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1.

Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR.

Xu, Haineng; George, Erin; Gallo, David; Medvedev, Sergey; Wang, Xiaolei; Kryczka, Rosie; Hyer, Marc L; Fourtounis, Jimmy; Stocco, Rino; Aguado-Fraile, Elia; Petrone, Adam; Yin, Shou Yun; Shiwram, Ariya; Anderson, Matthew; Kim, Hyoung; Liu, Fang; Marshall, C Gary; Simpkins, Fiona.

Res Sq; 2024 Feb 16.

Artículo en Inglés | MEDLINE | ID: mdl-38410486

2.

PKMYT1 is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer.

Chen, Anran; Kim, Beom-Jun; Mitra, Aparna; Vollert, Craig T; Lei, Jonathan T; Fandino, Diana; Anurag, Meenakshi; Holt, Matthew V; Gou, Xuxu; Pilcher, Jacob B; Goetz, Matthew P; Northfelt, Donald W; Hilsenbeck, Susan G; Marshall, C Gary; Hyer, Marc L; Papp, Robert; Yin, Shou-Yun; De Angelis, Carmine; Schiff, Rachel; Fuqua, Suzanne A W; Ma, Cynthia X; Foulds, Charles E; Ellis, Matthew J.

Mol Cancer Ther; 2024 May 23.

Artículo en Inglés | MEDLINE | ID: mdl-38781103

3.

Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.

Chuntova, Pavlina; Yamamichi, Akane; Chen, Tiffany; Narayanaswamy, Rohini; Ronseaux, Sebastien; Hudson, Christine; Tron, Adriana E; Hyer, Marc L; Montoya, Megan; Mende, Abigail L; Nejo, Takahide; Downey, Kira M; Diebold, David; Lu, Min; Nicolay, Brandon; Okada, Hideho.

J Immunother Cancer; 10(5)2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35606087

4.

Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.

Li, Mingzong; Konteatis, Zenon; Nagaraja, Nelamangala; Chen, Yue; Zhou, Shubao; Ma, Guangning; Gross, Stefan; Marjon, Katya; Hyer, Marc L; Mandley, Everton; Lein, Max; Padyana, Anil K; Jin, Lei; Tong, Shuilong; Peters, Rachel; Murtie, Joshua; Travins, Jeremy; Medeiros, Matthew; Liu, Peng; Frank, Victoria; Judd, Evan T; Biller, Scott A; Marks, Kevin M; Sui, Zhihua; Reznik, Samuel K.

J Med Chem; 65(6): 4600-4615, 2022 03 24.

Artículo en Inglés | MEDLINE | ID: mdl-35293760

5.

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells.

Gruber, Emily; So, Joan; Lewis, Alexander C; Franich, Rheana; Cole, Rachel; Martelotto, Luciano G; Rogers, Amy J; Vidacs, Eva; Fraser, Peter; Stanley, Kym; Jones, Lisa; Trigos, Anna; Thio, Niko; Li, Jason; Nicolay, Brandon; Daigle, Scott; Tron, Adriana E; Hyer, Marc L; Shortt, Jake; Johnstone, Ricky W; Kats, Lev M.

Cell Rep; 40(7): 111182, 2022 08 16.

Artículo en Inglés | MEDLINE | ID: mdl-35977494

6.

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.

Konteatis, Zenon; Travins, Jeremy; Gross, Stefan; Marjon, Katya; Barnett, Amelia; Mandley, Everton; Nicolay, Brandon; Nagaraja, Raj; Chen, Yue; Sun, Yabo; Liu, Zhixiao; Yu, Jie; Ye, Zhixiong; Jiang, Fan; Wei, Wentao; Fang, Cheng; Gao, Yi; Kalev, Peter; Hyer, Marc L; DeLaBarre, Byron; Jin, Lei; Padyana, Anil K; Dang, Lenny; Murtie, Joshua; Biller, Scott A; Sui, Zhihua; Marks, Kevin M.

J Med Chem; 64(8): 4430-4449, 2021 04 22.

Artículo en Inglés | MEDLINE | ID: mdl-33829783

7.

MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.

Kalev, Peter; Hyer, Marc L; Gross, Stefan; Konteatis, Zenon; Chen, Chi-Chao; Fletcher, Mark; Lein, Max; Aguado-Fraile, Elia; Frank, Victoria; Barnett, Amelia; Mandley, Everton; Goldford, Joshua; Chen, Yue; Sellers, Katie; Hayes, Sebastian; Lizotte, Kate; Quang, Phong; Tuncay, Yesim; Clasquin, Michelle; Peters, Rachel; Weier, Jaclyn; Simone, Eric; Murtie, Joshua; Liu, Wei; Nagaraja, Raj; Dang, Lenny; Sui, Zhihua; Biller, Scott A; Travins, Jeremy; Marks, Kevin M; Marjon, Katya.

Cancer Cell; 39(2): 209-224.e11, 2021 02 08.

Artículo en Inglés | MEDLINE | ID: mdl-33450196

8.

Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections.

Krajewska, Maryla; Smith, Layton H; Rong, Juan; Huang, Xianshu; Hyer, Marc L; Zeps, Nikolajs; Iacopetta, Barry; Linke, Steven P; Olson, Allen H; Reed, John C; Krajewski, Stan.

J Histochem Cytochem; 57(7): 649-63, 2009 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-19289554

9.

Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.

Barghout, Samir H; Patel, Parasvi S; Wang, Xiaoming; Xu, G Wei; Kavanagh, Simon; Halgas, Ondrej; Zarabi, Sara F; Gronda, Marcela; Hurren, Rose; Jeyaraju, Danny V; MacLean, Neil; Brennan, Shawn; Hyer, Marc L; Berger, Allison; Traore, Tary; Milhollen, Michael; Smith, Adam C; Minden, Mark D; Pai, Emil F; Hakem, Razq; Schimmer, Aaron D.

Leukemia; 33(1): 37-51, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-29884901

10.

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

Hyer, Marc L; Milhollen, Michael A; Ciavarri, Jeff; Fleming, Paul; Traore, Tary; Sappal, Darshan; Huck, Jessica; Shi, Judy; Gavin, James; Brownell, Jim; Yang, Yu; Stringer, Bradley; Griffin, Robert; Bruzzese, Frank; Soucy, Teresa; Duffy, Jennifer; Rabino, Claudia; Riceberg, Jessica; Hoar, Kara; Lublinsky, Anya; Menon, Saurabh; Sintchak, Michael; Bump, Nancy; Pulukuri, Sai M; Langston, Steve; Tirrell, Stephen; Kuranda, Mike; Veiby, Petter; Newcomb, John; Li, Ping; Wu, Jing Tao; Powe, Josh; Dick, Lawrence R; Greenspan, Paul; Galvin, Katherine; Manfredi, Mark; Claiborne, Chris; Amidon, Benjamin S; Bence, Neil F.

Nat Med; 24(2): 186-193, 2018 02.

Artículo en Inglés | MEDLINE | ID: mdl-29334375

11.

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells.

Hyer, Marc L; Croxton, Rhonda; Krajewska, Maryla; Krajewski, Stanislaw; Kress, Christina L; Lu, Meiling; Suh, Nanjoo; Sporn, Michael B; Cryns, Vincent L; Zapata, Juan M; Reed, John C.

Cancer Res; 65(11): 4799-808, 2005 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-15930300

12.

In vitro efficacy of Fas ligand gene therapy for the treatment of bladder cancer.

Sudarshan, Sunil; Holman, David H; Hyer, Marc L; Voelkel-Johnson, Christina; Dong, Jian-Yun; Norris, James S.

Cancer Gene Ther; 12(1): 12-8, 2005 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-15514684

13.

Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression.

Hyer, Marc L; Sudarshan, Sunil; Schwartz, David A; Hannun, Yusuf; Dong, Jian-yun; Norris, James S.

Cancer Gene Ther; 10(4): 330-9, 2003 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-12679806

14.

Downregulation of c-FLIP sensitizes DU145 prostate cancer cells to Fas-mediated apoptosis.

Hyer, Marc L; Sudarshan, Sunil; Kim, Youngsoo; Reed, John C; Dong, Jian-yun; Schwartz, David A; Norris, James S.

Cancer Biol Ther; 1(4): 401-6, 2002.

Artículo en Inglés | MEDLINE | ID: mdl-12432255

15.

Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines.

Driscoll, Denise L; Chakravarty, Arijit; Bowman, Doug; Shinde, Vaishali; Lasky, Kerri; Shi, Judy; Vos, Tricia; Stringer, Bradley; Amidon, Ben; D'Amore, Natalie; Hyer, Marc L.

PLoS One; 9(11): e111060, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-25365521

16.

Translational exposure-efficacy modeling to optimize the dose and schedule of taxanes combined with the investigational Aurora A kinase inhibitor MLN8237 (alisertib).

Huck, Jessica J; Zhang, Mengkun; Mettetal, Jerome; Chakravarty, Arijit; Venkatakrishnan, Karthik; Zhou, Xiaofei; Kleinfield, Rob; Hyer, Marc L; Kannan, Karuppiah; Shinde, Vaishali; Dorner, Andy; Manfredi, Mark G; Shyu, Wen Chyi; Ecsedy, Jeffrey A.

Mol Cancer Ther; 13(9): 2170-83, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-24980948

17.

The FLIP-side of Fas signaling.

Hyer, Marc L; Samuel, Temesgen; Reed, John C.

Clin Cancer Res; 12(20 Pt 1): 5929-31, 2006 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-17028246

18.

MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma.

Shi, Judy Quiju; Lasky, Kerri; Shinde, Vaishali; Stringer, Bradley; Qian, Mark G; Liao, Debra; Liu, Ray; Driscoll, Denise; Nestor, Michelle Tighe; Amidon, Benjamin S; Rao, Youlan; Duffey, Matt O; Manfredi, Mark G; Vos, Tricia J; D' Amore, Natalie; Hyer, Marc L.

Mol Cancer Ther; 11(9): 2045-53, 2012 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-22609854

19.

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Duffey, Matthew O; Vos, Tricia J; Adams, Ruth; Alley, Jennifer; Anthony, Justin; Barrett, Cynthia; Bharathan, Indu; Bowman, Douglas; Bump, Nancy J; Chau, Ryan; Cullis, Courtney; Driscoll, Denise L; Elder, Amy; Forsyth, Nancy; Frazer, Jonathan; Guo, Jianping; Guo, Luyi; Hyer, Marc L; Janowick, David; Kulkarni, Bheemashankar; Lai, Su-Jen; Lasky, Kerri; Li, Gang; Li, Jing; Liao, Debra; Little, Jeremy; Peng, Bo; Qian, Mark G; Reynolds, Dominic J; Rezaei, Mansoureh; Scott, Margaret Porter; Sells, Todd B; Shinde, Vaishali; Shi, Qiuju Judy; Sintchak, Michael D; Soucy, Francois; Sprott, Kevin T; Stroud, Stephen G; Nestor, Michelle; Visiers, Irache; Weatherhead, Gabriel; Ye, Yingchun; D'Amore, Natalie.

J Med Chem; 55(1): 197-208, 2012 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-22070629

20.

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.

Manfredi, Mark G; Ecsedy, Jeffrey A; Chakravarty, Arijit; Silverman, Lee; Zhang, Mengkun; Hoar, Kara M; Stroud, Stephen G; Chen, Wei; Shinde, Vaishali; Huck, Jessica J; Wysong, Deborah R; Janowick, David A; Hyer, Marc L; Leroy, Patrick J; Gershman, Rachel E; Silva, Matthew D; Germanos, Melissa S; Bolen, Joseph B; Claiborne, Christopher F; Sells, Todd B.

Clin Cancer Res; 17(24): 7614-24, 2011 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-22016509

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