1.
J Org Chem
; 85(6): 4525-4529, 2020 03 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32069399
RESUMEN
Asymmetric List-Mannich reactions were carried out in the frozen state to afford optically active adducts in moderate-to-good chemical yields and enantiomeric excesses (ee). The frozen solution exerts critical control of ee via entropy changes, in sharp contrast to the enthalpy-driven asymmetric reactions typically observed in homogeneous solvents. This study provides new perspectives for asymmetric syntheses and an attractive alternative to conventional media.