Detalles de la búsqueda
1.
Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration.
Bioorg Med Chem;
96: 117531, 2023 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37972434
2.
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions.
Bioorg Med Chem;
96: 117535, 2023 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37956505
3.
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.
Bioorg Chem;
134: 106465, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36933339
4.
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Molecules;
28(1)2022 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615354
5.
Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries.
Bioorg Chem;
115: 105254, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34426152
6.
Identification of novel 1,2,3-triazole isatin derivatives as potent SARS-CoV-2 3CLpro inhibitors via click-chemistry-based rapid screening.
RSC Med Chem;
14(10): 2068-2078, 2023 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37859715
7.
Development of Novel Dihydrofuro[3,4-d]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C.
J Med Chem;
65(3): 2458-2470, 2022 02 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35061384
8.
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.
J Med Chem;
65(23): 15608-15626, 2022 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36411036
9.
Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
J Med Chem;
65(24): 16902-16917, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36475694
10.
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
J Med Chem;
65(19): 13343-13364, 2022 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36107752
11.
Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.
Eur J Med Chem;
211: 113063, 2021 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33340914
12.
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.
J Med Chem;
64(7): 4239-4256, 2021 04 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33734714
13.
Fsp3: A new parameter for drug-likeness.
Drug Discov Today;
25(10): 1839-1845, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32712310
14.
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.
Eur J Med Chem;
193: 112237, 2020 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32200201
15.
Recent applications of click chemistry in drug discovery.
Expert Opin Drug Discov;
14(8): 779-789, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31094231
16.
Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors.
Drug Discov Today;
24(2): 629-635, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30503804
17.
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Eur J Med Chem;
183: 111696, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31541869
18.
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.
Chem Biol Drug Des;
93(4): 430-437, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30381875
19.
Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.
RSC Adv;
9(50): 28961-28986, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32089839
20.
Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
Eur J Med Chem;
158: 478-492, 2018 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30243152