for Research Through Collaboration study.

Pappo, Alberto S; Vassal, Gilles; Crowley, John J; Bolejack, Vanessa; Hogendoorn, Pancras C W; Chugh, Rashmi; Ladanyi, Marc; Grippo, Joseph F; Dall, Georgina; Staddon, Arthur P; Chawla, Sant P; Maki, Robert G; Araujo, Dejka M; Geoerger, Birgit; Ganjoo, Kristen; Marina, Neyssa; Blay, Jean-Yves; Schuetze, Scott M; Chow, Warren A; Helman, Lee J.

Cancer; 120(16): 2448-56, 2014 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-24797726

8.

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations.

Janeway, Katherine A; Kim, Su Young; Lodish, Maya; Nosé, Vânia; Rustin, Pierre; Gaal, José; Dahia, Patricia L M; Liegl, Bernadette; Ball, Evan R; Raygada, Margarita; Lai, Angela H; Kelly, Lorna; Hornick, Jason L; O'Sullivan, Maureen; de Krijger, Ronald R; Dinjens, Winand N M; Demetri, George D; Antonescu, Cristina R; Fletcher, Jonathan A; Helman, Lee; Stratakis, Constantine A.

Proc Natl Acad Sci U S A; 108(1): 314-8, 2011 Jan 04.

Artículo en Inglés | MEDLINE | ID: mdl-21173220

9.

Mechanisms of sarcoma development.

Helman, Lee J; Meltzer, Paul.

Nat Rev Cancer; 3(9): 685-94, 2003 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-12951587

10.

Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.

Akshintala, Srivandana; Sundby, R Taylor; Bernstein, Donna; Glod, John W; Kaplan, Rosandra N; Yohe, Marielle E; Gross, Andrea M; Derdak, Joanne; Lei, Haiyan; Pan, Alexander; Dombi, Eva; Palacio-Yance, Isabel; Herrera, Kailey R; Miettinen, Markku M; Chen, Helen X; Steinberg, Seth M; Helman, Lee J; Mascarenhas, Leo; Widemann, Brigitte C; Navid, Fariba; Shern, Jack F; Heske, Christine M.

Clin Cancer Res; 29(17): 3329-3339, 2023 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-37398992

11.

A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-Associated Renal Cell Carcinoma.

Ligon, John A; Sundby, R Taylor; Wedekind, Mary F; Arnaldez, Fernanda I; Del Rivero, Jaydira; Wiener, Lori; Srinivasan, Ramaprasad; Spencer, Melissa; Carbonell, Amanda; Lei, Haiyan; Shern, John; Steinberg, Seth M; Figg, William D; Peer, Cody J; Zimmerman, Sara; Moraly, Josquin; Xu, Xia; Fox, Stephen; Chan, King; Barbato, Michael I; Andresson, Thorkell; Taylor, Naomi; Pacak, Karel; Killian, J Keith; Dombi, Eva; Linehan, W Marston; Miettinen, Markku; Piekarz, Richard; Helman, Lee J; Meltzer, Paul; Widemann, Brigitte; Glod, John.

Clin Cancer Res; 29(2): 341-348, 2023 01 17.

Artículo en Inglés | MEDLINE | ID: mdl-36302175

12.

The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer.

Flores-Toro, Joseph A; Jagu, Subhashini; Armstrong, Gregory T; Arons, David F; Aune, Gregory J; Chanock, Stephen J; Hawkins, Douglas S; Heath, Allison; Helman, Lee J; Janeway, Katherine A; Levine, Jason E; Miller, Ellyn; Penberthy, Lynne; Roberts, Charles W M; Shalley, Eve R; Shern, Jack F; Smith, Malcolm A; Staudt, Louis M; Volchenboum, Samuel L; Zhang, Jinghui; Zenklusen, Jean Claude; Lowy, Douglas R; Sharpless, Norman E; Guidry Auvil, Jaime M; Kerlavage, Anthony R; Widemann, Brigitte C; Reaman, Gregory H; Kibbe, Warren A; Doroshow, James H.

J Clin Oncol; 41(24): 4045-4053, 2023 08 20.

Artículo en Inglés | MEDLINE | ID: mdl-37267580

13.

Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003.

Fox, Elizabeth; Patel, Shreyaskumar; Wathen, J Kyle; Schuetze, Scott; Chawla, Sant; Harmon, David; Reinke, Denise; Chugh, Rashmi; Benjamin, Robert S; Helman, Lee J.

Oncologist; 17(3): 321, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-22363068

14.

Thyroid hormone inactivation in gastrointestinal stromal tumors.

Boikos, Sosipatros A; Helman, Lee J; Stratakis, Constantine A.

N Engl J Med; 371(1): 85-6, 2014 07 03.

Artículo en Inglés | MEDLINE | ID: mdl-24988575

15.

Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells.

Zhang, Hua; Chua, Kevin S; Guimond, Martin; Kapoor, Veena; Brown, Margaret V; Fleisher, Thomas A; Long, Lauren M; Bernstein, Donna; Hill, Brenna J; Douek, Daniel C; Berzofsky, Jay A; Carter, Charles S; Read, E J; Helman, Lee J; Mackall, Crystal L.

Nat Med; 11(11): 1238-43, 2005 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-16227988

16.

The new kid on the block(ade) of the IGF-1 receptor.

LeRoith, Derek; Helman, Lee.

Cancer Cell; 5(3): 201-2, 2004 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-15050909

17.

Gastrointestinal stromal tumor: psychosocial characteristics and considerations.

Wiener, Lori; Battles, Haven; Zadeh, Sima; Smith, Carly J; Helman, Lee J; Kim, Su Young.

Support Care Cancer; 20(6): 1343-9, 2012 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-22426502

18.

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators.

Yu, Yanlin; Khan, Javed; Khanna, Chand; Helman, Lee; Meltzer, Paul S; Merlino, Glenn.

Nat Med; 10(2): 175-81, 2004 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-14704789

19.

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis.

Khanna, Chand; Wan, Xiaolin; Bose, Seuli; Cassaday, Ryan; Olomu, Osarenoma; Mendoza, Arnulfo; Yeung, Choh; Gorlick, Richard; Hewitt, Stephen M; Helman, Lee J.

Nat Med; 10(2): 182-6, 2004 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-14704791

20.

Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.

Sharp, Richard; Recio, Juan A; Jhappan, Chamelli; Otsuka, Toshiyuki; Liu, Shiquan; Yu, Yanlin; Liu, Wenjing; Anver, Miriam; Navid, Fariba; Helman, Lee J; DePinho, Ronald A; Merlino, Glenn.

Nat Med; 8(11): 1276-80, 2002 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-12368906

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