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1.
Bromodecarboxylation of quinoline salicylic acids: increasing the diversity of accessible substituted quinolines.
J Org Chem;
74(22): 8874-7, 2009 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-19863103
2.
Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis.
J Pharmacol Exp Ther;
324(2): 497-506, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-18024786
3.
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
J Med Chem;
50(1): 21-39, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201408
4.
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
J Med Chem;
50(1): 40-64, 2007 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-17201409
5.
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
J Med Chem;
50(19): 4728-45, 2007 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17715908
6.
Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
ChemMedChem;
11(2): 217-33, 2016 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-26381330
7.
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.
J Med Chem;
48(13): 4346-57, 2005 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15974587
8.
Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
J Med Chem;
57(4): 1299-322, 2014 Feb 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24512187
9.
Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
J Med Chem;
55(11): 5088-109, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22651823
10.
Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
J Med Chem;
53(16): 6003-17, 2010 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20718494
11.
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Bioorg Med Chem;
15(19): 6425-42, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17664070
12.
Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.
Bioorg Med Chem Lett;
16(23): 6067-72, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16973359
13.
Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.
Bioorg Med Chem Lett;
15(23): 5288-92, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16165349
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