Experience of the national cohort of pregnant women with HIV and their children in Spain: temporal trends in vertical transmission of HIV and associated infections.

INTRODUCTION: The vertical transmission rate (VTR) of HIV has decreased to less than 2% in high-income countries, in spite of which perinatal infections continue to occur. We present data from the national cohort of pregnant women living with HIV and their children in Spain. The objectives were to describe the characteristics of this population, evaluate the VTR of HIV, the safety of antiretroviral therapy (ART) and the prevalence of coinfection. PATIENTS AND METHODS: Multicentre prospective, observational and descriptive study with participation of 62 hospitals. The sample included pegnant women living with HIV whose children were born between January 2020 and December 2022. We collected prospective data on the characteristics of mothers and children using an online questionnaire (REDCap web application). RESULTS: The study included 414 mother-child dyads. Most mothers were immigrants (227/349; 65.1%). The main route of HIV infection was heterosexual transmission (160/402; 39.8%), followed by vertical transmission (44/402; 10.9%). The diagnosis was made before conception in 313/389 women (80.4%), 394/402 (98%) received ART during pregnancy and 356/402 (89.3%) had an undetectable viral load at the time of delivery. The delivery was vaginal in 230/388 children (59.3%). The proportion of preterm birth was 11.1%. The most frequent neonatal prophylaxis approach was monotherapy with zidovudine (358/414; 86.5%). There were 3 cases of vertical transmission of HIV (95% CI, 0%-1.54%). Only one newborn was breastfed. CONCLUSIONS: At present, most women living with HIV in Spain receive the diagnosis before conception, are of foreign ancestry and achieve good control of the infection. Although the VTR is very low in Spain, there are still infections that could be prevented with early diagnosis and treatment.

[Methodology and fieldwork logistics of a multilevel research study on the influence of neigbourdhood's characteristics on natives and Ecuadorian's mental health in Spain]. / Metodología y logística de campo de un estudio multinivel sobre la influencia en España de las características medioambientales en la salud mental de población autóctona y ecuatoriana inmigrante.

The methodological design, characteristics and fieldwork stage of a multilevel research study on the impact of the environmental characteristics on mental health in an autochthonous and immigrant population are described in this paper. Individual data were obtained using a core questionnaire 40 minutes length from home interviews of Spanish and Ecuadorian adults from September 2006 to January 2007. A random sample of 1186 people aged 18-55, with equal distribution of gender and nationality was obtained from Civil Registers of 33 areas (municipalities or neighbourhoods) of Madrid, Alicante, Almeria and Murcia, chosen by ethnic density and socioeconomic criteria. Previously, a pilot study was carried out. Socioeconomic indicators of neighbourhoods and selected communities were obtained from Municipal Registers and other secondary sources. Finally, 1144 people were interviewed (96%). Each person was contacted at home at two different times. The global response rate was 61%, higher among Ecuadorians (69%), who presented more problems of localisation (34%). Analyzing methods and fieldwork process the conclusion is that sample strategies for this type of population studies should be evaluated using feasibility criteria given time and money constraints, against the need to obtain representative samples of the target populations. There were serious shortcomings in the availability of social integration indicators at the neighbourhood level.

Metodología y logística de campo de un estudio multinivel sobre la influencia en España de las características medioambientales en la salud mental de población autóctona y ecuatoriana inmigrante / Methodology and fieldwork logistics of a multilevel research study on the influence of neigbourdhood’s characteristics on natives and ecuadorian’s mental health in Spain

Se realizó una investigación multinivel sobre el impacto de lascaracterísticas ambientales de la zona de residencia en la salud mentalde población autóctona e inmigrante. El objetivo de este artículo esdescribir el planteamiento metodológico de la investigación, el trabajode campo, las tasas de respuesta correspondientes y discutir el diseñometodológico y las dificultades derivadas de su puesta en práctica.Los datos individuales se obtuvieron aplicando un cuestionarioestructurado de aproximadamente 40 minutos, mediante entrevistadomiciliaria a personas españolas y ecuatorianas de 18 a 55 años. Eltrabajo se realizó de septiembre de 2006 a enero de 2007 en una muestraestimada de 1.186 personas equiparada por sexo y nacionalidad,obtenida aleatoriamente de los Padrones Municipales de 33 áreas(municipios o barrios) de Madrid, Alicante, Almería y Murcia, seleccionadassegún criterios de densidad étnica y socioeconómicos. Previamentese realizó un estudio piloto (n=113)Los indicadores sociodemográficosde las áreas se obtuvieron a partir de fuentes secundarias. Seentrevistó a 1.144 personas (96%). La tasa de respuesta global fue del61%, superior entre ecuatorianos (69%), colectivo que presentó másproblemas de localización (34%). Las negativas a colaborar fueron másaltas entre españoles (21%).Se concluye que en este tipo de estudios sería conveniente revisarlas estrategias de muestreo para combinar criterios de eficiencia con lanecesidad de obtener una muestra representativa de la población diana.Se constata la dificultad de obtener datos inframunicipales de integraciónsocial(AU)

The methodological design, characteristics and fieldwork stage ofa multilevel research study on the impact of the environmentalcharacteristics on mental health in an autochthonous and immigrantpopulation are described in this paper.Individual data were obtained using a core questionnaire 40minutes length from home interviews of Spanish and Ecuadorianadults from September 2006 to January 2007. A random sample of1186 people aged 18-55, with equal distribution of gender andnationality was obtained from Civil Registers of 33 areas(municipalities or neighbourhoods) of Madrid, Alicante, Almeria andMurcia, chosen by ethnic density and socioeconomic criteria.Previously, a pilot study was carried out. Socioeconomic indicators ofneighbourhoods and selected communities were obtained fromMunicipal Registers and other secondary sources.Finally, 1144 people were interviewed (96%). Each person wascontacted at home at two different times. The global response rate was61%, higher among Ecuadorians (69%), who presented more problemsof localisation (34%).Analyzing methods and fieldwork process the conclusion is thatsample strategies for this type of population studies should beevaluated using feasibility criteria given time and money constraints,against the need to obtain representative samples of the targetpopulations. There were serious shortcomings in the availability ofsocial integration indicators at the neighbourhood level(AU)