Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 39
Filtrar
Más filtros

Bases de datos
País/Región como asunto
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
J Environ Manage ; 320: 115785, 2022 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-36056478

RESUMEN

The rapid economic development has highlighted the global climate change problem and carbon dioxide emissions have brought challenges to global climate change. The combined carbon emissions of the United States and China are nearly half of global carbon emissions. These two countries have made great contributions to environmental protection and responded actively to global warming, and set the goal of carbon neutrality. This study takes the United States and China as examples to compare their national paths and policies to achieve carbon neutrality while also analyzing the stage effects of carbon emission reduction in these two countries. This study found that the policy systems in the United States and China are opposites of each other. The United States is a "Bottom to Top" system while China is a "Top to Bottom". The CO2 emission in the United States is currently in the absolute carbon emission reduction period, that is, the reduction of total carbon emissions; while China is in the relative carbon emission reduction period, that is, the reduction of carbon emission intensity. China's transition time from carbon peaking to carbon neutrality is shorter than that of the United States, which is a huge challenge for China because its population is much larger than that of the United States. The results of this research can be used by other countries and regions for supporting carbon reduction policy decision-making and achieving UN sustainable development goals (SDGs).


Asunto(s)
Dióxido de Carbono , Desarrollo Económico , Dióxido de Carbono/análisis , China , Cambio Climático , Políticas , Estados Unidos
2.
J Minim Access Surg ; 18(4): 578-584, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35899917

RESUMEN

Background: To summarise data from previous reports and perform a meta-analysis to compare the short-term surgical outcomes and post-operative recovery between single-incision and multi-port laparoscopic distal gastrectomy (MLDG) for gastric cancer. Methods: A systematic literature search was performed using PubMed and Embase databases and relevant data were extracted. Short-term surgical outcomes and post-operative recovery of single-incision laparoscopic distal gastrectomy (SLDG) and MLDG for gastric cancer were compared using a fixed or random-effect model. Results: In total, we identified five relevant studies involving 983 participants for this systematic review and meta-analysis, and 45.8% (450/983) of patients underwent SLDG. The results demonstrated that mean operation time (weighted mean difference [WMD]:-3.22, 95% confidence interval [CI]: 14.64,8.19, P = 0.580; I2 = 75.6%), intra-operative blood loss (WMD:-19.77, 95% CI: 40.20,0.65, P = 0.058; I2 = 85.0%) and lymph node yield (WMD:-0.71, 95% CI: 1.47, 0.05, P = 0.068; I2 = 0%) of SLDG were comparable to those of MLDG for gastric cancer. In addition, SLDG had a similar incidence of post-operative complications compared with MLDG (odds ratio: 0.82, 95% CI: 0.55-1.22, P = 0.326; I2 = 0%). There was no significant difference between the two surgical procedures for the conversion to open surgery (OR: 0.32, 95%CI: 0.03-3.15, P = 0.331; I2 = 0%), the length of hospital stay (WMD:-0.05, 95% CI: 0.65, 0.55, P = 0.876; I2 = 44.1%), the time to first flatus (WMD:-0.24, 95% CI: 0.58, 0.10, P = 0.169; I2 = 85.3%) and the time to oral intake (WMD:-0.05, 95% CI: 0.20, 0.10, P = 0.500; I2 = 0%). Conclusion: Single-incision laparoscopic gastrectomy may be technically feasible and safe for gastric cancer. However, it did not show a more obvious advantage over MLDG.

3.
J Clean Prod ; 188: 38-48, 2018 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-32288345

RESUMEN

Cities have been one of the most important areas of CO2 emissions. It is increasingly important to research the effect of urbanization on CO2 emissions, especially in large emerging and developing economies, due to the indispensable need for understanding the effect of urbanization on CO2 emissions, evaluating carbon reduction tasks and providing the scientific basis for low-carbon urbanization. Utilizing a balanced panel dataset in the Yangtze River Delta (YRD), China, during the period of 2000-2010, this paper employed data envelopment analysis (DEA) window analysis and a spatial lag panel Tobit model to investigate the effect of urbanization on CO2 emissions efficiency (the ratio of the target CO2 emissions to the actual CO2 emissions). The results show that the average CO2 emissions efficiency was 0.959 in 2010, and CO2 emissions efficiency ranged from 0.816 to 1 and exhibited spatial clustering in the region. The larger potential of CO2 emissions reduction appeared in Zhenjiang and Yangzhou, indicating that more CO2 emissions reduction tasks should be allocated to these two cities. Urbanization has negative effects on improving CO2 emissions efficiency, and there is a U-curve relation between CO2 emissions efficiency and urbanization, indicating that CO2 emissions efficiency decreases at the early stage of urbanization, then increases when urbanization reach a high level. There is spatial spillover effect among the prefecture-level cities, suggesting that different prefecture-level governments should coordinate with each other to improve CO2 emissions efficiency in the whole area. Gross domestic product (GDP) per capita also plays a markedly positive role in improving CO2 emissions efficiency. This research highlights the effect of urbanization on CO2 emissions efficiency and the importance of improving CO2 emissions efficiency in developing countries.

4.
Nature ; 537(7619): 167, 2016 09 08.
Artículo en Inglés | MEDLINE | ID: mdl-27604941
5.
Habitat Int ; 60: 58-68, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-32287708

RESUMEN

As China's industrialization and urbanization have grown rapidly in recent years, China's CO2 emissions rose from 3405.1799 Mt to 10,249.4630 Mt from 2000 to 2013, and it has reached the highest levels in the word since 2006. Chinese government has emphasized the importance of reducing carbon emissions and set the target of reducing carbon intensity to 60-65% of 2005 levels by 2030. Investigating the convergence of carbon intensity can identify the convergence rate, which is helpful in guiding allocations of carbon intensity reduction. The Yangtze River Delta is one of the key carbon emission regions in China, with higher urbanization levels and larger carbon emissions; thus, we employed prefecture-level panel data derived from grid data between 2000 and 2010 to examine whether the convergence of carbon intensity exists across prefecture-level cities in the Yangtze River Delta. Spatial panel data models were utilized to investigate ß-convergence of carbon intensity. The results indicated that carbon intensity showed divergence during 2002-2004 and σ-convergence over other periods (2000-2002 and 2004-2010). Carbon intensity exhibited stochastic convergence, indicating that the shocks to carbon intensity relative to the average level of carbon intensity are only transitory. There was a spatial spillover effect and ß-convergence of carbon intensity, suggesting that prefecture-level cities with higher carbon intensity would decrease rapidly in the Yangtze River Delta. Our results highlight the importance of considering the present state of carbon intensity, spatial factors, and socioeconomic factors such as industrial structure and economic levels during allocation planning for reducing carbon intensity.

7.
Environ Sci Technol ; 49(21): 13021-30, 2015 Nov 03.
Artículo en Inglés | MEDLINE | ID: mdl-26421527

RESUMEN

China is undergoing rapid urbanization, enlarging the construction industry, greatly expanding built-up land, and generating substantial carbon emissions. We calculated both the direct and indirect carbon emissions from energy consumption (anthropogenic emissions) in the construction sector and analyzed built-up land expansion and carbon storage losses from the terrestrial ecosystem. According to our study, the total anthropogenic carbon emissions from the construction sector increased from 3,905×10(4) to 103,721.17×10(4) t from 1995 to 2010, representing 27.87%-34.31% of the total carbon emissions from energy consumption in China. Indirect carbon emissions from other industrial sectors induced by the construction sector represented approximately 97% of the total anthropogenic carbon emissions of the sector. These emissions were mainly concentrated in seven upstream industry sectors. Based on our assumptions, built-up land expansion caused 3704.84×10(4) t of carbon storage loss from vegetation between 1995 and 2010. Cropland was the main built-up land expansion type across all regions. The study shows great regional differences. Coastal regions showed dramatic built-up land expansion, greater carbon storage losses from vegetation, and greater anthropogenic carbon emissions. These regional differences were the most obvious in East China followed by Midsouth China. These regions are under pressure for strong carbon emissions reduction.


Asunto(s)
Contaminantes Atmosféricos/análisis , Carbono/análisis , Industria de la Construcción , Análisis Espacio-Temporal , China , Ecosistema , Actividades Humanas , Humanos , Plantas
8.
Nature ; 509(7502): 563, 2014 May 29.
Artículo en Inglés | MEDLINE | ID: mdl-24870531
9.
Environ Sci Pollut Res Int ; 31(19): 28564-28577, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38561534

RESUMEN

Analyzing the inequality characteristics and influencing factors of CO2 emissions per capita (CEPC) is conducive to balancing regional development and CO2 emissions reduction. This study applied the Gini coefficient and Theil index to investigate the CEPC inequalities during 2005-2017 at the county level in Jiangsu Province, China. Considering the spatial spillover and interaction effects, the factors influencing CEPC were analyzed by a hierarchical spatial autoregressive model. The results showed that the inequalities in CEPC first increased and then decreased at the inter-regional, and inter-county levels. The spatial pattern of CEPC was stable, and there was a significantly positive spatial autocorrelation of CEPC at the county level. The High-High type counties were mainly located in Sunan (southern Jiangsu). The spatial interaction effects of the CEPC between the prefecture and county levels indicated that governments at the prefecture level should integrate their county governments to reduce the CEPC. Moreover, carbon intensity, GDP per capita, land urbanization, and industrial structure play an important role in reducing CEPC. Our findings provide a scientific basis for formulating reasonable and effective carbon emission reduction policies.


Asunto(s)
Dióxido de Carbono , China , Dióxido de Carbono/análisis , Urbanización , Contaminación del Aire , Factores Socioeconómicos
10.
Micromachines (Basel) ; 15(6)2024 May 31.
Artículo en Inglés | MEDLINE | ID: mdl-38930708

RESUMEN

Under certain circumstances, a high-speed railway may require constant acceleration or emergency braking, in which case the inverter may experience short-term overload conditions and the current passing through the IGBT will go beyond the rated design tolerance. Under overload conditions, the IGBT loss will increase instantly, raising the power semiconductor device's junction temperature in the process. This research examines the boosting-gate-voltage-driven IGBT control technology. It increases the gate drive voltage and the IGBT current capacity and decreases the conduction voltage drop of IGBT under short-term overload conditions, reducing the instantaneous loss and temperature rise undulation of IGBT. The working characteristics of IGBT devices are studied, and the influence of gate drive voltage on device loss and temperature rise fluctuations is analyzed. Based on the emergency acceleration and brake conditions of the actual train operation, the short-term overload characteristics of the inverter are analyzed. The optimization analysis of the boosting gate voltage under emergency conditions is carried out, and the IGBT drive circuit with gate voltage pumping function is designed. The effectiveness of the driving circuit is verified through PSpice simulation and actual switching characteristic test. According to the analysis of experimental data, it can be verified that increasing the gate voltage technology can reduce IGBT losses.

11.
Environ Sci Pollut Res Int ; 30(19): 54586-54599, 2023 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-36877393

RESUMEN

In response to China's aims of becoming "carbon-neutral," the development of green industries such as renewable energy and recycling has flourished. Based on 2015 and 2019 data, this study uses spatial autocorrelation to analyze the evolution of land use by the green industries in Jiangsu Province. The Geodetector model was also applied to identify the driving factors underlying these spatial patterns. The spatial variability of green industrial land use in Jiangsu Province is significant, with the land-use area gradually decreasing from Southern to Northern Jiangsu. In terms of spatial-temporal changes, there is an increase in land use and a trend of expansion in the central and northern regions of Jiangsu. Land use by green industries in the province exhibits a more significant spatial clustering pattern but with a weakened clustering effect. The clustering types are mainly H-H and L-L, with the H-H type distributed mainly in the Su-Xi-Chang region and the L-L type distributed mainly in the Northern Jiangsu region. The levels of technology, economic development, industrialization, and industrial diversification are important individual driving factors, and the interaction among the different factors enhances their driving forces. This study suggests that spatial spillover effects should be focused to promote the coordinated development of regional energy-saving and environmental protection industries. At the same time, joint efforts should be made from the aspects of resources, government, economy, and related industries to promote the agglomeration of land for energy-saving and environmental protection industries.


Asunto(s)
Conservación de los Recursos Naturales , Urbanización , Industrias , Desarrollo Industrial , Desarrollo Económico , China
12.
Artículo en Inglés | MEDLINE | ID: mdl-35805308

RESUMEN

Exploring the impacts of perceived neighborhood environment on commuting behavior and travel-related CO2 emissions helps policymakers formulate regional low-carbon transport policies. Most studies have examined the impact of the objective measures of built environment on travel behavior and related CO2 emissions, and few studies have focused on perceived neighborhood environment. This study develops a structural equation model and uses data from a self-administered survey of urban full-time employees in Nanjing, China to examine the direct and indirect effects of perceived neighborhood environment on commuting mode choice and commuting CO2 emissions. The study shows that perceived service facilities has a significant direct effect on commuting mode and a significant indirect effect on commuting CO2 through the mediating effect of commuting mode choice. While socio-demographic variables such as gender have a significant direct impact on commuting mode and commuting CO2 emissions, they have an indirect impact on commuting mode and commuting CO2 emissions through the intermediate variables (such as car ownership, perceived neighborhood environment and commuting distance). The conclusions of this study show that the potential of commuting CO2 emissions reduction in China is enormous, and that policy interventions on commuting would help developing countries such as China achieve the goals of low-carbon transport and sustainable development.


Asunto(s)
Dióxido de Carbono , Viaje , Carbono , Dióxido de Carbono/análisis , China , Humanos , Transportes , Enfermedad Relacionada con los Viajes
13.
Front Environ Sci Eng ; 16(8): 111, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35855315

RESUMEN

China has been committed to achieving carbon neutrality by 2060. China's pledge of carbon neutrality will play an essential role in galvanising global climate action, which has been largely deferred by the Covid-19 pandemic. China's carbon neutrality could reduce global warming by approximately 0.2-0.3 °C and save around 1.8 million people from premature death due to air pollution. Along with domestic benefits, China's pledge of carbon neutrality is a "game-changer" for global climate action and can inspire other large carbon emitters to contribute actively to mitigate carbon emissions, particularly countries along the Belt and Road Initiative (BRI) routes. In order to achieve carbon neutrality by 2060, it is necessary to decarbonise all sectors in China, including energy, industry, transportation, construction, and agriculture. However, this transition will be very challenging, because major technological breakthroughs and large-scale investments are required. Strong policies and implementation plans are essential, including sustainable demand, decarbonizing electricity, electrification, fuel switching, and negative emissions. In particular, if China can peak carbon emissions earlier, it can lower the costs of the carbon neutral transition and make it easier to do so over a longer time horizon. China's pledge of carbon neutrality by 2060 and recent pledges at the 26th UN Climate Change Conference of the Parties (COP26) are significant contributions and critical steps for global climate action. However, countries worldwide need to achieve carbon neutrality to keep the global temperature from growing beyond the level that will cause catastrophic damages globally.

14.
ACS Omega ; 7(25): 21397-21406, 2022 Jun 28.
Artículo en Inglés | MEDLINE | ID: mdl-35785316

RESUMEN

Sequential extract residues (R i , i = 1, 2, 3, 4, and 5) were obtained from Hefeng acid-washing coal (HFAC) by petroleum ether, carbon disulfide, methanol, acetone, and isometric carbon disulfide/acetone mixture, sequentially. Pyrolysis behavior of the residues was determined using thermogravimetry analysis. The Coats-Redfern method with different reaction orders was used to analyze the pyrolysis kinetic of each sample, and the kinetic parameters, including correlation coefficient (R 2), activation energy (E), and pre-exponential factor (A), were calculated. Results showed that the weight loss of extract residues was higher than HFAC, and pyrolysis behavior varies greatly for residues, which is related to the unstable structure after extraction. From conversion-temperature (α-T) curves, the pyrolysis process was divided into three stages: low-temperature stage (150-350 °C), medium-temperature stage (350-550 °C), and high-temperature stage (550-950 °C). The medium-temperature stage made great contribution to the process of pyrolysis, which was dominated by depolymerization and decomposition reaction. The relationship between kinetic parameters and reaction order showed that the swelling effect is an important reason for the discrepancy of E for each sample in the process of pyrolysis.

15.
Artículo en Inglés | MEDLINE | ID: mdl-34639345

RESUMEN

High-speed rail (HSR) increases the non-local connections in cities and plays an essential role in urban land use efficiency. This paper uses a multi-period difference-in-difference model and a threshold model based on sample data that cover 284 Chinese cities from 2003-2018 to investigate the impact of HSR on urban land use efficiency. The results show that there is a 0.021 increase in urban land use efficiency after opening the HSR. The number of HSR stations and routes can increase the urban land use efficiency by 0.004 and 0.013, respectively. Compared with the cities in the East, the midwestern ones are more vulnerable to the impact of HSR. In particular, the positive impact of the number of HSR stations on the urban land use efficiency in cities with an urban population density exceeding 795 person/km2 is two times larger than cities with an urban population density of less than 795 person/km2. In addition, the impact of the number of HSR routes on urban land use efficiency in cities with an urban population density of less than 1003 person/km2 is five times larger than that of cities with an urban population density exceeding 1003 person/km2.


Asunto(s)
Eficiencia , China , Ciudades , Humanos , Población Urbana
16.
Artículo en Inglés | MEDLINE | ID: mdl-34831677

RESUMEN

Economic development and land-use change can strongly affect terrestrial ecosystems' carbon balance. This paper quantifies the changes in land use of Yangtze River Delta urban agglomeration (YRD) in 2020 and 2035 under three economic growth scenarios, exploring the concurrent impact on carbon storage. The results showed that the land carbon storage of YRD had decreased by 1453.80 Tg in 2000-2020, and will continue to decrease by 982.38 Tg, 1417.62 Tg, and 1636.21 Tg under the scenarios of a slow, medium, and rapid economic growth from 2020 to 2035, respectively. The large-scale occupation of cultivated land and woodland for construction land caused by economic development and population growth was an important reason. The occupation of cultivated land by construction land in Nanjing, Shanghai, and its surrounding areas had further intensified, while the reduction in carbon storage caused by the reduction in woodland had become more prominent in Hangzhou, Shaoxing, Jinhua, and the surrounding areas.


Asunto(s)
Desarrollo Económico , Ríos , Carbono/análisis , China , Ciudades , Ecosistema , Urbanización
17.
ACS Omega ; 6(25): 16373-16380, 2021 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-34235308

RESUMEN

Three Ni-Al2O3 catalysts were prepared, in planetary ball-milling machine, by the mechanochemical method with Al(NO3)3·9H2O as the aluminum precursor, (NH4)2CO3 as the precipitant, and Ni(NO3)2·6H2O, NiCl2·6H2O, and Ni(CH3COO)2·4H2O as nickel precursors (the corresponding catalysts were labeled as Ni-NO, Ni-Cl, and Ni-Ac). The prepared catalysts were characterized by X-ray diffraction (XRD), temperature-programmed reduction (H2-TPR), and N2 adsorption-desorption technologies, and CO methanation performance evaluation was carried out for the catalysts. Results showed that the catalyst with Ni(NO3)2·6H2O as the precursor presented good Ni dispersibility and a small Ni grain size of 6.80 nm. CO conversion, CH4 selectivity, and yield of the catalyst were as high as 78.8, 87.9, and 69.8%, respectively. Carbon deposition analysis from temperature-programmed hydrogenation (TPH) characterization showed that the H2 consumption peak area of the three samples followed the order: Ni-NO (2886.66 au) < Ni-Cl (4389.97 au) < Ni-Ac (5721.65 au), indicating that the Ni-NO catalyst showed higher resistance to carbon deposition, which might be due to its small Ni grain size.

18.
ACS Omega ; 6(25): 16381-16390, 2021 Jun 29.
Artículo en Inglés | MEDLINE | ID: mdl-34235309

RESUMEN

Modified Ni-Al2O3 catalysts with Ca, Co, and Ce species as promoters were prepared by the combustion method, and the structure, morphology, reduction characteristic, and CO2-CH4 reforming of the catalysts were discussed by X-ray diffraction (XRD), H2-temperature-programmed reduction (H2-TPR), energy-dispersive X-ray (EDX) mapping, NH3-temperature-programmed desorption (NH3-TPD), N2 adsorption-desorption, thermogravimetric-differential thermal analysis (TG-DTG), and temperature-programmed hydrogenation (TPH) methods. The crystal size of Ni on Ca-Ni-Al2O3 was 16.97 nm, and the active component and additive were distributed well in the catalyst. Co-Ni-Al2O3 presented a surface area of 65.70 m2·g-1 and a pore diameter of 161.60 nm. Ce-Ni-Al2O3 showed relatively stable nickel-aluminum spinel (NiAl2O4), which could not be easily reduced to the active component Ni. Evaluation results demonstrated that the performance of the catalysts followed the order Co-Ni-Al2O3 > Ca-Ni-Al2O3 > Ni-Al2O3 > Ce-Ni-Al2O3. Carbon deposition analysis showed that the carbon resistance of Ca-Ni-Al2O3 was poor and graphitic carbon was generated on the catalyst. However, Ce-Ni-Al2O3 showed less carbon deposition, which might have resulted from the lower activity of the catalyst.

19.
Artículo en Inglés | MEDLINE | ID: mdl-34574597

RESUMEN

Citizen environmental complaints play a key role in China's current environmental monitoring network and environmental governance system. Based on 5796 cases of environmental complaints lodged by citizens via hotline and the internet to the MEP of China, we examined the spatial characteristics and influencing factors of citizen complaints for the period of 2013-2017 using spatial analysis methods and spatial econometric models. The roles of citizen complaints in the two systems were then reevaluated. The results show that, among all cases, 75.88% of cases were identified as verified complaints, while nearly a 25% noisy rate directed large amounts of inspection resources to be utilized in response to nonverified cases. Air pollution received the most attention by citizens in China, accounting for 67.22% of total cases. The hotspots of citizen complaints were mostly distributed in the three major national urban agglomerations in China. We found that industrial wastewater and SO2 were positively associated with the likelihood of citizens filing complaints, while the effect of industrial soot/dust emission was insignificant. Citizen complaints might be triggered by certain, but not all, forms of pollutants, even though highly visible particulate pollutants did not necessarily induce corresponding complaints. Moreover, the negative relationship between citizen complaints and per capita GDP revealed the unbalanced geographical pattern between economical development and environmental quality. The proliferation of the internet greatly facilitated citizens lodging complaints through various ways. The synergy mechanism between citizen environmental complaints and other parts in China's environmental monitoring and governance system should be established in the future.


Asunto(s)
Contaminantes Atmosféricos , Contaminación del Aire , Contaminantes Atmosféricos/análisis , Contaminación del Aire/análisis , China , Ciudades , Conservación de los Recursos Naturales , Monitoreo del Ambiente , Política Ambiental , Material Particulado/análisis , Análisis Espacial
20.
Exp Ther Med ; 22(6): 1465, 2021 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-34737805

RESUMEN

Cisplatin (DDP) resistance is one of the main causes of treatment failure in patients with colon cancer (CC). Autophagy is a key mechanism of resistance to chemotherapy. Since autophagy-related 7 (ATG7) has been reported to be involved in the regulation of autophagy and DDP resistance for lung and esophageal cancer, the present study aimed to explore the functions of microRNA (miR)-4486 in the autophagy-mediated DDP resistance of CC. The expression level of miR-4486 in HCT116, DDP-resistant HCT116 cells (HCT116/DDP), SW480 and DDP-resistant SW480 cells (SW480/DDP) was quantified by reverse transcription-quantitative PCR. Western blotting was utilized to analyze the expression of ATG7, autophagy-related proteins Beclin 1 and LC3-I/II, as well as apoptosis-related proteins Bcl-2, Bax and cleaved-caspase 3 in HCT116/DDP and SW480/DDP cells. The half maximal inhibitory concentration of DDP on all cell lines and the cell viability of HCT116/DDP and SW480/DDP cells were measured using Cell Counting Kit 8 assay. Luciferase assay was used to examine the potential targets of miR-4486 and ATG7. The effects of upregulating mimic miR-4486 expression on the apoptosis and autophagy of HCT116/DDP and SW480/DDP cells were determined by flow cytometry and electron microscopy, respectively. It was found that miR-4486 expression was significantly decreased in HCT116/DDP and SW480/DDP cells compared with that in HCT116 and SW480 cells. Overexpression of miR-4486 could increase the sensitivity of HCT116/DDP and SW480/DDP cells to DDP by reducing cell viability, promoting apoptosis and inhibiting autophagy through downregulating Beclin 1 expression and the LC3-II/LC3-I ratio. Additionally, ATG7 was identified to be a target gene of miR-4486, where ATG7 overexpression could partially reverse the effects of miR-4486 on cell viability and apoptosis by promoting the formation of autophagosomes. In conclusion, the present results demonstrated that miR-4486 could reverse DDP resistance in HCT116/DDP and SW480/DDP cells by targeting ATG7 to inhibit autophagy.

SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA