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1.
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Nat Immunol;
21(2): 145-157, 2020 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31932810
2.
The FAM13A Long Isoform Regulates Cilia Movement and Co-ordination in Airway Mucociliary Transport.
Am J Respir Cell Mol Biol;
2024 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38691660
3.
Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Am J Respir Cell Mol Biol;
65(5): 544-554, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34181859
4.
PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
BMC Immunol;
22(1): 78, 2021 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34920698
5.
Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.
Biophys J;
119(12): 2403-2417, 2020 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33217385
6.
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Drug Metab Dispos;
48(4): 307-316, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32009006
7.
Use of autologous 99mTechnetium-labelled neutrophils to quantify lung neutrophil clearance in COPD.
Thorax;
74(7): 659-666, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30674586
8.
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.
J Pharmacol Exp Ther;
369(3): 443-453, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940692
9.
An Innovative Approach to Characterize Clinical ADME and Pharmacokinetics of the Inhaled Drug Nemiralisib Using an Intravenous Microtracer Combined with an Inhaled Dose and an Oral Radiolabel Dose in Healthy Male Subjects.
Drug Metab Dispos;
47(12): 1457-1468, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31649125
10.
Airway host-microbiome interactions in chronic obstructive pulmonary disease.
Respir Res;
20(1): 113, 2019 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31170986
11.
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
J Pharmacol Exp Ther;
367(3): 405-413, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30217958
12.
An investigation of the anti-inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells.
Clin Exp Pharmacol Physiol;
44(9): 932-940, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28508433
13.
Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition.
Am J Respir Crit Care Med;
194(8): 961-973, 2016 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27064380
14.
Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome.
Lancet;
385 Suppl 1: S55, 2015 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-26312877
15.
Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model.
Pharm Res;
33(11): 2604-16, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27401409
16.
Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Eur Respir J;
55(5)2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32060058
17.
A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.
Thorax;
69(6): 565-573, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24464743
18.
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.
Nat Med;
13(5): 552-9, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17479101
19.
Histamine-secreting microbes are increased in the gut of adult asthma patients.
J Allergy Clin Immunol;
138(5): 1491-1494.e7, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27576125
20.
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Clin Pharmacokinet;
61(2): 281-293, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34458976