Detalles de la búsqueda
1.
Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial.
Alcohol Alcohol;
58(2): 134-141, 2023 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36562601
2.
Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury.
Curr Issues Mol Biol;
44(3): 1294-1315, 2022 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35723310
3.
A nuclear factor kappa B reporter cell line used to evaluate ex vivo the net inflammatory effect of plasma samples from patients with rheumatoid arthritis, psoriasis, or COVID-19.
Cytokine;
138: 155399, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33338916
4.
Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses.
Br J Clin Pharmacol;
85(10): 2310-2320, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31222796
5.
Clomethiazole inhibits cytochrome P450 2E1 and improves alcoholic liver disease.
Gut;
71(4): 842-844, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33972357
6.
Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics.
Br J Clin Pharmacol;
83(9): 1954-1965, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28370390
7.
First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B.
J Hepatol;
65(3): 483-9, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27132172
8.
Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.
J Antimicrob Chemother;
71(8): 2241-7, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27141088
9.
St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions.
Arch Toxicol;
90(4): 1013-5, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25963330
10.
Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation.
Molecules;
21(8)2016 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-27463705
11.
Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans.
Br J Clin Pharmacol;
79(2): 278-85, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25588320
12.
Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity.
Br J Clin Pharmacol;
78(6): 1433-40, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139487
13.
Protocol of the IntenSify-Trial: An open-label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab-paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination's pharmacokinetics, safety, and efficacy.
Clin Transl Sci;
16(12): 2483-2493, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37920921
14.
Persister cell phenotypes contribute to poor patient outcomes after neoadjuvant chemotherapy in PDAC.
Nat Cancer;
4(9): 1362-1381, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37679568
15.
Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer.
BMC Cancer;
12: 361, 2012 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22906006
16.
Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1'-hydroxymidazolam in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry.
Anal Bioanal Chem;
402(7): 2439-50, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-22252655
17.
Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion.
Clin Pharmacokinet;
61(11): 1595-1607, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36195807
18.
First-in-human, randomized, double-blind, placebo-controlled, dose escalation trial of the anti-herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers.
Clin Transl Sci;
15(10): 2366-2377, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35869929
19.
Pharmacoenhancement of Low Crizotinib Plasma Concentrations in Patients with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer using the CYP3A Inhibitor Cobicistat.
Clin Transl Sci;
14(2): 487-491, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33222380
20.
Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects.
J Immunother Cancer;
9(10)2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34607895