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1.

The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.

Kim, HyeongJun; Yen, Linda; Wongpalee, Somsakul P; Kirshner, Jessica A; Mehta, Nicita; Xue, Yan; Johnston, Jonathan B; Burlingame, Alma L; Kim, John K; Loparo, Joseph J; Jacobsen, Steve E.

Mol Cell; 75(4): 700-710.e6, 2019 08 22.

Artículo en Inglés | MEDLINE | ID: mdl-31442422

2.

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

Yoon, Peter H; Skopintsev, Petr; Shi, Honglue; Chen, LinXing; Adler, Benjamin A; Al-Shimary, Muntathar; Craig, Rory J; Loi, Kenneth J; DeTurk, Evan C; Li, Zheng; Amerasekera, Jasmine; Trinidad, Marena; Nisonoff, Hunter; Chen, Kai; Lahiri, Arushi; Boger, Ron; Jacobsen, Steve; Banfield, Jillian F; Doudna, Jennifer A.

Nucleic Acids Res; 51(22): 12414-12427, 2023 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-37971304

3.

Epigenome-wide association in adipose tissue from the METSIM cohort.

Orozco, Luz D; Farrell, Colin; Hale, Christopher; Rubbi, Liudmilla; Rinaldi, Arturo; Civelek, Mete; Pan, Calvin; Lam, Larry; Montoya, Dennis; Edillor, Chantle; Seldin, Marcus; Boehnke, Michael; Mohlke, Karen L; Jacobsen, Steve; Kuusisto, Johanna; Laakso, Markku; Lusis, Aldons J; Pellegrini, Matteo.

Hum Mol Genet; 27(10): 1830-1846, 2018 05 15.

Artículo en Inglés | MEDLINE | ID: mdl-29566149

4.

Receiving Spiritual Care: Experiences of Dying and Grieving Individuals.

Bonavita, Anthony; Yakushko, Oksana; Morgan Consoli, Melissa L; Jacobsen, Steve; Mancuso, Rev Laura L.

Omega (Westport); 76(4): 373-394, 2018 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-29284323

5.

Transition of care from pre-dialysis prelude to renal replacement therapy: the blueprints of emerging research in advanced chronic kidney disease.

Kalantar-Zadeh, Kamyar; Kovesdy, Csaba P; Streja, Elani; Rhee, Connie M; Soohoo, Melissa; Chen, Joline L T; Molnar, Miklos Z; Obi, Yoshitsugu; Gillen, Daniel; Nguyen, Danh V; Norris, Keith C; Sim, John J; Jacobsen, Steve S.

Nephrol Dial Transplant; 32(suppl_2): ii91-ii98, 2017 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-28201698

6.

Epigenome-wide association in adipose tissue from the METSIM cohort.

Orozco, Luz D; Farrell, Colin; Hale, Christopher; Rubbi, Liudmilla; Rinaldi, Arturo; Civelek, Mete; Pan, Calvin; Lam, Larry; Montoya, Dennis; Edillor, Chantle; Seldin, Marcus; Boehnke, Michael; Mohlke, Karen L; Jacobsen, Steve; Kuusisto, Johanna; Laakso, Markku; Lusis, Aldons J; Pellegrini, Matteo.

Hum Mol Genet; 27(14): 2586, 2018 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-29893869

7.

The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.

Caro, Elena; Stroud, Hume; Greenberg, Maxim V C; Bernatavichute, Yana V; Feng, Suhua; Groth, Martin; Vashisht, Ajay A; Wohlschlegel, James; Jacobsen, Steve E.

PLoS Genet; 8(10): e1002995, 2012.

Artículo en Inglés | MEDLINE | ID: mdl-23071452

8.

Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1.

Sung, Sibum; He, Yuehui; Eshoo, Tifani W; Tamada, Yosuke; Johnson, Lianna; Nakahigashi, Kenji; Goto, Koji; Jacobsen, Steve E; Amasino, Richard M.

Nat Genet; 38(6): 706-10, 2006 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-16682972

9.

Intrauterine calorie restriction affects placental DNA methylation and gene expression.

Chen, Pao-Yang; Ganguly, Amit; Rubbi, Liudmilla; Orozco, Luz D; Morselli, Marco; Ashraf, Davin; Jaroszewicz, Artur; Feng, Suhua; Jacobsen, Steve E; Nakano, Atsushi; Devaskar, Sherin U; Pellegrini, Matteo.

Physiol Genomics; 45(14): 565-76, 2013 Jul 15.

Artículo en Inglés | MEDLINE | ID: mdl-23695884

10.

Research data warehouse: using electronic health records to conduct population-based observational studies.

Chen, Wansu; Xie, Fagen; Mccarthy, Don P; Reynolds, Kristi L; Lee, Mingsum; Coleman, Karen J; Getahun, Darios; Koebnick, Corinna; Jacobsen, Steve J.

JAMIA Open; 6(2): ooad039, 2023 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-37359950

11.

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

Yoon, Peter H; Skopintsev, Petr; Shi, Honglue; Chen, Lin-Xing; Adler, Benjamin A; Al-Shimary, Muntathar; Craig, Rory J; Li, Zheng; Amerasekera, Jasmine; Trinidad, Marena; Nisonoff, Hunter; Chen, Kai; Lahiri, Arushi; Boger, Ron; Jacobsen, Steve; Banfield, Jillian F; Doudna, Jennifer A.

bioRxiv; 2023 Aug 10.

Artículo en Inglés | MEDLINE | ID: mdl-37609353

12.

Plant genetics: increased outcrossing in hothead mutants.

Peng, Peng; Chan, Simon W-L; Shah, Govind A; Jacobsen, Steve E.

Nature; 443(7110): E8; discussion E8-9, 2006 Sep 28.

Artículo en Inglés | MEDLINE | ID: mdl-17006468

13.

Design and synthesis of aminohydantoins as potent and selective human ß-secretase (BACE1) inhibitors with enhanced brain permeability.

Malamas, Michael S; Robichaud, Albert; Erdei, Jim; Quagliato, Dominick; Solvibile, William; Zhou, Ping; Morris, Koi; Turner, Jim; Wagner, Erik; Fan, Kristi; Olland, Andrea; Jacobsen, Steve; Reinhart, Peter; Riddell, David; Pangalos, Menelas.

Bioorg Med Chem Lett; 20(22): 6597-605, 2010 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-20880704

14.

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

Nowak, Pawel; Cole, Derek C; Aulabaugh, Ann; Bard, Jonathan; Chopra, Rajiv; Cowling, Rebecca; Fan, Kristi Y; Hu, Baihua; Jacobsen, Steve; Jani, Minakshi; Jin, Guixan; Lo, Mei-Chu; Malamas, Michael S; Manas, Eric S; Narasimhan, Rani; Reinhart, Peter; Robichaud, Albert J; Stock, Joseph R; Subrath, Joan; Svenson, Kristine; Turner, Jim; Wagner, Erik; Zhou, Ping; Ellingboe, John W.

Bioorg Med Chem Lett; 20(2): 632-5, 2010 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-19959359

15.

A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.

Khachaturian, Zaven S; Snyder, Peter J; Doody, Rachelle; Aisen, Paul; Comer, Meryl; Dwyer, John; Frank, Richard A; Holzapfel, Andrew; Khachaturian, Ara S; Korczyn, Amos D; Roses, Allen; Simpkins, James W; Schneider, Lon S; Albert, Marilyn S; Egge, Robert; Deves, Aaron; Ferris, Steven; Greenberg, Barry D; Johnson, Carl; Kukull, Walter A; Poirier, Judes; Schenk, Dale; Thies, William; Gauthier, Serge; Gilman, Sid; Bernick, Charles; Cummings, Jeffrey L; Fillit, Howard; Grundman, Michael; Kaye, Jeff; Mucke, Lennart; Reisberg, Barry; Sano, Mary; Pickeral, Oxana; Petersen, Ronald C; Mohs, Richard C; Carrillo, Maria; Corey-Bloom, Jody P; Foster, Norman L; Jacobsen, Steve; Lee, Virginia; Potter, William Z; Sabbagh, Marwan N; Salmon, David; Trojanowski, John Q; Wexler, Nancy; Bain, Lisa J.

Alzheimers Dement; 5(2): 85-92, 2009 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-19328434

16.

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

Chadchankar, Jayashree; Korboukh, Victoria; Conway, Leslie C; Wobst, Heike J; Walker, Chandler A; Doig, Peter; Jacobsen, Steve J; Brandon, Nicholas J; Moss, Stephen J; Wang, Qi.

PLoS One; 14(11): e0225145, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31703099

17.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.

Cole, Derek C; Stock, Joseph R; Chopra, Rajiv; Cowling, Rebecca; Ellingboe, John W; Fan, Kristi Y; Harrison, Boyd L; Hu, Yun; Jacobsen, Steve; Jennings, Lee D; Jin, Guixian; Lohse, Peter A; Malamas, Michael S; Manas, Eric S; Moore, William J; O'Donnell, Mary-Margaret; Olland, Andrea M; Robichaud, Albert J; Svenson, Kristine; Wu, JunJun; Wagner, Eric; Bard, Jonathan.

Bioorg Med Chem Lett; 18(3): 1063-6, 2008 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-18162398

18.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

Jennings, Lee D; Cole, Derek C; Stock, Joseph R; Sukhdeo, Mohani N; Ellingboe, John W; Cowling, Rebecca; Jin, Guixian; Manas, Eric S; Fan, Kristi Y; Malamas, Michael S; Harrison, Boyd L; Jacobsen, Steve; Chopra, Rajiv; Lohse, Peter A; Moore, William J; O'Donnell, Mary-Margaret; Hu, Yun; Robichaud, Albert J; Turner, M James; Wagner, Erik; Bard, Jonathan.

Bioorg Med Chem Lett; 18(2): 767-71, 2008 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-18068983

19.

Acylguanidines as small-molecule beta-secretase inhibitors.

Cole, Derek C; Manas, Eric S; Stock, Joseph R; Condon, Jeffrey S; Jennings, Lee D; Aulabaugh, Ann; Chopra, Rajiv; Cowling, Rebecca; Ellingboe, John W; Fan, Kristi Y; Harrison, Boyd L; Hu, Yun; Jacobsen, Steve; Jin, Guixan; Lin, Laura; Lovering, Frank E; Malamas, Michael S; Stahl, Mark L; Strand, James; Sukhdeo, Mohani N; Svenson, Kristine; Turner, M James; Wagner, Erik; Wu, Junjun; Zhou, Ping; Bard, Jonathan.

J Med Chem; 49(21): 6158-61, 2006 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-17034121

20.

To our readers: Important notice.

Poland, Gregory A; van Dijk, Nicolette; Altmann, Danny; Borrow, Ray; Hung, Ivan; Ishii, Ken; Jacobsen, Steve; Krammer, Florian; Larson, Heidi; Lua, Linda; Middelberg, Anton; Nelson, Jennifer; Neuzil, Kathy; Nohynek, Hanna; Reingold, Art; van den Hurk, Sylvia; Kennedy, Rick B; Sadarangani, Sapna.

Vaccine; 38(35): 5563, 2020 07 31.

Artículo en Inglés | MEDLINE | ID: mdl-32654898

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The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

Epigenome-wide association in adipose tissue from the METSIM cohort.

Receiving Spiritual Care: Experiences of Dying and Grieving Individuals.

Transition of care from pre-dialysis prelude to renal replacement therapy: the blueprints of emerging research in advanced chronic kidney disease.

Epigenome-wide association in adipose tissue from the METSIM cohort.

The SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation-independent manner.

Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1.

Intrauterine calorie restriction affects placental DNA methylation and gene expression.

Research data warehouse: using electronic health records to conduct population-based observational studies.

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.

Plant genetics: increased outcrossing in hothead mutants.

Design and synthesis of aminohydantoins as potent and selective human ß-secretase (BACE1) inhibitors with enhanced brain permeability.

Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.

A roadmap for the prevention of dementia II: Leon Thal Symposium 2008.

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets.

Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

Acylguanidines as small-molecule beta-secretase inhibitors.

To our readers: Important notice.