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1.

Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Burrows, Natalie; Bashford-Rogers, Rachael J M; Bhute, Vijesh J; Peñalver, Ana; Ferdinand, John R; Stewart, Benjamin J; Smith, Joscelin E G; Deobagkar-Lele, Mukta; Giudice, Girolamo; Connor, Thomas M; Inaba, Akimichi; Bergamaschi, Laura; Smith, Sam; Tran, Maxine G B; Petsalaki, Evangelia; Lyons, Paul A; Espeli, Marion; Huntly, Brian J P; Smith, Kenneth G C; Cornall, Richard J; Clatworthy, Menna R; Maxwell, Patrick H.

Nat Immunol; 21(11): 1408-1420, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32868930

2.

Author Correction: Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development.

Burrows, Natalie; Bashford-Rogers, Rachael J M; Bhute, Vijesh J; Peñalver, Ana; Ferdinand, John R; Stewart, Benjamin J; Smith, Joscelin E G; Deobagkar-Lele, Mukta; Giudice, Girolamo; Connor, Thomas M; Inaba, Akimichi; Bergamaschi, Laura; Smith, Sam; Tran, Maxine G B; Petsalaki, Evangelia; Lyons, Paul A; Espeli, Marion; Huntly, Brian J P; Smith, Kenneth G C; Cornall, Richard J; Clatworthy, Menna R; Maxwell, Patrick H.

Nat Immunol; 22(11): 1465, 2021 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34522040

3.

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia.

Agrawal-Singh, Shuchi; Bagri, Jaana; Giotopoulos, George; Azazi, Dhoyazan M A; Horton, Sarah J; Lopez, Cecile K; Anand, Shubha; Bach, Anne-Sophie; Stedham, Frances; Antrobus, Robin; Houghton, Jack W; Vassiliou, George S; Sasca, Daniel; Yun, Haiyang; Whetton, Anthony D; Huntly, Brian J P.

Blood; 141(14): 1737-1754, 2023 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-36577137

4.

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.

Anderson, Georgina S F; Ballester-Beltran, Jose; Giotopoulos, George; Guerrero, Jose A; Surget, Sylvanie; Williamson, James C; So, Tsz; Bloxham, David; Aubareda, Anna; Asby, Ryan; Walker, Ieuan; Jenkinson, Lesley; Soilleux, Elizabeth J; Roy, James P; Teodósio, Ana; Ficken, Catherine; Officer-Jones, Leah; Nasser, Sara; Skerget, Sheri; Keats, Jonathan J; Greaves, Peter; Tai, Yu-Tzu; Anderson, Kenneth C; MacFarlane, Marion; Thaventhiran, James E; Huntly, Brian J P; Lehner, Paul J; Chapman, Michael A.

Blood; 139(16): 2471-2482, 2022 04 21.

Artículo en Inglés | MEDLINE | ID: mdl-35134130

5.

Population dynamics of normal human blood inferred from somatic mutations.

Lee-Six, Henry; Øbro, Nina Friesgaard; Shepherd, Mairi S; Grossmann, Sebastian; Dawson, Kevin; Belmonte, Miriam; Osborne, Robert J; Huntly, Brian J P; Martincorena, Inigo; Anderson, Elizabeth; O'Neill, Laura; Stratton, Michael R; Laurenti, Elisa; Green, Anthony R; Kent, David G; Campbell, Peter J.

Nature; 561(7724): 473-478, 2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-30185910

6.

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

Sasca, Daniel; Yun, Haiyang; Giotopoulos, George; Szybinski, Jakub; Evan, Theo; Wilson, Nicola K; Gerstung, Moritz; Gallipoli, Paolo; Green, Anthony R; Hills, Robert; Russell, Nigel; Osborne, Cameron S; Papaemmanuil, Elli; Göttgens, Berthold; Campbell, Peter; Huntly, Brian J P.

Blood; 134(24): 2195-2208, 2019 12 12.

Artículo en Inglés | MEDLINE | ID: mdl-31515253

7.

BET inhibitor resistance emerges from leukaemia stem cells.

Fong, Chun Yew; Gilan, Omer; Lam, Enid Y N; Rubin, Alan F; Ftouni, Sarah; Tyler, Dean; Stanley, Kym; Sinha, Devbarna; Yeh, Paul; Morison, Jessica; Giotopoulos, George; Lugo, Dave; Jeffrey, Philip; Lee, Stanley Chun-Wei; Carpenter, Christopher; Gregory, Richard; Ramsay, Robert G; Lane, Steven W; Abdel-Wahab, Omar; Kouzarides, Tony; Johnstone, Ricky W; Dawson, Sarah-Jane; Huntly, Brian J P; Prinjha, Rab K; Papenfuss, Anthony T; Dawson, Mark A.

Nature; 525(7570): 538-42, 2015 Sep 24.

Artículo en Inglés | MEDLINE | ID: mdl-26367796

8.

Glutaminolysis is a metabolic dependency in FLT3^ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Gallipoli, Paolo; Giotopoulos, George; Tzelepis, Konstantinos; Costa, Ana S H; Vohra, Shabana; Medina-Perez, Paula; Basheer, Faisal; Marando, Ludovica; Di Lisio, Lorena; Dias, Joao M L; Yun, Haiyang; Sasca, Daniel; Horton, Sarah J; Vassiliou, George; Frezza, Christian; Huntly, Brian J P.

Blood; 131(15): 1639-1653, 2018 04 12.

Artículo en Inglés | MEDLINE | ID: mdl-29463564

9.

Molecular Landscape of Acute Myeloid Leukemia: Prognostic and Therapeutic Implications.

Marando, Ludovica; Huntly, Brian J P.

Curr Oncol Rep; 22(6): 61, 2020 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-32476069

10.

Novel epigenetic therapies in hematological malignancies: Current status and beyond.

Gallipoli, Paolo; Huntly, Brian J P.

Semin Cancer Biol; 51: 198-210, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-28782607

11.

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance.

Grimwade, David; Ivey, Adam; Huntly, Brian J P.

Blood; 127(1): 29-41, 2016 Jan 07.

Artículo en Inglés | MEDLINE | ID: mdl-26660431

12.

CML: new tools to answer old questions.

Giotopoulos, George; Huntly, Brian J P.

Blood; 135(26): 2327-2328, 2020 06 25.

Artículo en Inglés | MEDLINE | ID: mdl-32585023

13.

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson, Mark A; Prinjha, Rab K; Dittmann, Antje; Giotopoulos, George; Bantscheff, Marcus; Chan, Wai-In; Robson, Samuel C; Chung, Chun-wa; Hopf, Carsten; Savitski, Mikhail M; Huthmacher, Carola; Gudgin, Emma; Lugo, Dave; Beinke, Soren; Chapman, Trevor D; Roberts, Emma J; Soden, Peter E; Auger, Kurt R; Mirguet, Olivier; Doehner, Konstanze; Delwel, Ruud; Burnett, Alan K; Jeffrey, Phillip; Drewes, Gerard; Lee, Kevin; Huntly, Brian J P; Kouzarides, Tony.

Nature; 478(7370): 529-33, 2011 Oct 02.

Artículo en Inglés | MEDLINE | ID: mdl-21964340

14.

The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

Pellicano, Francesca; Scott, Mary T; Helgason, G Vignir; Hopcroft, Lisa E M; Allan, Elaine K; Aspinall-O'Dea, Mark; Copland, Mhairi; Pierce, Andrew; Huntly, Brian J P; Whetton, Anthony D; Holyoake, Tessa L.

Stem Cells; 32(9): 2324-37, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-24806995

15.

FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia.

Lee, Benjamin H; Tothova, Zuzana; Levine, Ross L; Anderson, Kristina; Buza-Vidas, Natalija; Cullen, Dana E; McDowell, Elizabeth P; Adelsperger, Jennifer; Fröhling, Stefan; Huntly, Brian J P; Beran, Miloslav; Jacobsen, Sten Eirik; Gilliland, D Gary.

Cancer Cell; 12(4): 367-80, 2007 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-17936561

16.

Leukaemia stem cells and the evolution of cancer-stem-cell research.

Huntly, Brian J P; Gilliland, D Gary.

Nat Rev Cancer; 5(4): 311-21, 2005 04.

Artículo en Inglés | MEDLINE | ID: mdl-15803157

17.

Integrated functional genomic screening to bypass TKI resistance in chronic myeloid leukemia.

Beinortas, Tumas; Huntly, Brian J P.

Cell Rep Med; 5(5): 101565, 2024 May 21.

Artículo en Inglés | MEDLINE | ID: mdl-38776875

18.

Increased basal intracellular signaling patterns do not correlate with JAK2 genotype in human myeloproliferative neoplasms.

Anand, Shubha; Stedham, Frances; Gudgin, Emma; Campbell, Peter; Beer, Philip; Green, Anthony R; Huntly, Brian J P.

Blood; 118(6): 1610-21, 2011 Aug 11.

Artículo en Inglés | MEDLINE | ID: mdl-21653937

19.

Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms.

Anand, Shubha; Stedham, Frances; Beer, Philip; Gudgin, Emma; Ortmann, Christina A; Bench, Anthony; Erber, Wendy; Green, Anthony R; Huntly, Brian J P.

Blood; 118(1): 177-81, 2011 Jul 07.

Artículo en Inglés | MEDLINE | ID: mdl-21562050

20.

Hematopoietic stem cells made BETter by inhibition.