Detalles de la búsqueda
1.
HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats.
Neurochem Res;
48(3): 839-845, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36350432
2.
Synthesis, computational simulations and biological evaluation of new dual 5HT1A/5HT7 receptor ligands based on purine-2,6-dione scaffold.
Bioorg Chem;
139: 106737, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37482048
3.
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α1-Adrenoceptors Antagonists.
Int J Mol Sci;
24(23)2023 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38068933
4.
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A2A and Dual A1/A2A Receptor Affinity.
Int J Mol Sci;
24(18)2023 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37762006
5.
The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.
Behav Pharmacol;
33(5): 333-341, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35695543
6.
An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential.
Bioorg Chem;
121: 105695, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35228010
7.
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
Int J Mol Sci;
23(19)2022 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36232749
8.
The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
Int J Mol Sci;
22(19)2021 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34639113
9.
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.
Int J Mol Sci;
20(14)2019 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31336820
10.
Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.
Molecules;
24(24)2019 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31817628
11.
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT7 receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation.
Bioorg Med Chem Lett;
28(5): 878-883, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439902
12.
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.
Molecules;
23(10)2018 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30282913
13.
Synthesis and biological investigations of 3ß-aminotropane arylamide derivatives with atypical antipsychotic profile.
Med Chem Res;
27(8): 1906-1928, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30100693
14.
The impact of the halogen bonding on D2 and 5-HT1A/5-HT7 receptor activity of azinesulfonamides of 4-[(2-ethyl)piperidinyl-1-yl]phenylpiperazines with antipsychotic and antidepressant properties.
Bioorg Med Chem;
25(14): 3638-3648, 2017 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28529043
15.
Novel 5-HT7R antagonists, arylsulfonamide derivatives of (aryloxy)propyl piperidines: Add-on effect to the antidepressant activity of SSRI and DRI, and pro-cognitive profile.
Bioorg Med Chem;
25(10): 2789-2799, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28391970
16.
N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.
Bioorg Med Chem;
24(2): 130-9, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26706111
17.
Synthesis and biological investigation of new equatorial (ß) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
Bioorg Med Chem;
24(18): 3994-4007, 2016 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27377863
18.
Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.
J Enzyme Inhib Med Chem;
31(6): 1048-62, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26406608
19.
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile.
Bioorg Med Chem;
23(1): 212-21, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25435254
20.
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease.
J Med Chem;
67(2): 1580-1610, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38190615