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Biochem Soc Trans
; 44(5): 1385-1393, 2016 10 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27911721
RESUMEN
Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the 'Epitranscriptome' for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease.
Asunto(s)
Enfermedad/genética , Nucleótidos/genética , Edición de ARN , ARN Mensajero/genética , Animales , Arabidopsis/genética , Caenorhabditis elegans/genética , Drosophila melanogaster/genética , Predisposición Genética a la Enfermedad/genética , Humanos , Mutación , Saccharomyces cerevisiae/genética
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