RESUMEN
The zoonotic disease trichinellosis is considered one of the re-emerging diseases with surveillance and control methods constantly gaining more importance worldwide. Recent change in European Union (EU) legislation introduces Trichinella-free production, and the possibility of risk-based monitoring for Trichinella in pigs. This has increased the role of wildlife surveillance programmes and their impact on protecting human health as well as highlighted the need for harmonised surveillance protocols and test methods for these infections. A modified digest method, based on the EU reference method for Trichinella testing of pig meat, was used to screen foxes present in Great Britain (England, Scotland and Wales) for trichinellosis. The method was validated using batched pools of 10 g foreleg muscle from up to 20 foxes (maximum amount 200 g). The method gave an average trichinae recovery rate of 71% for spiked samples. Assuming this recovery rate applies to all contaminated samples, then the test sensitivity would be 70% for all tissue samples with 0.1 trichinae per 10 g of foreleg muscle, 99.9% for samples with 1 trichinae per 10 g, and 100% for samples with 2 or more trichinae per 10 g. In two separate studies, conducted between 1999 to 2001 (Smith et al., 2003) and 2003 to 2007, over 3500 wild foxes have been screened for Trichinella with negative results. In the second study reported here, foxes were collected from locations throughout Great Britain using a stratified sampling method based on fox population densities. All work was conducted in compliance with appropriate quality assurance systems, latterly under ISO 9001. Results to date indicate the national prevalence of trichinellosis in foxes is <0.001 based on a 10 g individual sample size, an infection level of 1 larva per gram (l pg) and 95% confidence interval. This, together with no reports of trichinellosis in domesticated pigs, suggests that Britain can be considered a region of negligible risk of trichinellosis.
Asunto(s)
Pruebas Diagnósticas de Rutina/veterinaria , Zorros/parasitología , Helmintiasis Animal/diagnóstico , Trichinella/aislamiento & purificación , Triquinelosis/veterinaria , Animales , Pruebas Diagnósticas de Rutina/métodos , Helmintiasis Animal/epidemiología , Larva , Ratones , Músculo Esquelético/parasitología , Vigilancia de la Población , Prevalencia , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Triquinelosis/diagnóstico , Triquinelosis/epidemiología , Reino Unido/epidemiologíaRESUMEN
RATIONALE AND OBJECTIVES: The authors surveyed current residents and practicing radiologists to assess motivations for and attitudes about radiology moonlighting during residency. METHODS: One thousand one hundred current fourth-year radiology residents and 1,100 practicing radiologists who finished training within the past 10 years were surveyed. Information was solicited concerning motivations for and attitudes toward moonlighting and the effects of moonlighting on residents' training. Current residents were compared with former residents to assess changes in attitudes about moonlighting. RESULTS: There were no important differences in the practicing and training cohorts. Of each group, 52% moonlighted. Debt was the main motivating factor influencing a resident's decision to moonlight. Moonlighters owed significantly more money (average debt, $25,804) at the beginning of their residency than did non-moonlighters (average debt, $19,554). In addition, 72% of moonlighters had to begin loan repayments during training with average monthly payments of $284. Departmental policy was less of an influencing factor. There was no statistical difference in the way moonlighters and non-moonlighters spent their time with respect to clinical work, reading radiology, or participating in research. CONCLUSIONS: Residents moonlight primarily for financial reasons but also perceive a positive educational benefit. Although no significant negative effects on the residency were found in this study, rising debt, decreased forbearance of repayment, and possible resultant increases in the amount of time spent moonlighting, might eventually affect resident's productivity in more traditional residency activities.
Asunto(s)
Empleo , Internado y Residencia , Radiología/educación , Femenino , Humanos , Masculino , MotivaciónRESUMEN
Palpable breast consistency on physical examination was compared with the breast density on mammography for 909 consecutive patients. One of two experienced nurse practitioners palpated each patient's breasts and assigned a consistency value of 1 (little palpable breast consistency) to 4 (maximal palpable breast consistency). Seven mammographers rated the breast density on mammography as either fatty, mild, moderate, or marked parenchymal density for each breast. A low statistical correlation between the two parameters was shown. Thirty-seven percent of markedly dense breasts on mammography was rated only 1 or 2 on palpation. Thus, breast consistency judged by palpation cannot be directly correlated with the density shown on mammography and cannot be used to predict optimal radiographic technique.
Asunto(s)
Neoplasias de la Mama/prevención & control , Mamografía , Tamizaje Masivo/métodos , Palpación , Examen Físico/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Persona de Mediana EdadRESUMEN
RATIONALE AND OBJECTIVES: The authors previously showed that barium does not interfere with abdominal sonography performed after a biphasic upper gastrointestinal tract examination. This study was designed to assess the impact of a barium enema (BE) examination on the quality of abdominal sonography performed immediately after the barium enema. METHODS: Forty patients scheduled for routine barium enemas (22 air contrast and 18 solid column) were prospectively examined with abdominal sonography before and after their BEs. The resulting 80 sonograms were randomized; three radiologists blindly assessed the quality of images of each of six anatomic areas (aorta, pancreas, porta hepatis, gallbladder, and the right and left lobes of the liver). RESULTS: There was no statistically significant degradation of the images for the right and left lobes of the liver and the pancreas. However, the images for the gallbladder, porta hepatis, and aorta had a statistically significant (P < .05) degradation of their ultrasound quality following barium enema. CONCLUSIONS: Unlike upper gastrointestinal tract examination, BE examination does interfere with the quality of a subsequent abdominal ultrasonography. Thus, when both studies are required, sonography should be performed first.
Asunto(s)
Abdomen/diagnóstico por imagen , Sulfato de Bario , Adulto , Anciano , Aorta Abdominal/diagnóstico por imagen , Enema , Vesícula Biliar/diagnóstico por imagen , Humanos , Hígado/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Páncreas/diagnóstico por imagen , Estudios Prospectivos , Factores de Tiempo , Ultrasonografía/normasRESUMEN
OBJECTIVE: To examine the occurrence of breast fibroadenomas in postmenopausal patients referred for breast biopsy. DESIGN: A retrospective review of breast biopsy outcome and of patient demographics, including menstrual and hormonal status. SETTING: The Tucson Breast Center, a large outpatient breast cancer detection clinic affiliated with the University of Arizona Health Sciences Center in Tucson, Arizona. PARTICIPANTS: All women seen at the Tucson Breast Center between 1985 and 1990 who were referred for breast biopsy. RESULTS: A total of 100 fibroadenomas were found in 709 breast biopsies whose results were known. Fifty-two of these were in premenopausal women and 44 in postmenopausal women; the menopausal status of four women was unknown. In postmenopausal women, 11 of the 44 patients reported hormone use. Fibroadenomas constituted 20% (39 of 195) of the benign masses and 12% (39 of 339) of all breast masses in postmenopausal women. Fibroadenomas constituted 10% (44 of 447) of all biopsies in postmenopausal women, including those with breast masses, abnormal calcifications, or other lesions. CONCLUSION: Noncalcified fibroadenomas of the breast are not confined to young women and may constitute a small but noteworthy proportion of lesions coming to breast biopsy in postmenopausal women.
Asunto(s)
Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/patología , Fibroadenoma/epidemiología , Fibroadenoma/patología , Adulto , Anciano , Anciano de 80 o más Años , Arizona , Biopsia , Neoplasias de la Mama/diagnóstico por imagen , Calcinosis/diagnóstico por imagen , Calcinosis/patología , Femenino , Fibroadenoma/diagnóstico por imagen , Humanos , Incidencia , Mamografía , Persona de Mediana Edad , Posmenopausia , Estudios RetrospectivosRESUMEN
RATIONALE AND OBJECTIVES: The purpose of this study was to obtain long-term follow-up data on women with benign histologic results of a breast stereotactic core needle biopsy (CNB). MATERIALS AND METHODS: Mammography charts of 300 consecutive women who underwent prone stereotactic CNB with digital radiography were reviewed. Women with frankly malignant or suspicious histologic findings (51 patients) or a technically unsuccessful stereotactic CNB (one patient) were excluded. The remaining 248 benign core biopsies in 229 women were included in the study. RESULTS: Follow-up mammograms were obtained for 152 lesions with benign histologic results following stereotactic CNB. The mean length of follow-up after stereotactic CNB was 34.6 months. Cancer was diagnosed in six women who underwent surgical biopsies 1/2 to 30 months after benign stereotactic CNB. An initial chart review demonstrated that no follow-up data were available for 64 lesions, and information was missing for an additional seven. CONCLUSION: SCNB remains a sampling procedure that can result in false-negative histologic results. Intrinsic procedural issues were identified that could minimize the potential for missing a malignancy. Goals for patient compliance with follow-up recommendations fell short of expectations.
Asunto(s)
Biopsia con Aguja/métodos , Enfermedades de la Mama/patología , Adulto , Anciano , Anciano de 80 o más Años , Enfermedades de la Mama/diagnóstico por imagen , Neoplasias de la Mama/diagnóstico por imagen , Neoplasias de la Mama/patología , Calcinosis/diagnóstico por imagen , Calcinosis/patología , Carcinoma in Situ/diagnóstico por imagen , Carcinoma in Situ/patología , Carcinoma Ductal de Mama/diagnóstico por imagen , Carcinoma Ductal de Mama/patología , Diagnóstico Diferencial , Errores Diagnósticos , Progresión de la Enfermedad , Reacciones Falso Negativas , Femenino , Estudios de Seguimiento , Humanos , Hiperplasia/diagnóstico por imagen , Hiperplasia/patología , Mamografía , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Técnicas EstereotáxicasRESUMEN
RATIONALE AND OBJECTIVES: The purpose of this study was to survey academic radiology departments to determine how emergency radiology coverage is handled and whether there are any prerequisites for those individuals providing this coverage. MATERIALS AND METHODS: The authors developed a simple two-page survey and sent it to a total of 608 program directors, chiefs of diagnostic radiology, chairpersons, and chief residents at academic departments of radiology. RESULTS: Of the 608 surveys sent, 278 (46%) were returned. More than half of the departments have an emergency radiology section that provides "wet read" coverage during the day, and most academic departments cover the emergency department during the night and on weekends. Nighttime and weekend coverage is handled mostly by residents. Most departments give time off for lunch, with few other prerequisites for faculty who provide emergency coverage. Sixty percent of the departments have teleradiology capability, and many use it for emergency department coverage. CONCLUSION: These results can serve as the basis for discussion and comparison with other institutions regarding a variety of aspects of emergency department coverage.
Asunto(s)
Servicio de Urgencia en Hospital/organización & administración , Servicio de Radiología en Hospital/organización & administración , Recolección de Datos , Humanos , Admisión y Programación de Personal/organización & administraciónRESUMEN
The faecal egg count reduction test (FECRT) is widely used to assess the presence or absence of levamisole resistance in gastrointestinal nematodes in sheep flocks. However, in a recent study the FECRT appeared to falsely indicate the presence of levamisole resistance. One possible explanation for this result could have been that the anthelmintic failed to completely remove all immature stages of levamisole-susceptible strains, which then developed into egg laying adults and gave misleading results in the FECRT. Artificial infection of lambs with levamisole-susceptible, benzimidazole-resistant strains of Ostertagia circumcincta, Haemonchus contortus and Trichostrongylus colubriformis was followed by treatment with levamisole when the infections were between 2 and 10 days old. Levamisole was 84%, 88% and 98% effective against these immature stages of three species, respectively. The positive control, ivermectin, was more than 99% effective against all three species. The percentage faecal egg count reduction on samples taken 11 and 20 days post-treatment with levamisole was 80% and 78%, respectively. These results demonstrate that, due to the maturation of immature stages, the FECRT based on faecal eggs counts taken 11 or more days after treatment may give results indicative of levamisole resistance despite the absence of levamisole resistant strains of gastrointestinal nematodes.
Asunto(s)
Antinematodos/uso terapéutico , Sistema Digestivo/parasitología , Resistencia a Medicamentos , Heces/parasitología , Levamisol/uso terapéutico , Infecciones por Nematodos/veterinaria , Recuento de Huevos de Parásitos/veterinaria , Enfermedades de las Ovejas , Animales , Haemonchus , Larva , Infecciones por Nematodos/prevención & control , Ostertagia , Reproducibilidad de los Resultados , Ovinos , TrichostrongylusRESUMEN
The development of species and populations of parasitic helminths with resistance to one or more anthelmintics is an increasing problem world-wide. The majority of currently available anthelmintics used to control parasitic nematodes of cattle and sheep belong to only three main groups, the benzimidazoles, imidazothiazoles and the avermectins/milbemycins. The successful implementation of helminth control programmes designed to limit the development of resistance in nematode populations depends to some degree on the availability of effective and sensitive methods for its detection and monitoring. A variety of in vivo and in vitro tests have been developed for the detection of nematode populations resistant to the main anthelmintic groups, but each suffers to some degree from reliability, reproducibility, sensitivity and ease of interpretation. This review covers those tests that have been reported and described and highlights some of their strengths and weaknesses.
Asunto(s)
Antihelmínticos/farmacología , Helmintiasis Animal/tratamiento farmacológico , Helmintos/efectos de los fármacos , Pruebas de Sensibilidad Parasitaria/veterinaria , Animales , Animales Domésticos , Antihelmínticos/uso terapéutico , Bovinos , Enfermedades de los Bovinos/diagnóstico , Enfermedades de los Bovinos/tratamiento farmacológico , Enfermedades de los Bovinos/parasitología , Resistencia a Medicamentos , Helmintiasis Animal/diagnóstico , Helmintos/crecimiento & desarrollo , Recuento de Huevos de Parásitos/veterinaria , Pruebas de Sensibilidad Parasitaria/métodos , Sensibilidad y Especificidad , Ovinos , Enfermedades de las Ovejas/diagnóstico , Enfermedades de las Ovejas/tratamiento farmacológico , Enfermedades de las Ovejas/parasitología , Especificidad de la EspecieRESUMEN
Resistance to the benzimidazole (BDZ) class of anthelmintics in nematodes of sheep has become a common and global phenomenon. The rate at which the selection process and development of resistance occurs is influenced by a number of factors. Of these, the effects of stage-specific exposures to anthelmintic were investigated with a BDZ-resistant strain of Haemonchus contortus (HCR) over five parasite generations. Sheep were infected at each generation with the HCR strain and were treated with thiabendazole (TBZ), either 5 days post-infection (p.i.) (larval line), 21 days p.i. (adult line), or left untreated (no selection line). Additionally eggs from each generation were exposed to TBZ (egg line). Geometric worm burdens were calculated from post-mortem worm counts, both at the start of the study, and after the final selection studies for each of the selection lines. Egg hatch assays (EHAs) were also conducted throughout the study. All data relating to worm burdens and EHAs for each generation were analysed by linear regression to produce dose titration curves and lethal dose(50) (LD(50)) values for each of the selection lines. Over the five generations, LD(50) values on dose-response were increased and worm survival occurred at higher dose rates of TBZ irrespective of the parasite stage exposed to treatment. A similar picture was seen with ED(50) values, which showed a fluctuating but generally upward trend for each of the three selection lines. In contrast, LD(50) and ED(50) values were decreased in the no selection line, indicating some degree of reversion albeit to levels still considered to be BDZ-resistant.
Asunto(s)
Antihelmínticos/farmacología , Bencimidazoles/farmacología , Resistencia a Medicamentos , Haemonchus/efectos de los fármacos , Selección Genética , Enfermedades de las Ovejas/parasitología , Ovinos/parasitología , Envejecimiento , Animales , Antihelmínticos/uso terapéutico , Relación Dosis-Respuesta a Droga , Hemoncosis/tratamiento farmacológico , Hemoncosis/parasitología , Hemoncosis/veterinaria , Haemonchus/crecimiento & desarrollo , Dosificación Letal Mediana , Modelos Logísticos , Enfermedades de las Ovejas/tratamiento farmacológico , Factores de TiempoRESUMEN
The ivermectin sustained release bolus (IVSRB), when used at turnout as recommended, will provide season-long control of parasitic bronchitis, thus obviating the need for use of a lungworm vaccine. However, some concerns have been expressed that calves treated with an IVSRB will receive so little exposure to Dictyocaulus viviparus that it will compromise their immunity in subsequent grazing seasons, which would be of particular importance in dairy herds. Although there is evidence that IVSRB-treated calves can develop immunity to D. viviparus when exposed to pasture infection, it was considered worthwhile to evaluate the compatibility of the IVSRB and lungworm vaccination to allow veterinary surgeons the option of using these products concurrently when they have particular concerns about the long term immune status of replacement dairy heifers. Thirty-two dairy replacement heifers were vaccinated with two doses of lungworm vaccine and, at turnout, half the calves received an IVSRB and the remainder an oxfendazole pulse release bolus (OPRB). At the end of the grazing season four replicate bolus treated pairs and four parasite-naive calves were challenged with 1000 D. viviparus infective larvae. At slaughter there was a 95% and 93% reduction in D. viviparus burdens in the IVSRB and OPRB treated calves respectively, compared with the unvaccinated, untreated controls. These results indicate that where it is considered necessary to use lungworm vaccination in addition to an IVSRB or an OPRB, the compatibility of these products with lungworm vaccine will allow development of a protective level of immunity to D. viviparus.
Asunto(s)
Antihelmínticos/administración & dosificación , Bencimidazoles/administración & dosificación , Enfermedades de los Bovinos , Infecciones por Dictyocaulus/prevención & control , Dictyocaulus/aislamiento & purificación , Vacunación , Animales , Antihelmínticos/uso terapéutico , Bencimidazoles/uso terapéutico , Bovinos , Preparaciones de Acción Retardada , Dictyocaulus/inmunología , Infecciones por Dictyocaulus/inmunología , Femenino , Larva , Recuento de Huevos de ParásitosRESUMEN
Three worm control strategies, on a commercial farm in south east England, were monitored parasitologically for a grazing season. Three peaks of larval infection in June, late August and late October/early November occurred on paddocks grazed by dosed ewes and lambs on a new ley (preventive strategy). Lambs dosed and moved on to a hay aftermath in July (evasive strategy), had a mean egg count of 2090 by late August, attributable to infection with Haemonchus contortus. Three weekly drenching of lambs (suppressive strategy), suppressed faecal egg counts until September when the treatment interval was extended due to other on-farm commitments. In addition to these observations, autoinfection, with Haemonchus contortus, was seen to occur in lambs grazing summer turnips. An in vitro egg hatch assay, and critical efficacy trial, confirmed the presence of a benzimidazole resistant strain of Haemonchus contortus on this farm. The implications of these findings are discussed.
Asunto(s)
Gastroenteritis/veterinaria , Hemoncosis/veterinaria , Enfermedades de las Ovejas/parasitología , Tricostrongiloidiasis/veterinaria , Tricostrongiliasis/veterinaria , Animales , Animales Recién Nacidos , Inglaterra , Heces/parasitología , Femenino , Gastroenteritis/parasitología , Gastroenteritis/prevención & control , Hemoncosis/prevención & control , Recuento de Huevos de Parásitos/veterinaria , Ovinos , Enfermedades de las Ovejas/prevención & control , Tricostrongiliasis/prevención & controlRESUMEN
The term 'anthelmintic drug resistance' describes the heritable ability of some nematode parasites to survive treatment with anthelmintic drugs at the recommended therapeutic dose levels. Genes for resistance appear to be present in many of the important pathogenic nematodes of ruminants and horses. Under intensive management systems, where heavy reliance is placed on anthelmintic drugs for worm control, the selection of resistant genotypes may result in increased reports of the drugs failing to control the nematode populations against which they are aimed. Anthelmintic resistance has been reported from many parts of the world, and in some countries multiple drug-resistant strains have emerged. In the UK, recent investigations indicate an increasing level of resistance to benzimidazoles among nematodes of sheep and horses. The incidence, diagnosis, epidemiology and implications of anthelmintic resistance are discussed.
Asunto(s)
Antihelmínticos/farmacología , Nematodos/efectos de los fármacos , Infecciones por Nematodos/veterinaria , Animales , Antihelmínticos/uso terapéutico , Bencimidazoles/farmacología , Bencimidazoles/uso terapéutico , Resistencia a Medicamentos/genética , Caballos/parasitología , Nematodos/genética , Infecciones por Nematodos/tratamiento farmacológico , Ovinos/parasitología , Reino UnidoRESUMEN
A survey in 1992 showed that 44 per cent of the sheep farms tested in the south west and 15 per cent of those in the north east of England had parasitic nematode worm burdens which were resistant to benzimidazole anthelmintics, and that 65 per cent of the non-dairy goat farms tested in England and Wales had resistant worms. Ostertagia circumcincta was the main species in sheep and Haemonchus contortus in goats. The resistance to benzimidazoles was diagnosed by a combination of an egg hatch assay and a larval development test. A simplified faecal egg count reduction test was used to investigate sheep and goat farms for signs of ivermectin resistance but no positive cases were detected. The initial identification of levamisole resistance on one farm, both from a faecal egg count reduction test and a positive larval development test, was confirmed by a 'dose and slaughter' trial.
Asunto(s)
Antihelmínticos/uso terapéutico , Bencimidazoles/uso terapéutico , Cabras/parasitología , Hemoncosis/veterinaria , Ivermectina/uso terapéutico , Ostertagiasis/veterinaria , Ovinos/parasitología , Animales , Brotes de Enfermedades/veterinaria , Resistencia a Medicamentos , Inglaterra/epidemiología , Heces/parasitología , Hemoncosis/tratamiento farmacológico , Hemoncosis/epidemiología , Ostertagiasis/tratamiento farmacológico , Ostertagiasis/epidemiología , Prevalencia , Gales/epidemiologíaRESUMEN
On five farms identified by in vitro tests to have benzimidazole resistance, and on one farm with apparent anthelmintic failure, faecal egg count reduction tests were performed using benzimidazoles, levamisole and ivermectin. With benzimidazoles efficacy was less than 70 per cent on all farms, confirming the validity of the in vitro tests to detect benzimidazole resistance. On two farms levamisole had an efficacy of less than 90 per cent but laboratory tests failed to demonstrate levamisole resistance. Ivermectin reduced egg counts by 100 per cent on all farms.
Asunto(s)
Antihelmínticos/uso terapéutico , Heces/parasitología , Hemoncosis/veterinaria , Ostertagiasis/veterinaria , Recuento de Huevos de Parásitos/veterinaria , Enfermedades de las Ovejas/parasitología , Animales , Antihelmínticos/farmacología , Bencimidazoles/farmacología , Bencimidazoles/uso terapéutico , Resistencia a Medicamentos , Inglaterra , Hemoncosis/parasitología , Haemonchus/efectos de los fármacos , Ivermectina/farmacología , Ivermectina/uso terapéutico , Levamisol/farmacología , Levamisol/uso terapéutico , Ostertagia/efectos de los fármacos , Ostertagiasis/parasitología , Reproducibilidad de los Resultados , OvinosRESUMEN
The effectiveness of clean grazing systems for controlling the sheep abomasal parasite Haemonchus contortus under experimental conditions was monitored for a grazing season in ewes and lambs carrying either benzimidazole-susceptible or resistant populations of the parasite. Both preventive and evasive strategies failed to give effective control of H contortus. Lambs grazing with ewes that had received no anthelmintic showed clinical signs of haemonchosis by early July. Lambs from ewes dosed with a benzimidazole (mebendazole) before turn out, developed clinical signs of haemonchosis later in the season. The presence of anthelmintic resistant genotypes had a significant effect on the appearance of clinical signs, and on the epidemiology and control of disease. It was concluded that alternative worm control strategies will be required for the effective control of H contortus in the United Kingdom.
Asunto(s)
Abomaso , Crianza de Animales Domésticos , Hemoncosis/veterinaria , Enfermedades de las Ovejas/prevención & control , Gastropatías/veterinaria , Animales , Bencimidazoles/uso terapéutico , Resistencia a Medicamentos , Heces/parasitología , Femenino , Hemoncosis/parasitología , Hemoncosis/prevención & control , Recuento de Huevos de Parásitos/veterinaria , Ovinos , Enfermedades de las Ovejas/parasitología , Gastropatías/parasitología , Gastropatías/prevención & control , Factores de Tiempo , Reino UnidoRESUMEN
Two trials involving a total of 36 Dorset horn lambs were conducted to assess the anthelmintic efficacy of ivermectin against experimental infections of benzimidazole-resistant strains of Haemonchus contortus and Ostertagia circumcincta. Two resistant strains of each of the two species were used and in each trial the lambs were allocated to three groups. One group was given 200 micrograms ivermectin/kg bodyweight orally, the second group was given 5 mg oxfendazole/kg bodyweight orally and the third group remained untreated as controls. Fourteen days after treatment the lambs were necropsied. Ivermectin was found to be more than 99 per cent to 100 per cent effective against all four benzimidazole-resistant strains, whereas oxfendazole was 78.6 per cent and 83.8 per cent effective against the H contortus strains, and 25.6 per cent and 39.8 per cent effective against the O circumcincta strains.
Asunto(s)
Bencimidazoles/farmacología , Haemonchus/efectos de los fármacos , Ivermectina/farmacología , Ostertagia/efectos de los fármacos , Animales , Resistencia a Medicamentos , Hemoncosis/tratamiento farmacológico , Hemoncosis/etiología , Masculino , Ostertagiasis/tratamiento farmacológico , Ostertagiasis/etiología , Recuento de Huevos de Parásitos/veterinaria , OvinosRESUMEN
The strategic use of anthelmintics in the control of infections of Haemonchus contortus in ewes and lambs, was investigated in a series of paddock trials. The levels of infection and clinical signs associated with the presence of either benzimidazole-resistant or benzimidazole-susceptible strains of H contortus in lambs were controlled by regular drenching with levamisole or mebendazole, respectively, or by the strategic use of closantel in combination with mebendazole. In the latter case, control was achieved by dosing either the ewes in the early part of the grazing season, or the lambs from June onwards. It was concluded that worm control strategies based on closantel could provide effective control of both benzimidazole-susceptible and benzimidazole-resistant strains of H contortus on farms in the United Kingdom.
Asunto(s)
Antihelmínticos/uso terapéutico , Hemoncosis/veterinaria , Enfermedades de las Ovejas/prevención & control , Animales , Antihelmínticos/administración & dosificación , Quimioterapia Combinada , Heces/parasitología , Femenino , Hemoncosis/prevención & control , Levamisol/administración & dosificación , Levamisol/uso terapéutico , Mebendazol/administración & dosificación , Mebendazol/uso terapéutico , Recuento de Huevos de Parásitos/veterinaria , Lluvia , Salicilanilidas/administración & dosificación , Salicilanilidas/uso terapéutico , Ovinos , Temperatura , Reino Unido , Aumento de PesoRESUMEN
Faecal samples were collected from 209 randomly selected sheep farms in southern England, and the nematode eggs extracted were tested by an egg hatch assay and by a larval development test for their resistance to benzimidazoles. Benzimidazole resistance was found on 35 per cent of farms tested in East Sussex, 44 per cent in Oxfordshire and 61 per cent in West Sussex.
Asunto(s)
Bencimidazoles/farmacología , Nematodos/efectos de los fármacos , Infecciones por Nematodos/veterinaria , Enfermedades de las Ovejas/parasitología , Animales , Resistencia a Medicamentos , Inglaterra , Heces/parasitología , Larva/efectos de los fármacos , Infecciones por Nematodos/parasitología , OvinosRESUMEN
Each year, more than 167 million pigs in the European Union (EU) are tested for Trichinella spp. under the current meat hygiene regulations. This imposes large economic costs on countries, yet the vast majority of these pigs test negative and the public health risk in many countries is therefore considered very low. This work reviewed the current Trichinella status across the EU as well as the national level of monitoring and reporting. It also reviewed which animal species were affected by Trichinella and in which species it should be surveyed. This information was used to design a cost-effective surveillance programme that enables a standardised monitoring approach within the EU. The proposed surveillance programme relies on identifying sub-populations of animals with a distinct risk. Low-risk pigs are finisher pigs that originate from so-called controlled housing. All other pigs are considered high-risk pigs. Controlled housing is identified by the application of a specific list of management and husbandry practices. We suggest that member states (MS) be categorised into three classes based on the confidence that Trichinella can be considered absent, in the specified sub-population of pigs above a specified design prevalence which we set to 1 per million pigs. A simple and transparent method is proposed to estimate this confidence, based on the sensitivity of the surveillance system, taking into account the sensitivity of testing and the design prevalence. The probability of detecting a positive case, if present, must be high (>95 or >99%) to ensure that there is a low or negligible risk of transmission to humans through the food chain. In MS where the probability of a positive pig is demonstrated to be negligible, testing of fattening pigs from a sub-population consisting of pigs from controlled housing can be considered unnecessary. Furthermore, reduced testing of finishers from the sub-population consisting of pigs from non-controlled housing might even be considered, if conducted in conjunction with a proportionate sampling scheme and a risk-based wildlife surveillance programme where applicable. The proposed surveillance programme specifies the required number of samples to be taken and found negative, in a MS. A MS with no data or positive findings will initially be allocated to class 1, in which all pigs should be tested. When a MS is able to demonstrate a 95% or 99% confidence that Trichinella is absent, the MS will be allocated to class 2 or 3, in which the testing requirement is lower than in class 1.