Case of Amaurosis Fugax in the Setting of a Persistent Primitive Hypoglossal Artery Requiring Carotid Endarterectomy with Regional Anesthesia.

BACKGROUND A persistent primitive hypoglossal artery (PPHA) is a rare congenital anomaly leading to persistent carotid-basilar anastomosis. This is a report of an 83-year-old man with a PPHA presenting with amaurosis fugax of the left eye requiring carotid endarterectomy under regional anesthesia. CASE REPORT An 83-year-old man presented with 2 weeks of intermittent self-resolving visual disturbances, followed by an episode of left eye amaurosis fugax. The patient had been referred to the hospital for further investigation of symptoms 1 day following the amaurosis fugax event. Carotid Doppler ultrasound demonstrated a greater than 90% stenosis of the left internal carotid artery. Computed tomography carotid and Circle of Willis angiography confirmed a mixed, ulcerated plaque and revealed a persistent left hypoglossal artery originating from the left internal carotid artery and continuing as the basilar artery. On day 3 of admission, left carotid endarterectomy was performed under conscious sedation and regional anesthesia to permit continuous monitoring of neurological status and avoid the need for intraoperative shunting. "Permissive hypertension" by targeting a systolic blood pressure of 190 to 200 mmHg was sought for the duration of clamp time. There was no deterioration of neurological function during clamping of the carotid vessels. The patient recovered well and was discharged 2 days after surgery, with no residual neurology. CONCLUSIONS This report has presented a rare case of PPHA to highlight awareness of this congenital vascular anomaly when undertaking carotid endarterectomy.

Detecting awareness in children by using an auditory intervention.

BACKGROUND: The incidence of awareness has been reported to be higher in children than in adults. Accurately assessing awareness in children is difficult, and the lack of a specific measure of awareness makes it difficult to determine exactly how many and why children are aware. The aim of this study was to determine the incidence and timing of awareness in children by using auditory stimuli applied during anesthesia. METHODS: Three easily identified animal noises were played repeatedly through headphones during three specific phases of anesthesia in 539 children aged 5-12 yr. Children were not told that this would happen. Awareness was determined with a structured interview on days 1 and 3 after the anesthetic. All positive responses were sent to four adjudicators for assessment, and awareness was defined as having occurred if all adjudicators agreed that the child was aware. RESULTS: Five hundred children were interviewed at least once after the anesthetic. Thirty-five reports were sent to the adjudicators, and one child was classified as aware. This child was deemed to be aware even though he did not report hearing an animal. CONCLUSIONS: The incidence of awareness in this study is less than reported previously.

Focused Cardiac Ultrasound Determines Cause of Cardiovascular Collapse During Thoracic Surgery in a Patient With Undiagnosed Pulmonary Hypertension: A Case Report.

Patients with severe pulmonary hypertension (PHT) represent a high-risk population when undergoing noncardiac surgery. During thoracic surgery with 1-lung ventilation, atelectasis of the operative lung, and frequently associated hypoxemia, is likely to exacerbate PHT and precipitate acute right ventricular failure. We present a patient with previously undiagnosed PHT who suffered 2 cardiac arrests during emergent thoracic surgery for empyema. After successful resuscitation in the operating room, she subsequently required prolonged venoarterial extracorporeal membrane oxygenation. Focused transthoracic echocardiography to evaluate cardiac function was critical in the diagnosis of PHT and subsequent treatment with sildenafil and nifedipine when discharged from the hospital.

Are patients satisfied after peripheral nerve blockade? Results from an International Registry of Regional Anesthesia.

INTRODUCTION: Peripheral nerve blockade (PNB) is associated with superior outcomes compared with opioids; however, little is known regarding patients' perceptions of the care they have received. Patient satisfaction is emerging as an important indicator of quality of health care, and identifying deficiencies in discrete aspects of satisfaction may allow targeted interventions to improve quality. In this study, we analyze data relevant to patient satisfaction from the International Registry of Regional Anesthesia. The primary objective of this analysis was to report the results of a patient-satisfaction questionnaire and to determine predictors associated with unwillingness to have PNB repeated in the case of future surgery. METHODS: The questionnaire used in this study was derived from this registry's results and from previously validated questionnaires and addressed 3 domains of importance, namely, provision of information, pain, and interaction with the anesthesiologist. The 11-item written, multidimensional questionnaire was given to patients within 2 days postoperatively. The primary outcome was willingness to have PNB repeated in the event of future similar surgery. RESULTS: Data related to 9969 surgical procedures were collected between July 1, 2011, and March 31, 2013. The survey response rate was 61.6%. Most respondents-94.6% (95% confidence interval, 94.0%-95.1%)--stated that they were willing to have a repeat PNB. Ninety percent of respondents were satisfied or completely satisfied with the information provided about the nerve block, as well as the anesthesiologist-patient interaction. Patients who were dissatisfied with either of these domains (ie, information provision or professional interaction) were less willing to undergo repeat PNB, as were patients who reported significant pain during the nerve block procedure. CONCLUSIONS: A high proportion of survey respondents were willing to undergo repeat PNB in case of future surgery and were satisfied with their anesthetic care. Targeted interventions to improve quality of PNB should be aimed at improving comfort, information provision, and physician-patient interaction.

AEP-monitor/2 derived, composite auditory evoked potential index (AAI-1.6) and bispectral index as predictors of sevoflurane concentration in children.

BACKGROUND: Level of anesthesia may be predicted with the auditory evoked potential or with passive processed electroencephalogram (EEG) parameters. Some previous reports suggest the passive EEG does not reliably predict level of anesthesia in infants. The AAI-1.6 is a relatively new index derived from the AEP/2 monitor. It combines auditory evoked potentials and passive EEG parameters into a single index. This study aimed to assess the AAI-1.6 as a predictor of level of anesthesia in infants and children. METHODS: Four infants aged less than 1 year, and five older children aged between 2 and 11 years were enrolled. They all had uniform sevoflurane anesthesia for cardiac catheterization. The AAI-1.6 and bispectral index (BIS) were recorded after achieving equilibrium at 1.5%, 2% and 2.5% sevoflurane, and immediately prior to awakening. The prediction coefficient (Pk) for BIS and AAI-1.6 was calculated and compared within each age group. RESULTS: The Pk for the AAI-1.6 was low in both 0-1 and 2-11 years age groups. In the 2-12 years group, the Pk for BIS was significantly higher than the Pk for the AAI-1.6 (Pk for BIS: 0.89, Pk for AAI-1.6: 0.53, P < 0.01). In contrast in the 0-1 year age group there was no evidence for a difference between the Pk for BIS and the Pk for the AAI-1.6 (Pk for BIS: 0.74, Pk for AAI-1.6: 0.53, P = 0.25). CONCLUSIONS: This preliminary study suggests AAI-1.6 is a poor predictor of sevoflurane concentration in infants and children.

The effects of caudal local anesthesia blockade on the Bispectral Index during general anesthesia in children.

BACKGROUND: Peripheral deafferentation induced by epidural or spinal anesthesia reduces the degree of cortical arousal in adults. This study aimed at determining if caudal blockade decreases the level of arousal, as measured by Bispectral Index (BIS) in unstimulated children, and to determine if this effect differed between age groups. METHODS: Hospital ethics committee approval and parental consent was obtained. Children (age between 24 months and 5 years) and infants (between 6 and 24 months of age) were recruited if they were scheduled for below umbilical surgery that would usually require caudal local anesthesia blockade. Before the procedure, subjects within each age group were randomized to either caudal group (1 ml.kg(-1) 0.25% bupivacaine), or control group (no caudal). In all groups, anesthesia was induced with sevoflurane and maintained at a constant endtidal concentration of 1.5% sevoflurane without N(2)O. Five minutes after induction a baseline BIS was recorded (BIS(1)). In the caudal groups, a caudal block was then performed while in the control groups no block was performed. Fifteen minutes later, the BIS was again recorded (BIS(2)). The change in BIS over this time period was the primary outcome (BIS(Delta)). After measurement, subjects in the control groups received a caudal block before the start of surgery. RESULTS: Twenty-nine infants and 18 children completed the study protocol. In children, BIS(Delta) was significantly different between the caudal group and control (-5.7 vs -0.7, P = 0.04). In infants, no significant difference was detected in BIS(Delta) between caudal and control groups. CONCLUSIONS: Caudal blockade decreased the degree of arousal, as measured by BIS, in unstimulated children aged 2-5 years. No change in arousal was detected in infants.