RESUMEN
OBJECTIVE: Hepatitis C virus (HCV) infection is a major public health problem that causes multiple comorbidities. People in prisons who inject intravenous drugs are at increased risk of HCV infection, and HCV infection is 15-fold more prevalent among prisoners compared with the community. The objective of this study was to analyse the clinical and epidemiological characteristics of residents of a Spanish prison with HCV infection who received antiviral treatment. METHODS: An observational, descriptive and retrospective study was performed. All patients with HCV infection diagnosed or followed up in an Infectious Diseases attached to a penitentiary were included in this study. RESULTS: Of 81 patients analysed, sixty-nine (83.1%) patients were male. The mean age was 50.1 (SD8.8) years, and 70% of the inmates had a history of injection drug use. Coinfection with HIV was detected in 30%. In up to 25% of the sample, there were data on chronic liver disease in the degree of liver cirrhosis. The diagnosis of HCV infection had been made more than 15 years earlier in 28% of those studied. Decompensations from liver disease, hepatocellular carcinoma, or hospital admissions were exceptional. Most of the inmates with HCV accepted treatment, and approximately 94% of the patients who completed treatment achieved a sustained virological response without interactions or complications of interest. CONCLUSIONS: The availability of direct-acting antivirals and their exceptional side effects constitute an opportunity to reduce the burden of HCV infection in Spain, particularly in these high-risk populations.
Asunto(s)
Hepatitis C Crónica , Hepatitis C , Antivirales/uso terapéutico , Femenino , Hepacivirus , Hepatitis C/complicaciones , Hepatitis C/tratamiento farmacológico , Hepatitis C/epidemiología , Hepatitis C Crónica/tratamiento farmacológico , Hepatitis C Crónica/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Prisiones , Estudios RetrospectivosAsunto(s)
Trasplante de Riñón , Complicaciones Posoperatorias/diagnóstico , Tuberculoma Intracraneal/diagnóstico , Tuberculosis Laríngea/diagnóstico , Adulto , Anciano , Antituberculosos/uso terapéutico , Cerebelo/microbiología , Cerebelo/patología , Femenino , Lóbulo Frontal/microbiología , Lóbulo Frontal/patología , Humanos , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Inmunosupresores/uso terapéutico , Tuberculosis Latente/diagnóstico , Masculino , Lóbulo Occipital/microbiología , Lóbulo Occipital/patología , Riñón Poliquístico Autosómico Recesivo/cirugía , Tuberculoma Intracraneal/etiología , Tuberculosis Laríngea/etiología , Tuberculosis Pulmonar/complicacionesRESUMEN
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