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1.
Proc Natl Acad Sci U S A ; 117(51): 32244-32250, 2020 Dec 22.
Artículo en Inglés | MEDLINE | ID: mdl-33273119

RESUMEN

What are the ground states of an interacting, low-density electron system? In the absence of disorder, it has long been expected that as the electron density is lowered, the exchange energy gained by aligning the electron spins should exceed the enhancement in the kinetic (Fermi) energy, leading to a (Bloch) ferromagnetic transition. At even lower densities, another transition to a (Wigner) solid, an ordered array of electrons, should occur. Experimental access to these regimes, however, has been limited because of the absence of a material platform that supports an electron system with very high quality (low disorder) and low density simultaneously. Here we explore the ground states of interacting electrons in an exceptionally clean, two-dimensional electron system confined to a modulation-doped AlAs quantum well. The large electron effective mass in this system allows us to reach very large values of the interaction parameter [Formula: see text], defined as the ratio of the Coulomb to Fermi energies. As we lower the electron density via gate bias, we find a sequence of phases, qualitatively consistent with the above scenario: a paramagnetic phase at large densities, a spontaneous transition to a ferromagnetic state when [Formula: see text] surpasses 35, and then a phase with strongly nonlinear current-voltage characteristics, suggestive of a pinned Wigner solid, when [Formula: see text] exceeds [Formula: see text] However, our sample makes a transition to an insulating state at [Formula: see text], preceding the onset of the spontaneous ferromagnetism, implying that besides interaction, the role of disorder must also be taken into account in understanding the different phases of a realistic dilute electron system.

2.
N Engl J Med ; 380(19): 1804-1814, 2019 05 09.
Artículo en Inglés | MEDLINE | ID: mdl-31067370

RESUMEN

BACKGROUND: Nipah virus is a highly virulent zoonotic pathogen that can be transmitted between humans. Understanding the dynamics of person-to-person transmission is key to designing effective interventions. METHODS: We used data from all Nipah virus cases identified during outbreak investigations in Bangladesh from April 2001 through April 2014 to investigate case-patient characteristics associated with onward transmission and factors associated with the risk of infection among patient contacts. RESULTS: Of 248 Nipah virus cases identified, 82 were caused by person-to-person transmission, corresponding to a reproduction number (i.e., the average number of secondary cases per case patient) of 0.33 (95% confidence interval [CI], 0.19 to 0.59). The predicted reproduction number increased with the case patient's age and was highest among patients 45 years of age or older who had difficulty breathing (1.1; 95% CI, 0.4 to 3.2). Case patients who did not have difficulty breathing infected 0.05 times as many contacts (95% CI, 0.01 to 0.3) as other case patients did. Serologic testing of 1863 asymptomatic contacts revealed no infections. Spouses of case patients were more often infected (8 of 56 [14%]) than other close family members (7 of 547 [1.3%]) or other contacts (18 of 1996 [0.9%]). The risk of infection increased with increased duration of exposure of the contacts (adjusted odds ratio for exposure of >48 hours vs. ≤1 hour, 13; 95% CI, 2.6 to 62) and with exposure to body fluids (adjusted odds ratio, 4.3; 95% CI, 1.6 to 11). CONCLUSIONS: Increasing age and respiratory symptoms were indicators of infectivity of Nipah virus. Interventions to control person-to-person transmission should aim to reduce exposure to body fluids. (Funded by the National Institutes of Health and others.).


Asunto(s)
Infecciones por Henipavirus/transmisión , Virus Nipah , Adolescente , Adulto , Factores de Edad , Animales , Bangladesh/epidemiología , Líquidos Corporales/virología , Niño , Trazado de Contacto , Transmisión de Enfermedad Infecciosa/prevención & control , Femenino , Infecciones por Henipavirus/epidemiología , Infecciones por Henipavirus/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto Joven , Zoonosis/transmisión
3.
J Infect Dis ; 222(3): 438-442, 2020 07 06.
Artículo en Inglés | MEDLINE | ID: mdl-32115627

RESUMEN

Contact patterns play a key role in disease transmission, and variation in contacts during the course of illness can influence transmission, particularly when accompanied by changes in host infectiousness. We used surveys among 1642 contacts of 94 Nipah virus case patients in Bangladesh to determine how contact patterns (physical and with bodily fluids) changed as disease progressed in severity. The number of contacts increased with severity and, for case patients who died, peaked on the day of death. Given transmission has only been observed among fatal cases of Nipah virus infection, our findings suggest that changes in contact patterns during illness contribute to risk of infection.


Asunto(s)
Líquidos Corporales/virología , Trazado de Contacto/estadística & datos numéricos , Infecciones por Henipavirus/transmisión , Virus Nipah , Conducta Social , Adolescente , Adulto , Bangladesh/epidemiología , Progresión de la Enfermedad , Transmisión de Enfermedad Infecciosa/prevención & control , Femenino , Infecciones por Henipavirus/epidemiología , Infecciones por Henipavirus/prevención & control , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Adulto Joven
4.
J Infect Dis ; 221(Suppl 4): S363-S369, 2020 05 11.
Artículo en Inglés | MEDLINE | ID: mdl-32392322

RESUMEN

It is of uttermost importance that the global health community develops the surveillance capability to effectively monitor emerging zoonotic pathogens that constitute a major and evolving threat for human health. In this study, we propose a comprehensive framework to measure changes in (1) spillover risk, (2) interhuman transmission, and (3) morbidity/mortality associated with infections based on 6 epidemiological key indicators derived from routine surveillance. We demonstrate the indicators' value for the retrospective or real-time assessment of changes in transmission and epidemiological characteristics using data collected through a long-standing, systematic, hospital-based surveillance system for Nipah virus in Bangladesh. We show that although interhuman transmission and morbidity/mortality indicators were stable, the number and geographic extent of spillovers varied significantly over time. This combination of systematic surveillance and active tracking of transmission and epidemiological indicators should be applied to other high-risk emerging pathogens to prevent public health emergencies.


Asunto(s)
Enfermedades Transmisibles Emergentes/virología , Infecciones por Henipavirus/transmisión , Infecciones por Henipavirus/virología , Virus Nipah/aislamiento & purificación , Animales , Bangladesh/epidemiología , Análisis por Conglomerados , Infecciones por Henipavirus/epidemiología , Humanos , Modelos Biológicos , Factores de Riesgo , Zoonosis
5.
Parasitol Res ; 119(1): 339-344, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31734864

RESUMEN

We present the first recognized case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in a 15-year-old male from Bangladesh. He performed daily nasal rinsing with untreated ground water and bathed in untreated ground water or river water, which likely exposed him to N. fowleri.


Asunto(s)
Infecciones Protozoarias del Sistema Nervioso Central/parasitología , Naegleria fowleri/aislamiento & purificación , Adolescente , Animales , Bangladesh , Resultado Fatal , Agua Dulce/parasitología , Humanos , Masculino
6.
Clin Infect Dis ; 69(Suppl 4): S262-S273, 2019 10 09.
Artículo en Inglés | MEDLINE | ID: mdl-31598664

RESUMEN

Despite reductions over the past 2 decades, childhood mortality remains high in low- and middle-income countries in sub-Saharan Africa and South Asia. In these settings, children often die at home, without contact with the health system, and are neither accounted for, nor attributed with a cause of death. In addition, when cause of death determinations occur, they often use nonspecific methods. Consequently, findings from models currently utilized to build national and global estimates of causes of death are associated with substantial uncertainty. Higher-quality data would enable stakeholders to effectively target interventions for the leading causes of childhood mortality, a critical component to achieving the Sustainable Development Goals by eliminating preventable perinatal and childhood deaths. The Child Health and Mortality Prevention Surveillance (CHAMPS) Network tracks the causes of under-5 mortality and stillbirths at sites in sub-Saharan Africa and South Asia through comprehensive mortality surveillance, utilizing minimally invasive tissue sampling (MITS), postmortem laboratory and pathology testing, verbal autopsy, and clinical and demographic data. CHAMPS sites have established facility- and community-based mortality notification systems, which aim to report potentially eligible deaths, defined as under-5 deaths and stillbirths within a defined catchment area, within 24-36 hours so that MITS can be conducted quickly after death. Where MITS has been conducted, a final cause of death is determined by an expert review panel. Data on cause of death will be provided to local, national, and global stakeholders to inform strategies to reduce perinatal and childhood mortality in sub-Saharan Africa and South Asia.


Asunto(s)
Causas de Muerte/tendencias , Salud Infantil/tendencias , Mortalidad del Niño/tendencias , África del Sur del Sahara/epidemiología , Asia/epidemiología , Autopsia/tendencias , Niño , Salud Global/tendencias , Humanos , Vigilancia de la Población/métodos , Mortinato/epidemiología
7.
J Infect Dis ; 217(9): 1390-1394, 2018 04 11.
Artículo en Inglés | MEDLINE | ID: mdl-29351657

RESUMEN

Nipah virus is a zoonotic virus harbored by bats and lethal to humans. Bat-to-human spillovers occur every winter in Bangladesh. However, there is significant heterogeneity in the number of spillovers detected by district and year that remains unexplained. We analyzed data from all 57 spillovers during 2007-2013 and found that temperature differences explained 36% of the year-to-year variation in the total number of spillovers each winter and that distance to surveillance hospitals explained 45% of spatial heterogeneity. Interventions to prevent human infections may be most important during colder winters. Further work is needed to understand how dynamics of bat infections explains spillover risk.


Asunto(s)
Brotes de Enfermedades/veterinaria , Infecciones por Henipavirus/veterinaria , Virus Nipah , Estaciones del Año , Zoonosis/virología , Animales , Bangladesh/epidemiología , Quirópteros/virología , Infecciones por Henipavirus/virología , Humanos , Estudios Retrospectivos , Factores de Tiempo , Zoonosis/epidemiología
8.
Emerg Infect Dis ; 24(1): 15-21, 2018 01.
Artículo en Inglés | MEDLINE | ID: mdl-29260663

RESUMEN

Nipah virus (NiV) has been transmitted from patient to caregivers in Bangladesh presumably through oral secretions. We aimed to detect whether NiV-infected patients contaminate hospital surfaces with the virus. During December 2013-April 2014, we collected 1 swab sample from 5 surfaces near NiV-infected patients and tested surface and oral swab samples by real-time reverse transcription PCR for NiV RNA. We identified 16 Nipah patients; 12 cases were laboratory-confirmed and 4 probable. Of the 12 laboratory-confirmed cases, 10 showed NiV RNA in oral swab specimens. We obtained surface swab samples for 6 Nipah patients; 5 had evidence of NiV RNA on >1 surface: 4 patients contaminated towels, 3 bed sheets, and 1 the bed rail. Patients with NiV RNA in oral swab samples were significantly more likely than other Nipah patients to die. To reduce the risk for fomite transmission of NiV, infection control should target hospital surfaces.


Asunto(s)
Contaminación de Equipos , Infecciones por Henipavirus/epidemiología , Infecciones por Henipavirus/virología , Hospitales , Virus Nipah/aislamiento & purificación , Bangladesh/epidemiología , Ropa de Cama y Ropa Blanca/virología , Lechos/virología , Brotes de Enfermedades , Fómites , Infecciones por Henipavirus/mortalidad , Humanos , Control de Infecciones/métodos , Boca/virología , ARN Viral/aislamiento & purificación
9.
Emerg Infect Dis ; 23(9): 1446-1453, 2017 09.
Artículo en Inglés | MEDLINE | ID: mdl-28820130

RESUMEN

Preventing emergence of new zoonotic viruses depends on understanding determinants for human risk. Nipah virus (NiV) is a lethal zoonotic pathogen that has spilled over from bats into human populations, with limited person-to-person transmission. We examined ecologic and human behavioral drivers of geographic variation for risk of NiV infection in Bangladesh. We visited 60 villages during 2011-2013 where cases of infection with NiV were identified and 147 control villages. We compared case villages with control villages for most likely drivers for risk of infection, including number of bats, persons, and date palm sap trees, and human date palm sap consumption behavior. Case villages were similar to control villages in many ways, including number of bats, persons, and date palm sap trees, but had a higher proportion of households in which someone drank sap. Reducing human consumption of sap could reduce virus transmission and risk for emergence of a more highly transmissible NiV strain.


Asunto(s)
Quirópteros/virología , Brotes de Enfermedades , Infecciones por Henipavirus/transmisión , Virus Nipah/aislamiento & purificación , Zoonosis/transmisión , Animales , Bangladesh/epidemiología , Estudios de Casos y Controles , Conducta Alimentaria/etnología , Infecciones por Henipavirus/epidemiología , Infecciones por Henipavirus/etnología , Infecciones por Henipavirus/virología , Humanos , Virus Nipah/patogenicidad , Virus Nipah/fisiología , Phoeniceae , Riesgo , Población Rural , Zoonosis/epidemiología , Zoonosis/virología
10.
Clin Rehabil ; 31(6): 781-789, 2017 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-27311454

RESUMEN

OBJECTIVES: To explore the feasibility of conducting a full trial designed to determine the effectiveness of a model of community-based care for people with spinal cord injury in Bangladesh. STUDY DESIGN: A pilot randomised trial. SETTING: Community, Bangladesh. SUBJECTS: Participants were 30 people with recent spinal cord injury who were wheelchair-dependent and soon to be discharged from hospital. INTERVENTION: Participants randomised to the intervention group received a package of care involving regular telephone contact and three home visits over two years. Participants randomised to the control group received usual care consisting of a telephone call and an optional home visit. MAIN MEASURES: Participants were assessed at baseline and two years after randomization. The primary outcome was mortality and secondary outcomes were measures of complications, depression, participation and quality of life. RESULTS: A total of 24 participants had a complete spinal cord injury and six participants had an incomplete spinal cord injury. Median (interquartile) age and time since injury at baseline were 31 years (24 to 36) and 7 months (4 to 13), respectively. Two participants, one in each group, died. Five participants had pressure ulcers at two years. There were no notable impediments to the conduct of the trial and no significant protocol violations. The phone calls and home visits were delivered according to the protocol 87% and 100% of the time, respectively. Follow-up data were 99% complete. CONCLUSION: This pilot trial demonstrates the feasibility of a full clinical trial of 410 participants, which has recently commenced. SPONSORSHIP: University of Sydney, Australia.


Asunto(s)
Servicios de Salud Comunitaria/organización & administración , Continuidad de la Atención al Paciente/tendencias , Evaluación de la Discapacidad , Traumatismos de la Médula Espinal/rehabilitación , Adulto , Bangladesh , Continuidad de la Atención al Paciente/economía , Países en Desarrollo , Estudios de Seguimiento , Visita Domiciliaria/estadística & datos numéricos , Humanos , Puntaje de Gravedad del Traumatismo , Masculino , Alta del Paciente , Proyectos Piloto , Medición de Riesgo , Factores Socioeconómicos , Traumatismos de la Médula Espinal/diagnóstico , Traumatismos de la Médula Espinal/mortalidad , Tasa de Supervivencia , Silla de Ruedas/estadística & datos numéricos , Adulto Joven
11.
Spinal Cord ; 55(12): 1071-1078, 2017 12.
Artículo en Inglés | MEDLINE | ID: mdl-28809389

RESUMEN

OBJECTIVE: To determine from a societal perspective the cost-effectiveness and cost-utility of telephone-based support for management of pressure ulcers. STUDY DESIGN: Cost-effectiveness and cost-utility analysis of a randomised clinical trial. SETTING: Tertiary centre in India and Bangladesh. METHODS: An economic evaluation was conducted alongside a randomised clinical trial comparing 12 weeks of telephone-based support (intervention group) with usual care (control group). The analyses evaluated costs and health outcomes in terms of cm2 reduction of pressure ulcers size and quality-adjusted life years (QALYs) gained. All costs were in Indian Rupees (INR) and then converted to US dollars (USD). RESULTS: The mean (95% confidence interval) between-group difference for the reduction in size of pressure ulcers was 0.53 (-3.12 to 4.32) cm2, favouring the intervention group. The corresponding QALYs were 0.027 (0.004-0.051), favouring the intervention group. The mean total cost per participant in the intervention group was INR 43 781 (USD 2460) compared to INR 42 561 (USD 2391) for the control group. The per participant cost of delivering the intervention was INR 2110 (USD 119). The incremental cost-effectiveness ratio was INR 2306 (USD 130) per additional cm2 reduction in the size of the pressure ulcer and INR 44 915 (USD 2523) per QALY gained. CONCLUSION: In terms of QALYs, telephone-based support to help people manage pressure ulcers at home provides good value for money and has an 87% probability of being cost-effective, based on 3 times gross domestic product. Sensitivity analyses were performed using the overall cost data with and without productivity costs, and did not alter this conclusion.


Asunto(s)
Úlcera por Presión/economía , Úlcera por Presión/terapia , Traumatismos de la Médula Espinal/economía , Traumatismos de la Médula Espinal/terapia , Telemedicina/economía , Adulto , Bangladesh , Análisis Costo-Beneficio , Femenino , Humanos , India , Masculino , Úlcera por Presión/etiología , Probabilidad , Años de Vida Ajustados por Calidad de Vida , Método Simple Ciego , Traumatismos de la Médula Espinal/complicaciones , Teléfono , Resultado del Tratamiento
12.
Mymensingh Med J ; 26(1): 17-20, 2017 01.
Artículo en Inglés | MEDLINE | ID: mdl-28260750

RESUMEN

This case-control study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2015 to December 2015. The aim of the study was to explore the serum zinc status among acute myocardial infarction (AMI) patients as a means to monitor the possibility of management of these patients. A total of 120 subjects were included in this study. Among them 60 were diagnosed AMI patients denoted as case group and 60 were normal healthy individuals denoted as control group. Serum zinc was determined by colorimetric method from each sample. Statistical analysis was performed by SPSS windows package, version 20. Among the study groups the Mean±SD values of serum zinc were 64.98±18.86µmol/L and 97.14±7.97µmol/L in case and control group respectively. Analysis showed that the mean serum zinc level was significantly (p<0.01) decreased in AMI patients in comparison to that of control group.


Asunto(s)
Infarto del Miocardio , Zinc , Bangladesh , Estudios de Casos y Controles , Humanos , Masculino , Infarto del Miocardio/sangre , Zinc/sangre
13.
Mymensingh Med J ; 26(2): 395-405, 2017 04.
Artículo en Inglés | MEDLINE | ID: mdl-28588178

RESUMEN

This study was aimed at finding the parameters for prediction of difficulty in endotracheal intubation, that are easy to examine and that could better predict difficulty. The current observational prospective, cross sectional study was conducted in the department of Anaesthesia, Analgesia and Intensive Care Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2015 to September 2015 comprising 180 patient of both sexes requiring endotracheal intubation were arranged into two groups, Group A: Modified Mallampati test Group and Group B: Modified Mallampati & upper lip bite test group (combined) Assessment of difficulty in intubation was done by Cormack & Lehane direct Laryngoscopic grading. Outcome was measured as no difficulty or difficulty in intubation. In Group A 33 cases were true positive, 15 false negative, 26 false positive, 16 true negative. In Group B 53 cases were true positive, 1 false positive, 8 false negative, 28 true negative. The validity tests for Group A for evaluation of difficult intubation were indicated by sensitivity 55.9%, Specificity 51.6%, Accuracy 54.41%, Positive predictive value 68.8% and Negative predictive value 38.1%. The values for Group-B were 86.9%, 96.6%, 90.0%, 98.1% and 77.8% respectively. Combined modified Mallampati & Upper Lip Bite Test has definite value in the diagnosis of difficulty in intubation and can be regarded as sensitive & specific test for operative discrimination of the patient.


Asunto(s)
Fuerza de la Mordida , Intubación Intratraqueal , Bangladesh , Estudios Transversales , Femenino , Humanos , Intubación Intratraqueal/métodos , Laringoscopía , Labio , Masculino , Estudios Prospectivos
14.
Mymensingh Med J ; 26(1): 37-44, 2017 01.
Artículo en Inglés | MEDLINE | ID: mdl-28260753

RESUMEN

Infections caused by Staphylococcus aureus were treated by methicillin, but about 95% of S. aureus has been resistance to methicillin, both in the community and hospitals and are increasing day by day. MRSA produces altered penicillin binding protein, PBP2a, due to the expression of mecA gene. Some strains of both the MRSA and MSSA carry PVL gene. This cross sectional observational study was conducted to detect the molecular-characterization of methicillin resistant Staphylococcus aureus (MRSA) and carried out in the Department of Microbiology, Mymensingh Medical College from July 2014 to December 2015. Clinical samples for this study were wound swab, pus, exudates from diabetic ulcer and burn ulcer, aural swab, blood and urine which were collected from three tertiary care hospitals such as from MMCH, BIRDEM hospital and SSMCH. Standard microbiological procedure & biochemical tests were carried out to detect S. aureus. Oxacillin disk diffusion method (ODDM) was done by Kirby-Bauer disk diffusion method. Out of a total 109 culture positive samples 69 isolates of S. aureus were selected for the study. Among the 69 isolates 33, 27 and 09 were from MMCH, BIRDEM hospital and SSMCH respectively. Among the 69 isolates, 17(24.6%) and 52(75.3%) were distinguished as MRSA and MSSA respectively by ODDM. In contrast, detection of presence and absence of mecA gene by PCR identified 20(28.9%) and 49(71.01%) isolates as MRSA and MSSA respectively. Multiplex PCR was performed by standard protocol with specific primers for detection of 16S rRNA gene for Staphylococcus, nuc gene for Staphylococcus aureus, mecA gene for MRSA, PVL gene as a virulence factor and ACME-arc gene for worldwide spreading USA 300 MRSA clone. The PVL gene were detected in 3 out of 20 MRSA (15%) and 19 out of 49 MSSA (38.7%) and the ACME- arc gene was not found in any isolates. All of the S. aureus (MRSA and MSSA) isolates were sensitive to Vancomycin and Gentamicin. All MRSA isolates (100%) showed resistance to Penicillin and Oxacillin. Of the MRSA isolates about 88.2% were resistance to Ceftazidime, 64.7% were resistance to Erythromycin and Ciprofloxacin, 11.7% were resistance to Tetracycline. Among the MSSA isolates 94.2% were resistance to Penicillin and 9.6% resistance to Ciprofloxacin. The MSSA were less resistance for non-beta lactam drugs than MRSA.


Asunto(s)
Antibacterianos , Staphylococcus aureus Resistente a Meticilina , Meticilina , Infecciones Estafilocócicas , Centros de Atención Terciaria , Antibacterianos/uso terapéutico , Proteínas Bacterianas , Bangladesh , Estudios Transversales , Humanos , Meticilina/uso terapéutico , Staphylococcus aureus Resistente a Meticilina/efectos de los fármacos , Staphylococcus aureus Resistente a Meticilina/genética , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Pruebas de Sensibilidad Microbiana , ARN Ribosómico 16S , Staphylococcus aureus
15.
Emerg Infect Dis ; 22(4): 664-70, 2016 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-26981928

RESUMEN

Nipah virus (NiV) is a paramyxovirus, and Pteropus spp. bats are the natural reservoir. From December 2010 through March 2014, hospital-based encephalitis surveillance in Bangladesh identified 18 clusters of NiV infection. The source of infection for case-patients in 3 clusters in 2 districts was unknown. A team of epidemiologists and anthropologists investigated these 3 clusters comprising 14 case-patients, 8 of whom died. Among the 14 case-patients, 8 drank fermented date palm sap (tari) regularly before their illness, and 6 provided care to a person infected with NiV. The process of preparing date palm trees for tari production was similar to the process of collecting date palm sap for fresh consumption. Bat excreta was reportedly found inside pots used to make tari. These findings suggest that drinking tari is a potential pathway of NiV transmission. Interventions that prevent bat access to date palm sap might prevent tari-associated NiV infection.


Asunto(s)
Bebidas Alcohólicas/virología , Quirópteros/virología , Brotes de Enfermedades , Reservorios de Enfermedades/virología , Encefalitis Viral/transmisión , Infecciones por Henipavirus/transmisión , Virus Nipah/patogenicidad , Adolescente , Adulto , Anciano , Consumo de Bebidas Alcohólicas/efectos adversos , Bebidas Alcohólicas/efectos adversos , Animales , Anticuerpos Antivirales/sangre , Bangladesh/epidemiología , Niño , Preescolar , Encefalitis Viral/etiología , Encefalitis Viral/mortalidad , Encefalitis Viral/virología , Monitoreo Epidemiológico , Heces/virología , Infecciones por Henipavirus/etiología , Infecciones por Henipavirus/mortalidad , Infecciones por Henipavirus/virología , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Lactante , Persona de Mediana Edad , Virus Nipah/genética , Virus Nipah/aislamiento & purificación , Análisis de Supervivencia
16.
BMC Public Health ; 16: 726, 2016 08 05.
Artículo en Inglés | MEDLINE | ID: mdl-27495927

RESUMEN

BACKGROUND: During a fatal Nipah virus (NiV) outbreak in Bangladesh, residents rejected biomedical explanations of NiV transmission and treatment and lost trust in the public healthcare system. Field anthropologists developed and communicated a prevention strategy to bridge the gap between the biomedical and local explanation of the outbreak. METHODS: We explored residents' beliefs and perceptions about the illness and care-seeking practices and explained prevention messages following an interactive strategy with the aid of photos showed the types of contact that can lead to NiV transmission from bats to humans by drinking raw date palm sap and from person-to-person. RESULTS: The residents initially believed that the outbreak was caused by supernatural forces and continued drinking raw date palm sap despite messages from local health authorities to stop. Participants in community meetings stated that the initial messages did not explain that bats were the source of this virus. After our intervention, participants responded that they now understood how NiV could be transmitted and would abstain from raw sap consumption and maintain safer behaviours while caring for patients. CONCLUSIONS: During outbreaks, one-way behaviour change communication without meaningful causal explanations is unlikely to be effective. Based on the cultural context, interactive communication strategies in lay language with supporting evidence can make biomedical prevention messages credible in affected communities, even among those who initially invoke supernatural causal explanations.


Asunto(s)
Quirópteros/virología , Brotes de Enfermedades , Ingestión de Líquidos , Comunicación en Salud , Infecciones por Henipavirus/prevención & control , Virus Nipah , Exudados de Plantas , Animales , Bangladesh/epidemiología , Causalidad , Control de Enfermedades Transmisibles , Cultura , Conducta Alimentaria , Conductas Relacionadas con la Salud , Conocimientos, Actitudes y Práctica en Salud , Infecciones por Henipavirus/epidemiología , Humanos , Phoeniceae , Exudados de Plantas/efectos adversos , Exudados de Plantas/química , Práctica de Salud Pública , Características de la Residencia
17.
Spinal Cord ; 54(6): 483-9, 2016 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-26458967

RESUMEN

STUDY DESIGN: Mixed retrospective-prospective cohort study. OBJECTIVES: To determine psychological and socioeconomic status, complications and quality of life in people with spinal cord injuries (SCI) after discharge from a hospital in Bangladesh. SETTING: Bangladesh. METHODS: All patients admitted in 2011 with a recent SCI to a hospital in Bangladesh were identified. Patients were interviewed by telephone in 2014 using translated versions of the SF12, the SCI Secondary Conditions Scale, the Centre for Epidemiologic Studies Depression Scale (CESDS) and the Participation Component of the WHODAS. Questions were also asked about employment, living and financial situation, and opportunities to get out of bed and out of the house. Data were stratified by ability to walk on discharge. RESULTS: A total of 350 people were discharged with a recent SCI in 2011. By 2014, 55 had died. Of those still living, 283 were interviewed (96% follow-up rate). At the time of interview, 47% of participants were employed. One-quarter (26%) of those who were wheelchair-dependent had a pressure ulcer. The mean (s.d.) scores for the Mental and Physical Component of the SF12 were 32.0 points (5.5) and 35.8 points (3.9), respectively. The median (interquartile range) scores for the SCI Secondary Conditions Scale, CESDS and WHODAS for those who were wheelchair-dependent were 15% (10 to 19), 11 points (9 to 18) and 26 points (23 to 26), respectively. CONCLUSION: Many people with SCI in Bangladesh are house-bound, unemployed, living in poverty and have pressure ulcers. They experience moderate rates of depression and report limited quality of life.


Asunto(s)
Empleo , Estados Financieros , Trastornos del Humor/etiología , Alta del Paciente/estadística & datos numéricos , Calidad de Vida/psicología , Traumatismos de la Médula Espinal/complicaciones , Traumatismos de la Médula Espinal/psicología , Adulto , Bangladesh , Estudios de Cohortes , Evaluación de la Discapacidad , Femenino , Humanos , Masculino , Úlcera por Presión/etiología , Traumatismos de la Médula Espinal/epidemiología , Silla de Ruedas , Adulto Joven
18.
Spinal Cord ; 54(2): 132-6, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26078229

RESUMEN

STUDY DESIGN: Mixed retrospective-prospective cohort study. OBJECTIVES: To determine 2-year survival following discharge from hospital after spinal cord injury in Bangladesh. SETTING: Bangladesh. METHODS: Medical records were used to identify all patients admitted in 2011 with a recent spinal cord injury to the Centre for Rehabilitation of the Paralysed, a large Bangladeshi hospital that specialises in care of people with spinal cord injury. Patients or their families were subsequently visited or contacted by telephone in 2014. Vital status and, where relevant, date and cause of death were determined by verbal autopsy. RESULTS: 350 of 371 people admitted with a recent spinal cord injury in 2011 were discharged alive from hospital. All but eleven were accounted for two years after discharge (97% follow-up). Two-year survival was 87% (95% CI 83% to 90%). Two-year survival of those who were wheelchair-dependent was 81% (95% CI 76% to 86%). The most common cause of death was sepsis due to pressure ulcers. CONCLUSION: In Bangladesh, approximately one in five people with spinal cord injury who are wheelchair-dependent die within two years of discharge from hospital. Most deaths are due to sepsis from potentially preventable pressure ulcers.


Asunto(s)
Alta del Paciente/estadística & datos numéricos , Úlcera por Presión/mortalidad , Sepsis/mortalidad , Traumatismos de la Médula Espinal/mortalidad , Traumatismos de la Médula Espinal/terapia , Silla de Ruedas/estadística & datos numéricos , Adulto , Bangladesh/epidemiología , Causalidad , Comorbilidad , Femenino , Estudios de Seguimiento , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Prevalencia , Factores de Riesgo , Tasa de Supervivencia , Resultado del Tratamiento
19.
Mymensingh Med J ; 25(4): 611-614, 2016 10.
Artículo en Inglés | MEDLINE | ID: mdl-27941718

RESUMEN

This case control study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Cardiology, Mymensingh Medical College Hospital, Mymensingh, Bangladesh from January 2015 to December 2015. The aim of the study was to explore the serum copper status among acute myocardial infarction (AMI) patients as a means to monitor the possibility of management of these patients. A total of 120 subjects were included in this study. Among them 60 were diagnosed AMI patients denoted as case group and 60 were normal healthy individuals denoted as control group. Serum copper determined by colorimetric method from each sample. Statistical analysis was performed by SPSS windows package, version 20. Among the study groups the mean serum copper levels were 150.30±26.16 and 103.65±9.38 in case and control group respectively. Analysis showed that the mean serum copper level was significantly (p<0.01) increased in AMI patients in comparison to that of control group.


Asunto(s)
Infarto del Miocardio , Bangladesh , Estudios de Casos y Controles , Cobre , Humanos , Masculino
20.
Mymensingh Med J ; 25(3): 450-7, 2016 07.
Artículo en Inglés | MEDLINE | ID: mdl-27612890

RESUMEN

The aim of this study was to detect antimicrobial susceptibilities and the presence of drug resistance genes of MRSA from tertiary care hospitals. This study was carried out in the Department of Microbiology, Mymensingh Medical College during the period from Jan, 2015 to Dec, 2015. Clinical samples, including wound swab, pus, exudates from diabetic ulcer and burn ulcer, aural swab, blood and urine were collected. Standard microbiological procedure & biochemical tests were carried out to detect S. aureus. Oxacillin disk diffusion test was done by Kirby-Bauer disk diffusion method. Total 69 isolates of S. aureus were selected for the study. The isolates were collected from three different tertiary care hospitals, of which 33, 27 and 9 were from Mymensingh Medical College Hospital (MMCH), BIRDEM hospital and Sir Salimullah Medical College Hospital (SSMCH) respectively. Among the 69 isolates, 17(24.6%) and 52(75.3%) were distinguished as MRSA and MSSA respectively by ODDM (Oxacillin disk diffusion method). In contrast, detection of presence and absence of mecA gene by PCR identified 20 (28.9%) and 49 (71.01%) isolates as MRSA and MSSA respectively. All of the S. aureus (MRSA and MSSA) isolates were sensitive to vancomycin and gentamicin. All MRSA isolates (100%) showed resistance to Penicillin and Oxacillin. Among the MRSA isolates about 88.2% were resistance to Ceftazidime, 64.7% were resistance to Erythromycin and Ciprofloxacin, 11.7% were resistance to Tetracycline. Among the MSSA isolates about 94.2% were resistance to Penicillin and 9.6% resistance to Ciprofloxacin. The MSSA were less resistance for non-beta lactam drugs than MRSA. Regarding drug resistance genes, the blaZ genes were present in 47 out of 49(95.8%) MSSA and in 18 out of 18 (100%) MRSA. The erythromycin resistance gene ermB was found in 8.69% isolates, of which highest 20% in MRSA and 4.08% in MSSA. The ermA was not found in any isolates. Among tetracycline resistance genes, tetK were detected in 10.1% and tetL were found in 2.8% of MRSA. The highest tetK genes were found in 20% of MRSA and in 6.1% of MSSA. Regarding, the gentamicin drug resistance, the aac(6')-Iaph(2'')-Ia gene was not found in any isolates. The relatively high proportion of MRSA and the associated antibiotic resistance seen in this study emphasizes the need for country based surveillance to characterize and monitor MRSA and to develop strategies that will improve MRSA treatment and control.


Asunto(s)
Antiinfecciosos , Staphylococcus aureus Resistente a Meticilina , Meticilina , Infecciones Estafilocócicas , Antibacterianos , Antiinfecciosos/farmacología , Proteínas Bacterianas , Bangladesh , Humanos , Meticilina/farmacología , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Pruebas de Sensibilidad Microbiana , Infecciones Estafilocócicas/tratamiento farmacológico , Centros de Atención Terciaria
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