Trajectories and impact of White mentors' beliefs about racial and ethnic discrimination in a formal youth mentoring program.

To examine associations between White mentors' beliefs regarding the presence of discrimination towards Black, Indigenous, and people of Color (BIPOC) individuals and mentoring relationship outcomes, mentors' beliefs about racial/ethnic discrimination were assessed before random mentee assignment and at the end of 9 months of mentoring. White mentors matched with BIPOC youth showed greater increases in beliefs that discrimination limits opportunities for Black Americans. Stronger endorsement of the impacts of discrimination for Hispanic Americans resulted in less youth relationship anxiety when White mentors were matched with White mentees, but not when they were matched with BIPOC mentees. Last, greater increases in beliefs that discrimination limits opportunities for Black Americans resulted in less relationship anxiety for White mentors matched with White mentees, but more relationship anxiety for those matched with BIPOC mentees. Programs should assess and address mentors' racial biases to minimize harm and augment the impact of mentoring programs for all youth.

A Preliminary Investigation into the Factor Structure of Two Psychological Flexibility Measures in a Sample of Community-Dwelling Older Adults.

OBJECTIVES: Acceptance and Commitment Therapy (ACT) targets psychological flexibility and the ability to identify behavioral function in context. Properly measuring these constructs is imperative to understanding whether these processes are mechanisms of change in treatment. The current study examined the factor structure of the Comprehensive Assessment of ACT processes (CompACT) and Tacting of Function scale (TOF) in community-dwelling older adults. METHODS: Factor structure was examined with CFA. Eighty community-dwelling older adults completed questionnaires prior to an intervention. RESULTS: While the original 23-item, 3-factor structure of the CompACT demonstrated inadequate fit, a modified 15-item, 3-factor structure demonstrated adequate fit. The original 1-factor structure of the TOF demonstrated inadequate fit. A modified 2-factor structure of the TOF fit significantly better than the original 1-factor structure; however, this model also demonstrated inadequate fit. CONCLUSIONS: Examining the factor structure of the CompACT and TOF in an older adult sample contributes to the field's understanding of the constructs of psychological flexibility and tacting ability and to the clinical utility of these measures in an understudied sample. CLINICAL IMPLICATIONS: These findings provide preliminary support for the use of a short-form version of the CompACT to measure therapeutic processes of change in community-dwelling older adults.

Physiological changes and symptoms associated with short-term exposure to electromagnetic fields: a randomized crossover provocation study.

BACKGROUND: The biological association between electromagnetic fields (EMF) and idiopathic environmental intolerance attributed to EMF (IEI-EMF) has not been established. To assess the physiological changes and symptoms associated with exposure to EMF, we conducted a randomized crossover provocation study. METHODS: We recruited 58 individuals with IEI-EMF (IEI-EMF group) and 92 individuals without IEI-EMF (control group). In a controlled environment, all participants received EMF signals mimicking those from mobile phone base stations in a randomized sequence under the blinded condition. During the course, participants reported their symptoms and whether they perceived EMF, and we monitored their physiological parameters, including blood pressure (BP), heart rate (HR), and HR variability. RESULTS: The IEI-EMF and control groups reported similar frequencies of symptoms during both the provocation and sham sessions. No participant could accurately identify the provocation. In both groups, physiological parameters were similar between the two sessions. The control group, but not the IEI-EMF group, had elevated HR when they perceived EMF exposure. CONCLUSIONS: No symptoms or changes in physiological parameters were found to be associated with short-term exposure to EMF, and no participant could accurately detect the presence of EMF. Moreover, the participants in the control group, but not those in the IEI-EMF group, had elevated HR when they perceived EMF.

A Cross-Cultural Examination of the Role of Youth Emotion Regulation in Mentoring Relationships.

Youth mentoring programs have grown in popularity, both within the United States (U.S.) and abroad, as an intervention to support youth with common behavioral and emotional difficulties. However, it is unclear whether certain dimensions of youth risk may diminish the positive impact of formalized mentoring relationships. The current study therefore examined whether youth emotion regulation, a transdiagnostic risk factor for both externalizing and internalizing behavioral difficulties, predicted mentoring relationship quality and the likelihood of early match closure. Participants included 1,298 randomized mentor-youth dyads from two nationwide mentoring programs, one with chapters across the U.S. (youth: 56% female; 37% White), and another with chapters across Mexico (youth: 49% female; 100% non-Indigenous). At baseline, youth completed the Emotion Regulation Questionnaire for Children and Adolescents (ERQ-CA). At program completion, youth and mentors completed measures of mentoring relationship quality. Multigroup structural equation models of youth outcomes revealed that greater youth use of cognitive reappraisal predicted better mentoring relationship quality in both countries when co-varying for sex, and that this relationship was stronger for mentor-youth pairs in the U.S. compared to those in Mexico. These findings have important implications for understanding the ways in which youth characteristics might shape the quality and impact of mentoring relationships across different cultural settings.

An Online Rail Track Fastener Classification System Based on YOLO Models.

In order to save manpower on rail track inspection, computer vision-based methodologies are developed. We propose utilizing the YOLOv4-Tiny neural network to identify track defects in real time. There are ten defects covering fasteners, rail surfaces, and sleepers from the upward and six defects about the rail waist from the sideward. The proposed real-time inspection system includes a high-performance notebook, two sports cameras, and three parallel processes. The hardware is mounted on a flat cart running at 30 km/h. The inspection results about the abnormal track components could be queried by defective type, time, and the rail hectometer stake. In the experiments, data augmentation by a Cycle Generative Adversarial Network (GAN) is used to increase the dataset. The number of images is 3800 on the upward and 967 on the sideward. Five object detection neural network models-YOLOv4, YOLOv4-Tiny, YOLOX-Tiny, SSD512, and SSD300-were tested. The YOLOv4-Tiny model with 150 FPS is selected as the recognition kernel, as it achieved 91.7%, 92%, and 91% for the mAP, precision, and recall of the defective track components from the upward, respectively. The mAP, precision, and recall of the defective track components from the sideward are 99.16%, 96%, and 94%, respectively.

Mindfulness, depression, and emotional eating: The moderating role of nonjudging of inner experience.

Emotional eating is defined as the tendency to increase food consumption in order to modify negative emotional states. Theories on emotional eating attribute its cause to inadequate emotion regulation, specifically an inability to draw awareness to and accept distress. Mindfulness, or the ability to pay attention to and accept internal and external experiences, is thought to attenuate the association between internalizing distress and emotional eating. Nevertheless, there has been little research examining the moderating role of mindfulness in the relationship between psychological distress and emotional eating. The present study used a cross-sectional design to probe the effects of specific facets of mindfulness, as measured by the Five Factor Mindfulness Questionnaire, on the relationship between internalizing distress (i.e., depression and anxiety) and emotional eating in a diverse community sample (N = 248). Results showed that depression significantly interacted with nonjudging of inner experience to predict emotional eating. Those who were high in nonjudging endorsed less emotional eating than those who were average or low in nonjudging. This was significant only at low levels of depression. These findings delineate the moderating role of specific aspects of trait mindfulness in the association between depression and emotional eating and may inform more targeted intervention and prevention efforts.

Mindfulness, mood, and food: The mediating role of positive affect.

With rates of overweight and obesity rising worldwide, it is important to examine psychological factors associated with food intake. Previous research has shown that mindfulness may serve as a protective factor against overconsumption of food. Some studies have posited that mindfulness addresses unhealthy eating by promoting the increased awareness of, and decreased responsiveness to, internal emotional cues. The present study investigated the effects of a brief mindfulness induction on positive and negative affect and subsequent energy intake in a sample of undergraduate students (N = 126). After exposure to a negative mood induction, 63 participants were randomly assigned to a brief mindfulness intervention, while the remaining participants listened to a news article. Subsequently all participants were offered healthful and unhealthful snack foods. Although there was not a significant between-group difference in intake, a multiple mediation model indicated that positive affect, but not negative affect, significantly mediated the association between condition and food intake. Relative to controls, those in the experimental condition reported higher positive affect after the mindfulness induction, which in turn reduced their energy intake. Further exploratory analyses indicated that positive affect in the experimental group was associated with reduced consumption of unhealthful food. These findings provide insight into how mindfulness-based interventions may target unhealthy eating behaviors.

Effects of Natural Mentoring Relationships on College Students' Mental Health: The Role of Emotion Regulation.

The transition to college involves a number of novel stressors for young adults and represents a period of heightened risk for the onset or worsening of diverse mental health problems. The presence of natural mentors may be one factor which alleviates risk for mental health problems in college first-year students. Using a diverse sample of 275 first-year college students, the present study examined the effects of different types of natural mentors within students' support networks on internalizing symptoms during the first semester of college. In addition, analyses explored whether different student approaches to emotion regulation were one mechanism by which natural mentors influence internalizing symptoms. Path analyses indicated that students with a greater number of close family member/family friend mentors reported less emotion suppression, which in turn accounted for the associations between these mentoring relationships and reduced depressive symptoms and worry at follow-up. In contrast, less emotionally close mentors, such as teachers or coworkers, did not significantly shape emotion regulation strategies or internalizing symptom outcomes. Results have implications for the design of more targeted interventions that promote emotional well-being in college first-year students.

Bound states in the continuum in divided triangular hole metasurfaces.

We investigate the bound states in the continuum (BICs) in dielectric metasurfaces consisting of a two-part divided triangular hole in the unit cell of a square lattice, with emphasis on the generation, splitting, and merging of BICs. At the smallest height ratio between the upper triangular and the lower trapezoidal holes, the accidental BIC with an extremely large quality factor emerges on an isolated dispersion band at the Brillouin zone center, which is recognized as a polarization singularity (V point) with an integer topological charge. As the height ratio increases, the accidental BIC is split into a pair of circularly polarized states, which are polarization singularities (C points) with half-integer topological charges. The two states depart from each other to a maximum distance, and then approach each other as the height ratio continues to change. They finally merge to another polarization singularity (V point) with an integer topological charge, which is identified as the Friedrich-Wintgen BIC that occurs near the avoided crossing between two interacting dispersion bands.

A panel network analysis of posttraumatic stress disorder and obsessive-compulsive disorder symptoms across the perinatal period.

The perinatal period is marked by a higher risk of experiencing depressive, anxiety, and/or trauma-related symptoms, a phenomenon that affects millions of individuals each year. Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) symptoms commonly co-occur but have rarely been examined together beyond prevalence estimates in the perinatal period. Our study aimed to explore patterns of associations among OCD and PTSD symptoms to elucidate within- and between-person effects and how these effects may change over time. Participants (N = 270) were recruited during pregnancy from an academic medical center affiliated with a midwestern university. PTSD, OCD, and depressive symptoms were assessed at pregnancy, 4, 8, and 12 weeks postpartum. A panel graphical vector autoregression model was used to estimate networks. The temporal network provided information regarding directed predictive effects between symptoms, and hyperarousal, neutralizing, and ordering were the most stable and predictive symptoms across time. The contemporaneous network, which yields undirected partial correlations between symptoms at a given moment, indicated that there were positive associations between intrusions and avoidance, hyperarousal and negative alterations in cognitions and mood, as well as between hyperarousal and dysphoria. This study identified hyperarousal and neutralizing as the PTSD and OCD symptoms with the strongest stability, predictive power, and association with other symptoms. Clinically, this indicates that screening for hyperarousal and neutralizing symptoms may identify individuals who could maximally benefit from treatment in the perinatal period. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Confirmatory measurement modeling and longitudinal invariance of the CompACT-15: A short-form assessment of psychological flexibility.

The Comprehensive Assessment of Acceptance and Commitment Therapy Processes (CompACT; Francis et al., 2016) is a recently developed measure of psychological flexibility (PF) possessing several advantages over other measures of PF, including multidimensional assessment and relative brevity. Unfortunately, previous psychometric evaluations of the CompACT have been limited by their use of exploratory factor analysis to assess dimensionality, coefficient α to assess reliability, and a lack of attention to measurement equivalence in assessing change over time. The present study used confirmatory factor analysis (CFA) and item factor analysis (IFA) to examine the dimensionality, factor-specific reliability, longitudinal measurement invariance, and construct validity of the CompACT items in a longitudinal online sample of U.S. adults (N = 523). Converging evidence across CFA and IFA confirmatory latent variable measurement models provides support for the reduction of the 23-item CompACT to a 15-item short form with a more stable factor structure, acceptable reliability over large ranges of its three latent factors, and measurement equivalence of its items in assessing latent change over time. Results also support the construct validity of the CompACT-15 items based on its relations with theoretically relevant measures. Overall, the CompACT-15 appears to be a psychometrically sound instrument with the potential to contribute to research and intervention efforts. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

The effect of acceptance and commitment therapy on the psychological flexibility and inflexibility of undergraduate students: A systematic review and three-level meta-analysis.

Rising rates of mental health problems in undergraduate students is a critical public health issue. There is evidence supporting the efficacy of acceptance and commitment therapy (ACT) in decreasing psychological symptoms in undergraduates, which is thought to be facilitated through increases in psychological flexibility (PF) and decreases in psychological inflexibility (PIF). However, little is known about the effect of ACT on these processes in undergraduates. We conducted a systematic review and three-level meta-analysis examining this effect in 20 studies, which provided 56 effect sizes. A combined sample of 1,750 undergraduates yielded a small-to-medium overall effect (g = .38, SE = .09, p < .001, 95% CI: [0.20, 0.56]). This effect did not depend on control group type, intervention modality, number of sessions, the questionnaire used, whether PF or PIF was measured, or participant age. However, there was a significant mean effect only in studies with a specific clinical target, but not in those without one. Furthermore, the higher the percentage of female participants, the lower the reported effect size. Results suggested that ACT may increase PF and decrease PIF in undergraduates and highlighted various conceptual and measurement issues. Study protocol and materials were preregistered (https://osf.io/un6ce/).

Relationship Factors in Internet-Delivered Psychological Interventions for Veterans Experiencing Postpartum Depression: Qualitative Analysis.

BACKGROUND: Internet-delivered psychological interventions (IPIs) have been shown to be effective for a variety of psychological concerns, including postpartum depression. Human-supported programs produce better adherence and larger effect sizes than unsupported programs; however, what it is about support that affects outcomes is not well understood. Therapeutic alliance is one possibility that has been found to contribute to outcomes; however, the specific mechanism is not well understood. Participant perspectives and qualitative methodology are nearly absent from the IPI alliance research and may help provide new directions. OBJECTIVE: In this study, we aimed to provide participant perspectives on engagement with an IPI for postpartum depression to help inform alliance research, development of new IPIs, and inform resource allocation. METHODS: A qualitative methodology was used to explore participant perspectives of veteran women's engagement with the MomMoodBooster program, a human-supported internet-delivered intervention for postpartum depression. Participants were asked 4 open-ended questions with the 3-month postintervention survey, "In what ways did you find the MomMoodBooster most helpful?" "How do you think the MomMoodBooster could have been improved?" "In what ways did you find the personal coach calls to be helpful?" and "How do you think the personal coach calls could have been improved?" RESULTS: Data were collected from 184 participants who responded to at least 1 of the open-ended questions. These were analyzed using thematic analysis and a process of reaching a consensus among coders. The results suggest that not only the engagement with the support person is perceived as a significant contributor to participant experiences while using the MomMoodBooster content but also the relationship factors are particularly meaningful. The results provide insights into the specific qualities of the support person that were perceived as most impactful, such as warmth, empathy and genuineness, and feeling normalized and supported. In addition, the results provide insight into the specific change processes that can be targeted through support interactions, such as encouraging self-reflection and self-care and challenging negative thinking. CONCLUSIONS: These data emphasize the importance of relationship factors between support persons and an IPI program for postpartum depression. The findings suggest that focusing on specific aspects of the alliance and the therapeutic relationship could yield fruitful directions for the training of support personnel and for future alliance-based research of internet-delivered treatments.

Examining the Structure of Distress Tolerance: Are Behavioral and Self-Report Indicators Assessing the Same Construct?

Distress tolerance, or the ability to tolerate physically and emotionally aversive experiences, is a target of psychological intervention in contextual behavioral science. It has been conceptualized as a self-reported ability, as well as a behavioral tendency, and operationalized with a wide variability of questionnaires and behavioral tasks. The current study aimed to investigate whether behavioral tasks and self-report assessments of distress tolerance measure the same underlying dimension, two correlated dimensions, or whether method factors accounted for covariation above and beyond a general content dimension. A university student sample (N = 288) completed behavioral tasks associated with distress tolerance and self-report distress tolerance measures. Confirmatory factor analysis indicated that behavioral and self-report assessments of distress tolerance do not comprise a single dimension of distress tolerance, or two correlated dimensions of self-report or behavioral distress tolerance. Results also failed to support a bifactor conceptualization with a general distress tolerance dimension and domain-specific method dimensions for behavioral and self-report assessments. Findings suggest that more precision and attention to contextual factors are required in the operationalization and conceptualization of distress tolerance.

Application of Amyloid-Based Hybrid Membranes in Drug Delivery.

The properties of amyloid fibrils, e.g., unique structural characteristics and superior biocompatibility, make them a promising vehicle for drug delivery. Here, carboxymethyl cellulose (CMC) and whey protein isolate amyloid fibril (WPI-AF) were used to synthesize amyloid-based hybrid membranes as vehicles for the delivery of cationic and hydrophobic drugs (e.g., methylene blue (MB) and riboflavin (RF)). The CMC/WPI-AF membranes were synthesized via chemical crosslinking coupled with phase inversion. The zeta potential and scanning electron microscopy results revealed a negative charge and a pleated surface microstructure with a high content of WPI-AF. FTIR analysis showed that the CMC and WPI-AF were cross-linked via glutaraldehyde and the interacting forces between membrane and MB or RF was found to be electrostatic interaction and hydrogen bonding, respectively. Next, the in vitro drug release from membranes was monitored using UV-vis spectrophotometry. Additionally, two empirical models were used to analyze the drug release data and relevant rate constant and parameters were determined accordingly. Moreover, our results indicated that in vitro drug release rates depended on the drug-matrix interactions and transport mechanism, which could be controlled by altering the WPI-AF content in membrane. This research provides an excellent example of utilizing two-dimensional amyloid-based materials for drug delivery.

Colonic Intramural Hematoma in a Cat: A Case Report.

Colonic intramural hematoma is a rare condition in humans and companion animals. Its clinical presentation in cats has not previously been reported. An 8-year-old male American shorthair cat presented with acute onset of constipation and anorexia for 3 days. Laboratory examination indicated mild elevation of alanine aminotransferase, globulin, and total protein levels. Complete blood count was normal. Radiographs revealed a soft tissue opacity mass located caudodorsally to the urinary bladder, causing narrowing of the descending colonic lumen. Sonography showed a heteroechogenic intraluminal mass containing liquefied content between the submucosal and muscular layers of the descending colon. On computed tomographic images, the mass contained two different attenuated contents with an interface. Colonoscopy was then performed for intestinal biopsy, and the contents observed in the intraluminal mass were drained via surgical evacuation and considered as blood clots. Supportive medical treatment, including antibiotics and fecal softener, was administered, and the clinical signs resolved uneventfully. Mild chronic proctitis without apparent malignancy was confirmed histopathologically, and no recurrence was observed after more than 14 months, and thus a colonic intramural hematoma was presumptively diagnosed. The information provided by multimodal imaging of the mass was essential for the diagnosis and determination of the treatment in this case.

Effects of stress on eating behaviours in adolescents: a daily diary investigation.

OBJECTIVE: The current study aimed to use ecologically valid assessments to examine within- and between-person associations between adolescents' daily stress and unhealthy eating behaviours. Design: Daily diary assessments were used to investigate whether daily perceived stress and negative life events were associated with naturally occurring eating behaviours across the span of one week in a community-based sample of 88 adolescents. Results: Logistic hierarchical models demonstrated between-person effects of stress on eating, such that adolescents who endorsed greater perceived stress and more daily negative life events, on average, across the one-week period, also reported elevated rates of craving tasty foods and trouble stopping the consumption of tasty foods. Within-person findings showed that some eating behaviours were associated with day-to-day, within-person fluctuations in stressful experiences. On days marked by higher than usual perceived stress (relative to one's own average levels during the week), adolescents reported an increased likelihood of eating to cope with difficult emotions. Conclusions: Findings indicate that daily fluctuations in stress may contribute to unhealthy eating behaviours during adolescence, and that associations between stress and eating behaviour may differ depending on whether they are assessed within-person or between-persons.

Implementation and outcomes of an antimicrobial stewardship program: Effectiveness of education.

BACKGROUND: Unnecessary use of antibiotics is a common occurrence in hospitals. Implementation of antibiotic stewardship programs (ASPs) has been shown to reduce both unnecessary antibiotic use and drug-resistant bacteria. Education is a fundamental component of an ASP. However, the effectiveness of proper uses of antibiotics education has not been clearly analyzed. METHODS: In a 520-bed university hospital located in northeastern Taiwan, a significantly increasing prescription of carbapenems, specifically imipenem and meropenem, was observed. An educational program highlighting the judicious use of carbapenems was started, beginning in October 2013. A multidisciplinary ASP was implemented starting in January 2014. The consumption of antibiotics, measured by defined daily dose per 1000 occupied bed-days, was compared among the pre-educational, posteducational, and post-ASP periods. RESULTS: Compared with the pre-educational period, there was a significant reduction in antibiotics consumption of 13% total inpatient antibiotics (p = 0.008), 29.8% carbapenems (p = 0.001), 34.9% imipenem and meropenem (p < 0.001), and 27% glycopeptides (p = 0.015), in the posteducational and post-ASP periods. The major reduction emerged during the posteducational period and was sustained after the ASP. The percentage of inpatients prescribed with antibiotics was significantly decreased (16.2%; p < 0.001). The rate of carbapenem-resistant Acinetobacter baumannii decreased from 70.8% to 29.6% within 7 months. CONCLUSION: A focused educational program is effective in controlling the prescription of specific antibiotic classes in the early phase of a multidisciplinary ASP.

Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.

Steroidogenesis-mediated production of neurosteroids is important for brain homeostasis. Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistance. However, whether CYP17A1-mediated DHEA synthesis is involved in brain tumor malignancy, especially in glioma, the most prevalent brain tumor, is unknown. To investigate the role of CYP17A1 in glioma, we determined that CYP17A1 expression is significantly increased in gliomas, which secrete more DHEA than normal astrocytes. We found that as gliomas became more malignant, both CYP17A1 and DHEA were significantly upregulated in temozolomide (TMZ)-resistant cells and highly invasive cells. In particular, the increase of CYP17A1 was caused by Sp1-mediated DNA demethylation, whereby Sp1 competed with DNMT3a for binding to the CYP17A1 promoter in TMZ-resistant glioma cells. CYP17A1 was required for the development of glioma cell invasiveness and resistance to TMZ-induced cytotoxicity. In addition, DHEA markedly attenuated TMZ-induced DNA damage and apoptosis. Together, our results suggest that components of the Sp1-CYP17A1-DHEA axis, which promotes the development of TMZ resistance, may serve as potential biomarkers and therapeutic targets in recurrent glioma.

Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.

Ubiquitin is a critical modifier regulating the degradation and function of its target proteins during posttranslational modification. Here we found that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples. Studying single-nucleotide polymorphisms (SNPs) of USP24 using genomic DNA of lung cancer patients revealed an increase in SNP 7656C/T. When using RNA specimens instead of the genomic DNA of lung cancer patients, we found significant increases in the ratios of variants 930C/T and 7656T/C, suggesting that variants at these two sites are not only caused by the SNP of DNA but also by the RNA editing. USP24-930T and USP24-7656C increase USP24 expression levels by increasing RNA stability. Knocking down USP24 increased Suv39h1 level through a decrease in mouse double-minute 2 homolog levels, thus enhancing lysine-9 methylation of histone H3, and resulting in the prevention of lung cancer malignancy. In conclusion, as USP24 variant analysis revealed a higher ratio of variants in blood specimens of lung cancer patients than that in normal individuals, USP24-930T and USP24-7656C might be useful as diagnostic markers for cancer detection.