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1.

Large-scale multiplexed mosaic CRISPR perturbation in the whole organism.

Liu, Bo; Jing, Zhengyu; Zhang, Xiaoming; Chen, Yuxin; Mao, Shaoshuai; Kaundal, Ravinder; Zou, Yan; Wei, Ge; Zang, Ying; Wang, Xinxin; Lin, Wenyang; Di, Minghui; Sun, Yiwen; Chen, Qin; Li, Yongqin; Xia, Jing; Sun, Jianlong; Lin, Chao-Po; Huang, Xingxu; Chi, Tian.

Cell; 185(16): 3008-3024.e16, 2022 08 04.

Artículo en Inglés | MEDLINE | ID: mdl-35870449

2.

3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis.

Ke, Yuwen; Xu, Yanan; Chen, Xuepeng; Feng, Songjie; Liu, Zhenbo; Sun, Yaoyu; Yao, Xuelong; Li, Fangzhen; Zhu, Wei; Gao, Lei; Chen, Haojie; Du, Zhenhai; Xie, Wei; Xu, Xiaocui; Huang, Xingxu; Liu, Jiang.

Cell; 170(2): 367-381.e20, 2017 Jul 13.

Artículo en Inglés | MEDLINE | ID: mdl-28709003

3.

A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility.

Guo, Junfan; Yu, Wenxia; Li, Min; Chen, Hongyu; Liu, Jie; Xue, Xiaowen; Lin, Jianxiang; Huang, Shisheng; Shu, Wenjie; Huang, Xingxu; Liu, Zhen; Wang, Shengqi; Qiao, Yunbo.

Mol Cell; 83(10): 1710-1724.e7, 2023 05 18.

Artículo en Inglés | MEDLINE | ID: mdl-37141888

4.

Programming and inheritance of parental DNA methylomes in mammals.

Wang, Lu; Zhang, Jun; Duan, Jialei; Gao, Xinxing; Zhu, Wei; Lu, Xingyu; Yang, Lu; Zhang, Jing; Li, Guoqiang; Ci, Weimin; Li, Wei; Zhou, Qi; Aluru, Neel; Tang, Fuchou; He, Chuan; Huang, Xingxu; Liu, Jiang.

Cell; 157(4): 979-991, 2014 May 08.

Artículo en Inglés | MEDLINE | ID: mdl-24813617

5.

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.

Niu, Yuyu; Shen, Bin; Cui, Yiqiang; Chen, Yongchang; Wang, Jianying; Wang, Lei; Kang, Yu; Zhao, Xiaoyang; Si, Wei; Li, Wei; Xiang, Andy Peng; Zhou, Jiankui; Guo, Xuejiang; Bi, Ye; Si, Chenyang; Hu, Bian; Dong, Guoying; Wang, Hong; Zhou, Zuomin; Li, Tianqing; Tan, Tao; Pu, Xiuqiong; Wang, Fang; Ji, Shaohui; Zhou, Qi; Huang, Xingxu; Ji, Weizhi; Sha, Jiahao.

Cell; 156(4): 836-43, 2014 Feb 13.

Artículo en Inglés | MEDLINE | ID: mdl-24486104

6.

Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos.

Jiang, Lan; Zhang, Jing; Wang, Jing-Jing; Wang, Lu; Zhang, Li; Li, Guoqiang; Yang, Xiaodan; Ma, Xin; Sun, Xin; Cai, Jun; Zhang, Jun; Huang, Xingxu; Yu, Miao; Wang, Xuegeng; Liu, Feng; Wu, Chung-I; He, Chuan; Zhang, Bo; Ci, Weimin; Liu, Jiang.

Cell; 153(4): 773-84, 2013 May 09.

Artículo en Inglés | MEDLINE | ID: mdl-23663777

7.

Towards precise large genomic fragment deletion.

Li, Xiangyang; Huang, Xingxu.

Trends Genet; 38(3): 214-215, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34872747

8.

Restoring T and B cell generation in X-linked severe combined immunodeficiency mice through hematopoietic stem cells adenine base editing.

Zhang, Lu; Li, Kai; Liu, Zhiwei; An, Lisha; Wei, Haikun; Pang, Shanshan; Cao, Zongfu; Huang, Xingxu; Jin, Xiaohua; Ma, Xu.

Mol Ther; 2024 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-38532630

9.

PE-STOP: A versatile tool for installing nonsense substitutions amenable for precise reversion.

Song, Ziguo; Zhang, Guiquan; Huang, Shuhong; Liu, Yao; Li, Guanglei; Zhou, Xianhui; Sun, Jiayuan; Gao, Pengfei; Chen, Yulin; Huang, Xingxu; Liu, Jianghuai; Wang, Xiaolong.

J Biol Chem; 299(8): 104942, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37343700

10.

REPAIRx, a specific yet highly efficient programmable A > I RNA base editor.

Liu, Yajing; Mao, Shaoshuai; Huang, Shisheng; Li, Yongqin; Chen, Yuxin; Di, Minghui; Huang, Xinxin; Lv, Junjun; Wang, Xinxin; Ge, Jianyang; Shen, Shengxi; Zhang, Xiaoming; Liu, Dahai; Huang, Xingxu; Chi, Tian.

EMBO J; 39(22): e104748, 2020 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-33058207

11.

Programmable C-to-U RNA editing using the human APOBEC3A deaminase.

Huang, Xinxin; Lv, Junjun; Li, Yongqin; Mao, Shaoshuai; Li, Zhifang; Jing, Zhengyu; Sun, Yidi; Zhang, Xiaoming; Shen, Shengxi; Wang, Xinxin; Di, Minghui; Ge, Jianyang; Huang, Xingxu; Zuo, Erwei; Chi, Tian.

EMBO J; 39(22): e104741, 2020 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-33058229

12.

Point-of-care testing of methamphetamine and cocaine utilizing wearable sensors.

Wang, Ying; Li, Ke; Shen, Weijian; Huang, Xingxu; Wu, Lina.

Anal Biochem; 691: 115526, 2024 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-38621604

13.

m⁶A facilitates hippocampus-dependent learning and memory through YTHDF1.

Shi, Hailing; Zhang, Xuliang; Weng, Yi-Lan; Lu, Zongyang; Liu, Yajing; Lu, Zhike; Li, Jianan; Hao, Piliang; Zhang, Yu; Zhang, Feng; Wu, You; Delgado, Jary Y; Su, Yijing; Patel, Meera J; Cao, Xiaohua; Shen, Bin; Huang, Xingxu; Ming, Guo-Li; Zhuang, Xiaoxi; Song, Hongjun; He, Chuan; Zhou, Tao.

Nature; 563(7730): 249-253, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-30401835

14.

Quantitative analysis of a novel DNA hypermethylation panel using bronchial specimen for lung cancer diagnosis.

Dou, Maosen; Li, Dan; Zhu, Mengchan; Guo, Wei; Miao, Changhong; Li, Min; Xue, Ying; He, Ruiping; Jiang, Nan; Ge, Di; Hu, Qin; Shao, Yue; Hou, Yingyong; Wang, Xuefei; Huang, Xingxu; Liu, Tianshu; Wang, Qi; Wang, Yuehong; Sun, Jiayuan; Wang, Weibing; Song, Yuanlin; Hu, Jie; Huang, Qihong.

Int J Cancer; 153(5): 1096-1107, 2023 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-37232006

15.

A DNA methylation signature for the prediction of tumour recurrence in stage II colorectal cancer.

Li, Min; Zhu, Congcong; Xue, Ying; Miao, Changhong; He, Ruiping; Li, Wei; Zhang, Baolong; Yu, Wenqiang; Huang, Xingxu; Lv, Minzhi; Xu, Ye; Huang, Qihong.

Br J Cancer; 128(9): 1681-1689, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-36828869

16.

A Cas12a-based fluorescent microfluidic system for rapid on-site human papillomavirus diagnostics.

Huang, Baicheng; Lou, Yufeng; Zeng, Zihan; Kan, Xingchi; Shi, Xinping; Wu, Yue; Guo, Ling; Wang, Muzhen; Huang, Xingxu; Tian, Xuemei; Wang, Xinjie.

Appl Microbiol Biotechnol; 107(20): 6287-6297, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37626187

17.

Broadening prime editing toolkits using RNA-Pol-II-driven engineered pegRNA.

Huang, Shisheng; Zhang, Zhenwu; Tao, Wanyu; Liu, Yao; Li, Xiangyang; Wang, Xiaolong; Harati, Javad; Wang, Peng-Yuan; Huang, Xingxu; Lin, Chao-Po.

Mol Ther; 30(9): 2923-2932, 2022 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-35799444

18.

Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos.

Dang, Lu; Zhou, Xueliang; Zhong, Xiufang; Yu, Wenxia; Huang, Shisheng; Liu, Hanyan; Chen, Yuanyuan; Zhang, Wuwen; Yuan, Lihua; Li, Lei; Huang, Xingxu; Li, Guanglei; Liu, Jianqiao; Tong, Guoqing.

Mol Ther; 30(1): 175-183, 2022 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-33974999

19.

Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy.

Lu, Zongyang; He, Siting; Jiang, Jian; Zhuang, Ling; Wang, Yan; Yang, Guang; Jiang, Xiaoyu; Nie, Yanhong; Fu, Jiqiang; Zhang, Xiaotong; Lu, Yong; Bian, Xinyan; Chang, Hung-Chun; Xiong, Zhiqi; Huang, Xingxu; Liu, Zhen; Sun, Qiang.

Mol Ther; 30(6): 2163-2175, 2022 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-35283272

20.

Efficient DNA interrogation of SpCas9 governed by its electrostatic interaction with DNA beyond the PAM and protospacer.

Zhang, Qian; Chen, Ziting; Wang, Fangzhu; Zhang, Siqi; Chen, Hongyu; Gu, Xueying; Wen, Fengcai; Jin, Jiachuan; Zhang, Xia; Huang, Xingxu; Shen, Bin; Sun, Bo.

Nucleic Acids Res; 49(21): 12433-12444, 2021 12 02.

Artículo en Inglés | MEDLINE | ID: mdl-34850124

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