RESUMEN
BACKGROUND: To describe Doppler optical coherence tomography (OCT) imaging of ruptured retinal arterial macroaneurysms (RAMs). METHODS: Four eyes of four patients with ruptured RAMs were prospectively studied. Vascular imaging was obtained using swept-source Doppler OCT, and compared with indocyanine green angiography images. RESULTS: En face projection of Doppler OCT images clearly showed RAMs at the corresponding locations of lesions in the indocyanine green angiography images. In Doppler OCT images, RAMs were located in the inner retina in three eyes and in the medium layer of the retina in one eye. In one eye, detection of RAMs by standard OCT was difficult because of the presence of inner retinal hemorrhage. In one eye, disappearance of blood flow after direct laser photocoagulation could be confirmed by Doppler OCT images. CONCLUSIONS: Doppler OCT imaging may potentially function as a noninvasive complementary procedure with indocyanine green angiography.
Asunto(s)
Aneurisma Roto/diagnóstico , Efecto Doppler , Arteria Retiniana/patología , Hemorragia Retiniana/diagnóstico , Tomografía de Coherencia Óptica , Anciano , Anciano de 80 o más Años , Aneurisma Roto/cirugía , Colorantes , Femenino , Angiografía con Fluoresceína , Humanos , Imagenología Tridimensional , Verde de Indocianina , Coagulación con Láser , Masculino , Estudios Prospectivos , Hemorragia Retiniana/cirugíaRESUMEN
The culprit behind adult T-cell leukemia, myelopathy/tropical paraparesis, and a plethora of inflammatory diseases is the human T-cell leukemia virus type 1 (HTLV-I). We recently unveiled a potent hexapeptidic HTLV-I protease inhibitor, KNI-10166, composed mostly of natural amino acid residues. Herein, we report the derivation of potent tetrapeptidic inhibitor KNI-10516, possessing only non-natural amino acid residues.