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1.

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.

Singh, Mandeep; Jackson, Katherine J L; Wang, Jing J; Schofield, Peter; Field, Matt A; Koppstein, David; Peters, Timothy J; Burnett, Deborah L; Rizzetto, Simone; Nevoltris, Damien; Masle-Farquhar, Etienne; Faulks, Megan L; Russell, Amanda; Gokal, Divya; Hanioka, Asami; Horikawa, Keisuke; Colella, Alexander D; Chataway, Timothy K; Blackburn, James; Mercer, Tim R; Langley, David B; Goodall, D Margaret; Jefferis, Roy; Gangadharan Komala, Muralikrishna; Kelleher, Anthony D; Suan, Dan; Rischmueller, Maureen; Christ, Daniel; Brink, Robert; Luciani, Fabio; Gordon, Tom P; Goodnow, Christopher C; Reed, Joanne H.

Cell; 180(5): 878-894.e19, 2020 03 05.

Artículo en Inglés | MEDLINE | ID: mdl-32059783

2.

Comparative sedimentation equilibrium analysis of two IgG1 glycoforms: IgGCri and IgGWid.

Abu Hammad, Khalil; Dinu, Vlad; MacCalman, Thomas E; Pattem, Jacob; Goodall, Margaret; Gillis, Richard B; Jefferis, Roy; Harding, Stephen E.

Eur Biophys J; 52(4-5): 439-443, 2023 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-37195494

3.

Development of a rapid and quantitative lateral flow assay for the simultaneous measurement of serum κ and λ immunoglobulin free light chains (FLC): inception of a new near-patient FLC screening tool.

Campbell, John P; Heaney, Jennifer L J; Shemar, Meena; Baldwin, Dene; Griffin, Ann E; Oldridge, Emma; Goodall, Margaret; Afzal, Zaheer; Plant, Tim; Cobbold, Mark; Jefferis, Roy; Jacobs, Joannes F M; Hand, Christopher; Drayson, Mark T.

Clin Chem Lab Med; 55(3): 424-434, 2017 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-27505089

4.

Skewed Fc glycosylation profiles of anti-proteinase 3 immunoglobulin G1 autoantibodies from granulomatosis with polyangiitis patients show low levels of bisection, galactosylation, and sialylation.

Wuhrer, Manfred; Stavenhagen, Kathrin; Koeleman, Carolien A M; Selman, Maurice H J; Harper, Lorraine; Jacobs, Bart C; Savage, Caroline O S; Jefferis, Roy; Deelder, André M; Morgan, Matthew.

J Proteome Res; 14(4): 1657-65, 2015 Apr 03.

Artículo en Inglés | MEDLINE | ID: mdl-25761865

5.

Glycosylation and Fc receptors.

Hayes, Jerrard M; Cosgrave, Eoin F J; Struwe, Weston B; Wormald, Mark; Davey, Gavin P; Jefferis, Roy; Rudd, Pauline M.

Curr Top Microbiol Immunol; 382: 165-99, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-25116100

6.

Isotype and glycoform selection for antibody therapeutics.

Jefferis, Roy.

Arch Biochem Biophys; 526(2): 159-66, 2012 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-22465822

7.

Enhanced Immunomodulatory Effect of Intravenous Immunoglobulin by Fc Galactosylation and Nonfucosylation.

Mimura, Yusuke; Mimura-Kimura, Yuka; Saldova, Radka; Rudd, Pauline M; Jefferis, Roy.

Front Immunol; 13: 818382, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35154135

8.

Recombinant Proteins and Monoclonal Antibodies.

Jefferis, Roy.

Adv Biochem Eng Biotechnol; 175: 281-318, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-29071407

9.

Micro-Heterogeneity of Antibody Molecules.

Mimura, Yusuke; Saldova, Radka; Mimura-Kimura, Yuka; Rudd, Pauline M; Jefferis, Roy.

Exp Suppl; 112: 1-26, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34687006

10.

Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation.

Mimura, Yusuke; Saldova, Radka; Mimura-Kimura, Yuka; Rudd, Pauline M; Jefferis, Roy.

Exp Suppl; 112: 481-517, 2021.

Artículo en Inglés | MEDLINE | ID: mdl-34687020

11.

The antibody paradigm: present and future development as a scaffold for biopharmaceutical drugs.

Jefferis, Roy.

Biotechnol Genet Eng Rev; 26: 1-42, 2010.

Artículo en Inglés | MEDLINE | ID: mdl-21415874

12.

Glycosylation of antibody therapeutics: optimisation for purpose.

Jefferis, Roy.

Methods Mol Biol; 483: 223-38, 2009.

Artículo en Inglés | MEDLINE | ID: mdl-19183902

13.

Post-translational modifications in the context of therapeutic proteins.

Walsh, Gary; Jefferis, Roy.

Nat Biotechnol; 24(10): 1241-52, 2006 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-17033665

14.

Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment.

Magdelaine-Beuzelin, Charlotte; Kaas, Quentin; Wehbi, Vanessa; Ohresser, Marc; Jefferis, Roy; Lefranc, Marie-Paule; Watier, Hervé.

Crit Rev Oncol Hematol; 64(3): 210-25, 2007 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-17624800

15.

Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry.

Mimura, Yusuke; Ashton, Peter R; Takahashi, Noriko; Harvey, David J; Jefferis, Roy.

J Immunol Methods; 326(1-2): 116-26, 2007 Sep 30.

Artículo en Inglés | MEDLINE | ID: mdl-17714731

16.

Biologics: structural heterogeneity and immunogenicity.

Jefferis, Roy.

Br J Hosp Med (Lond); 78(8): 443-447, 2017 Aug 02.

Artículo en Inglés | MEDLINE | ID: mdl-28783398

17.

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.

Avnir, Yuval; Prachanronarong, Kristina L; Zhang, Zhen; Hou, Shurong; Peterson, Eric C; Sui, Jianhua; Zayed, Hatem; Kurella, Vinodh B; McGuire, Andrew T; Stamatatos, Leonidas; Hilbert, Brendan J; Bohn, Markus-Frederik; Kowalik, Timothy F; Jensen, Jeffrey D; Finberg, Robert W; Wang, Jennifer P; Goodall, Margaret; Jefferis, Roy; Zhu, Quan; Kurt Yilmaz, Nese; Schiffer, Celia A; Marasco, Wayne A.

Cell Rep; 21(11): 3243-3255, 2017 Dec 12.

Artículo en Inglés | MEDLINE | ID: mdl-29241550

18.

Glyco-Engineering of Human IgG-Fc to Modulate Biologic Activities.

Jefferis, Roy.

Curr Pharm Biotechnol; 17(15): 1333-1347, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-27804853

19.

Posttranslational Modifications and the Immunogenicity of Biotherapeutics.

Jefferis, Roy.

J Immunol Res; 2016: 5358272, 2016.

Artículo en Inglés | MEDLINE | ID: mdl-27191002

20.

Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.

Mimura, Yusuke; Kelly, Ronan M; Unwin, Louise; Albrecht, Simone; Jefferis, Roy; Goodall, Margaret; Mizukami, Yoichi; Mimura-Kimura, Yuka; Matsumoto, Tsuneo; Ueoka, Hiroshi; Rudd, Pauline M.

J Immunol Methods; 428: 30-6, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26627984

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Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.

Comparative sedimentation equilibrium analysis of two IgG1 glycoforms: IgGCri and IgGWid.

Development of a rapid and quantitative lateral flow assay for the simultaneous measurement of serum κ and λ immunoglobulin free light chains (FLC): inception of a new near-patient FLC screening tool.

Skewed Fc glycosylation profiles of anti-proteinase 3 immunoglobulin G1 autoantibodies from granulomatosis with polyangiitis patients show low levels of bisection, galactosylation, and sialylation.

Glycosylation and Fc receptors.

Isotype and glycoform selection for antibody therapeutics.

Enhanced Immunomodulatory Effect of Intravenous Immunoglobulin by Fc Galactosylation and Nonfucosylation.

Recombinant Proteins and Monoclonal Antibodies.

Micro-Heterogeneity of Antibody Molecules.

Importance and Monitoring of Therapeutic Immunoglobulin G Glycosylation.

The antibody paradigm: present and future development as a scaffold for biopharmaceutical drugs.

Glycosylation of antibody therapeutics: optimisation for purpose.

Post-translational modifications in the context of therapeutic proteins.

Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment.

Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry.

Biologics: structural heterogeneity and immunogenicity.

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.

Glyco-Engineering of Human IgG-Fc to Modulate Biologic Activities.

Posttranslational Modifications and the Immunogenicity of Biotherapeutics.

Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.