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1.

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Soldner, Frank; Laganière, Josée; Cheng, Albert W; Hockemeyer, Dirk; Gao, Qing; Alagappan, Raaji; Khurana, Vikram; Golbe, Lawrence I; Myers, Richard H; Lindquist, Susan; Zhang, Lei; Guschin, Dmitry; Fong, Lauren K; Vu, B Joseph; Meng, Xiangdong; Urnov, Fyodor D; Rebar, Edward J; Gregory, Philip D; Zhang, H Steve; Jaenisch, Rudolf.

Cell; 146(2): 318-31, 2011 Jul 22.

Artículo en Inglés | MEDLINE | ID: mdl-21757228

2.

Cancer-associated POT1 mutations lead to telomere elongation without induction of a DNA damage response.

Kim, Won-Tae; Hennick, Kelsey; Johnson, Joshua; Finnerty, Brendan; Choo, Seunga; Short, Sarah B; Drubin, Casey; Forster, Ryan; McMaster, Mary L; Hockemeyer, Dirk.

EMBO J; 40(12): e107346, 2021 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-33934394

3.

Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita.

Choo, Seunga; Lorbeer, Franziska K; Regalado, Samuel G; Short, Sarah B; Wu, Shannon; Rieser, Gabrielle; Bertuch, Alison A; Hockemeyer, Dirk.

Blood; 140(6): 608-618, 2022 08 11.

Artículo en Inglés | MEDLINE | ID: mdl-35421215

4.

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.

Sfeir, Agnel; Kosiyatrakul, Settapong T; Hockemeyer, Dirk; MacRae, Sheila L; Karlseder, Jan; Schildkraut, Carl L; de Lange, Titia.

Cell; 138(1): 90-103, 2009 Jul 10.

Artículo en Inglés | MEDLINE | ID: mdl-19596237

5.

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Soldner, Frank; Hockemeyer, Dirk; Beard, Caroline; Gao, Qing; Bell, George W; Cook, Elizabeth G; Hargus, Gunnar; Blak, Alexandra; Cooper, Oliver; Mitalipova, Maisam; Isacson, Ole; Jaenisch, Rudolf.

Cell; 136(5): 964-77, 2009 Mar 06.

Artículo en Inglés | MEDLINE | ID: mdl-19269371

6.

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.

Sexton, Alec N; Regalado, Samuel G; Lai, Christine S; Cost, Gregory J; O'Neil, Colleen M; Urnov, Fyodor D; Gregory, Philip D; Jaenisch, Rudolf; Collins, Kathleen; Hockemeyer, Dirk.

Genes Dev; 28(17): 1885-99, 2014 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-25128433

7.

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Gao, Qing; Steine, Eveline J; Barrasa, M Inmaculada; Hockemeyer, Dirk; Pawlak, Mathias; Fu, Dongdong; Reddy, Seshamma; Bell, George W; Jaenisch, Rudolf.

Proc Natl Acad Sci U S A; 108(44): 18061-6, 2011 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-22011581

8.

Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells.

Li, Hanqin; Bartke, Rebecca; Zhao, Lei; Verma, Yogendra; Horacek, Anna; Rechav Ben-Natan, Alma; Pangilinan, Gabriella R; Krishnappa, Netravathi; Nielsen, Rasmus; Hockemeyer, Dirk.

Nat Biomed Eng; 8(2): 165-176, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-37488236

9.

Distinct senescence mechanisms restrain progression of dysplastic nevi.

Lorbeer, Franziska K; Rieser, Gabrielle; Goel, Aditya; Wang, Meng; Oh, Areum; Yeh, Iwei; Bastian, Boris C; Hockemeyer, Dirk.

PNAS Nexus; 3(2): pgae041, 2024 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-38371417

10.

iSCORE-PD: an isogenic stem cell collection to research Parkinson's Disease.

Busquets, Oriol; Li, Hanqin; Mohieddin Syed, Khaja; Jerez, Pilar Alvarez; Dunnack, Jesse; Bu, Riana Lo; Verma, Yogendra; Pangilinan, Gabriella R; Martin, Annika; Straub, Jannes; Du, YuXin; Simon, Vivien M; Poser, Steven; Bush, Zipporiah; Diaz, Jessica; Sahagun, Atehsa; Gao, Jianpu; Hernandez, Dena G; Levine, Kristin S; Booth, Ezgi O; Bateup, Helen S; Rio, Donald C; Hockemeyer, Dirk; Blauwendraat, Cornelis; Soldner, Frank.

bioRxiv; 2024 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-38405931

11.

Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.

Bredeson, Jessen V; Mudd, Austin B; Medina-Ruiz, Sofia; Mitros, Therese; Smith, Owen Kabnick; Miller, Kelly E; Lyons, Jessica B; Batra, Sanjit S; Park, Joseph; Berkoff, Kodiak C; Plott, Christopher; Grimwood, Jane; Schmutz, Jeremy; Aguirre-Figueroa, Guadalupe; Khokha, Mustafa K; Lane, Maura; Philipp, Isabelle; Laslo, Mara; Hanken, James; Kerdivel, Gwenneg; Buisine, Nicolas; Sachs, Laurent M; Buchholz, Daniel R; Kwon, Taejoon; Smith-Parker, Heidi; Gridi-Papp, Marcos; Ryan, Michael J; Denton, Robert D; Malone, John H; Wallingford, John B; Straight, Aaron F; Heald, Rebecca; Hockemeyer, Dirk; Harland, Richard M; Rokhsar, Daniel S.

Nat Commun; 15(1): 579, 2024 Jan 17.

Artículo en Inglés | MEDLINE | ID: mdl-38233380

12.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

DeKelver, Russell C; Choi, Vivian M; Moehle, Erica A; Paschon, David E; Hockemeyer, Dirk; Meijsing, Sebastiaan H; Sancak, Yasemin; Cui, Xiaoxia; Steine, Eveline J; Miller, Jeffrey C; Tam, Phillip; Bartsevich, Victor V; Meng, Xiangdong; Rupniewski, Igor; Gopalan, Sunita M; Sun, Helena C; Pitz, Kathleen J; Rock, Jeremy M; Zhang, Lei; Davis, Gregory D; Rebar, Edward J; Cheeseman, Iain M; Yamamoto, Keith R; Sabatini, David M; Jaenisch, Rudolf; Gregory, Philip D; Urnov, Fyodor D.

Genome Res; 20(8): 1133-42, 2010 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-20508142

13.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Hargus, Gunnar; Cooper, Oliver; Deleidi, Michela; Levy, Adam; Lee, Kristen; Marlow, Elizabeth; Yow, Alyssa; Soldner, Frank; Hockemeyer, Dirk; Hallett, Penelope J; Osborn, Teresia; Jaenisch, Rudolf; Isacson, Ole.

Proc Natl Acad Sci U S A; 107(36): 15921-6, 2010 Sep 07.

Artículo en Inglés | MEDLINE | ID: mdl-20798034

14.

Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.

Sanchez, Santiago E; Gu, Jessica; Golla, Anudeep; Martin, Annika; Shomali, William; Hockemeyer, Dirk; Savage, Sharon A; Artandi, Steven E.

bioRxiv; 2023 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-38077053

15.

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells.

Turkalo, Timothy K; Maffia, Antonio; Schabort, Johannes J; Regalado, Samuel G; Bhakta, Mital; Blanchette, Marco; Spierings, Diana C J; Lansdorp, Peter M; Hockemeyer, Dirk.

Nat Commun; 14(1): 939, 2023 02 20.

Artículo en Inglés | MEDLINE | ID: mdl-36805596

16.

Distinct senescence mechanisms restrain progression of dysplastic nevi.

Lorbeer, Franziska K; Rieser, Gabrielle; Goel, Aditya; Wang, Meng; Oh, Areum; Yeh, Iwei; Bastian, Boris C; Hockemeyer, Dirk.

bioRxiv; 2023 Jul 16.

Artículo en Inglés | MEDLINE | ID: mdl-37503286

17.

Tracing cancer evolution and heterogeneity using Hi-C.

Erdmann-Pham, Dan Daniel; Batra, Sanjit Singh; Turkalo, Timothy K; Durbin, James; Blanchette, Marco; Yeh, Iwei; Shain, Hunter; Bastian, Boris C; Song, Yun S; Rokhsar, Daniel S; Hockemeyer, Dirk.

Nat Commun; 14(1): 7111, 2023 11 06.

Artículo en Inglés | MEDLINE | ID: mdl-37932252

18.

Genome editing 101: let's go digital.

Forster, Ryan; Hockemeyer, Dirk.

Nat Methods; 11(3): 248-9, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24577275

19.

Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Hockemeyer, Dirk; Palm, Wilhelm; Else, Tobias; Daniels, Jan-Peter; Takai, Kaori K; Ye, Jeffrey Z-S; Keegan, Catherine E; de Lange, Titia; Hammer, Gary D.

Nat Struct Mol Biol; 14(8): 754-61, 2007 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-17632522

20.

Highly efficient generation of isogenic pluripotent stem cell models using prime editing.

Li, Hanqin; Busquets, Oriol; Verma, Yogendra; Syed, Khaja Mohieddin; Kutnowski, Nitzan; Pangilinan, Gabriella R; Gilbert, Luke A; Bateup, Helen S; Rio, Donald C; Hockemeyer, Dirk; Soldner, Frank.

Elife; 112022 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-36069759

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.

Cancer-associated POT1 mutations lead to telomere elongation without induction of a DNA damage response.

Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita.

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation.

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.

Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells.

Distinct senescence mechanisms restrain progression of dysplastic nevi.

iSCORE-PD: an isogenic stem cell collection to research Parkinson's Disease.

Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.

Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.

A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells.

Distinct senescence mechanisms restrain progression of dysplastic nevi.

Tracing cancer evolution and heterogeneity using Hi-C.

Genome editing 101: let's go digital.

Telomere protection by mammalian Pot1 requires interaction with Tpp1.

Highly efficient generation of isogenic pluripotent stem cell models using prime editing.